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01-12-2016 | Original Article

Reversible decline in pulmonary function during left ventricular assist device therapy

Authors: Teruhiko Imamura, Koichiro Kinugawa, Osamu Kinoshita, Kan Nawata, Minoru Ono

Published in: Journal of Artificial Organs | Issue 4/2016

Abstract

Cardiac replacement therapy, consisting of left ventricular assist device (LVAD) implant surgery and heart transplantation, has considerably reduced the mortality and morbidity of patients with stage D heart failure. However, its impact on pulmonary function remains unclear. We retrospectively evaluated 22 consecutive patients (16 men; 42 ± 13 years old) who had undergone pulmonary function tests during the heart failure, LVAD, and heart transplantation periods. The LVAD therapy lasted an average of 871 ± 267 days. The % vital capacity and forced expiratory volume in 1 s decreased significantly after LVAD implantation and returned to baseline levels after heart transplantation. Correlation analysis indicated that a shorter duration of LVAD support was associated with a more significant improvement in % vital capacity in heart transplantation recipients, compared to the pre-LVAD period and the LVAD period. In conclusion, we provide evidence that a decrease in pulmonary function occurs during LVAD support but it may be reversible. Limited LVAD duration may be a key for the recovery of pulmonary dysfunction.

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Title: Reversible decline in pulmonary function during left ventricular assist device therapy
Authors: Teruhiko Imamura
Koichiro Kinugawa
Osamu Kinoshita
Kan Nawata
Minoru Ono
Publication date: 01-12-2016
Publisher: Springer Japan
Published in: Journal of Artificial Organs / Issue 4/2016
Print ISSN: 1434-7229
Electronic ISSN: 1619-0904
DOI: https://doi.org/10.1007/s10047-016-0907-8

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Reversible decline in pulmonary function during left ventricular assist device therapy

Abstract

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Abstract

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Acknowledgment to reviewers

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