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Journal of Artificial Organs
Published in: Journal of Artificial Organs 1/2018

01-03-2018 | Original Article

Differences in tissue oxygenation and changes in total hemoglobin signal strength in the brain, liver, and lower-limb muscle during hemodialysis

Authors: Susumu Ookawara, Kiyonori Ito, Yuichiro Ueda, Haruhisa Miyazawa, Hideyuki Hayasaka, Masaya Kofuji, Takayuki Uchida, Hiroki Ishii, Mitsutoshi Shindo, Taisuke Kitano, Akinori Aomatsu, Keiji Hirai, Yoshio Kaku, Taro Hoshino, Kaoru Tabei, Yoshiyuki Morishita

Published in: Journal of Artificial Organs | Issue 1/2018

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Abstract

Near-infrared spectroscopy has been used to measure regional saturation of oxygen (rSO2) based on the total hemoglobin (t-Hb) signal strength. To date, few studies have investigated the changes of systemic oxygenation and t-Hb signal strength during hemodialysis (HD). This study aimed to (1) monitor rSO2 and t-Hb signal strength in the brain, liver, and lower-limb muscle during HD and (2) clarify the differences in rSO2 and t-Hb signal strength in each compartment. Fifty-three patients receiving 4-h HD were included and divided into three groups according to the compartments in which tissue oxygenation was measured as follows: brain (n = 44), liver (n = 42), and lower-limb muscle (n = 40). The rSO2 and t-Hb signal strength was monitored using an INVOS 5100c (Covidien Japan, Tokyo, Japan). The rSO2 levels were significantly lower in the brain than in the liver from HD initiation to the end (HD initiation: rSO2 in the brain and liver, 46.5 ± 1.3 and 52.4 ± 1.7%, respectively, p = 0.031). Furthermore, compared to the t-Hb signal strength ratio [value at t (min) during HD/initial value before HD] in the brain during HD, there were significant increases in the liver and lower-limb muscle, respectively. In conclusion, deterioration of cerebral oxygenation was remarkable compared to the hepatic oxygenation in HD patients. Our results, which revealed significant differences among the t-Hb signal strength ratios in the brain, liver, and lower-limb muscle during HD, might reflect the non-uniform body-fluid reduction within systemic tissues induced by ultrafiltration.
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Metadata
Title
Differences in tissue oxygenation and changes in total hemoglobin signal strength in the brain, liver, and lower-limb muscle during hemodialysis
Authors
Susumu Ookawara
Kiyonori Ito
Yuichiro Ueda
Haruhisa Miyazawa
Hideyuki Hayasaka
Masaya Kofuji
Takayuki Uchida
Hiroki Ishii
Mitsutoshi Shindo
Taisuke Kitano
Akinori Aomatsu
Keiji Hirai
Yoshio Kaku
Taro Hoshino
Kaoru Tabei
Yoshiyuki Morishita
Publication date
01-03-2018
Publisher
Springer Japan
Published in
Journal of Artificial Organs / Issue 1/2018
Print ISSN: 1434-7229
Electronic ISSN: 1619-0904
DOI
https://doi.org/10.1007/s10047-017-0978-1

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