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Published in: neurogenetics 4/2003

01-08-2003 | Letter to the Editor

Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosis

Authors: Ammar Al-Chalabi, Valerie K. Hansen, Claire L. Simpson, Jing Xi, Betsy A. Hosler, John F. Powell, Diane McKenna-Yasek, Christopher E. Shaw, P. Nigel Leigh, Robert H. Brown Jr

Published in: Neurogenetics | Issue 4/2003

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Excerpt

Sir …
Literature
1.
go back to reference Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX, et al (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis (published erratum appears in Nature 1993 364:362). Nature 362:59–62PubMed Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX, et al (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis (published erratum appears in Nature 1993 364:362). Nature 362:59–62PubMed
2.
go back to reference Suthers G, Laing N, Wilton S, Dorosz S, Waddy H (1994) "Sporadic" motoneuron disease due to familial SOD1 mutation with low penetrance. Lancet 344:1773–1773PubMed Suthers G, Laing N, Wilton S, Dorosz S, Waddy H (1994) "Sporadic" motoneuron disease due to familial SOD1 mutation with low penetrance. Lancet 344:1773–1773PubMed
3.
go back to reference Jackson M, Al-Chalabi A, Enayat ZE, Chioza B, Leigh PN, Morrison KE (1997) Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation. Ann Neurol 42:803–807PubMed Jackson M, Al-Chalabi A, Enayat ZE, Chioza B, Leigh PN, Morrison KE (1997) Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation. Ann Neurol 42:803–807PubMed
4.
go back to reference Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH, Jr., Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (2001) A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet 29:166–173CrossRefPubMed Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH, Jr., Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (2001) A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet 29:166–173CrossRefPubMed
5.
go back to reference Yang Y, Hentati A, Deng HX, Dabbagh O, Sasaki T, Hirano M, Hung WY, Ouahchi K, Yan J, Azim AC, Cole N, Gascon G, Yagmour A, Ben Hamida M, Pericak-Vance M, Hentati F, Siddique T (2001) The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet 29:160–165CrossRefPubMed Yang Y, Hentati A, Deng HX, Dabbagh O, Sasaki T, Hirano M, Hung WY, Ouahchi K, Yan J, Azim AC, Cole N, Gascon G, Yagmour A, Ben Hamida M, Pericak-Vance M, Hentati F, Siddique T (2001) The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet 29:160–165CrossRefPubMed
6.
go back to reference Barcellos LF, Klitz W, Field LL, Tobias R, Bowcock AM, Wilson R, Nelson MP, Nagatomi J, Thomson G (1997) Association mapping of disease loci, by use of a pooled DNA genomic screen. Am J Hum Genet 61:734–747PubMed Barcellos LF, Klitz W, Field LL, Tobias R, Bowcock AM, Wilson R, Nelson MP, Nagatomi J, Thomson G (1997) Association mapping of disease loci, by use of a pooled DNA genomic screen. Am J Hum Genet 61:734–747PubMed
7.
go back to reference Xie X, Ott J (1993) Testing linkage disequilibrium between a disease gene and marker loci. Am J Hum Genet 53:1107–1107PubMed Xie X, Ott J (1993) Testing linkage disequilibrium between a disease gene and marker loci. Am J Hum Genet 53:1107–1107PubMed
8.
go back to reference Sham PC, Curtis D (1995) Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59:97–105PubMed Sham PC, Curtis D (1995) Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59:97–105PubMed
Metadata
Title
Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosis
Authors
Ammar Al-Chalabi
Valerie K. Hansen
Claire L. Simpson
Jing Xi
Betsy A. Hosler
John F. Powell
Diane McKenna-Yasek
Christopher E. Shaw
P. Nigel Leigh
Robert H. Brown Jr
Publication date
01-08-2003
Publisher
Springer-Verlag
Published in
Neurogenetics / Issue 4/2003
Print ISSN: 1364-6745
Electronic ISSN: 1364-6753
DOI
https://doi.org/10.1007/s10048-003-0152-1

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