Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Hernia
Published in: Hernia 6/2016

01-12-2016 | Original Article

Experimental study of inflammatory response and collagen morphometry with different types of meshes

Authors: C. T. Maeda, R. Artigani Neto, G. J. Lopes-Filho, M. M. Linhares

Published in: Hernia | Issue 6/2016

Login to get access

Abstract

Purpose

To compare an inflammation score and collagen morphometry after incisional hernia repair with four different meshes at two time points.

Methods

Four types of mesh were used to repair an abdominal wall incisional defect in Wistar rats: high-density polypropylene (HW/PP); low-density polypropylene (LW/PP); polypropylene mesh encapsulated with polydioxanone coated with oxidized cellulose (PP/CE); and expanded polytetrafluoroethylene (ePTFE). An inflammation score based on histological analysis and collagen morphometry was performed after 7 and 28 days after operation (POD).

Results

Compared to LW/PP group at 7 POD, HW/PP group had lower (p = 0.014) and PP/CE group had higher inflammation scores (p = 0.001). At 28 POD, higher scores were seen in all the other groups compared to the LW/PP group (HW/PP, p = 0.046; PP/CE, p < 0.001; ePTFE, p = 0.027). Comparing groups individually at 7 and 28 PODs, all demonstrated lower inflammation score values at 28 POD (HW/PP, p < 0.001; LW/PP, p < 0.001; PP/CE, p = 0.002; ePTFE, p = 0.001). At 7 POD, higher amounts of collagen were detected in ePTFE compared to HW/PP (p < 0.001) and LW/PP (p = 0.004) and in PPCE group compared to HW/PP (p = 0.022). At 28 POD, no statistically significant difference was found. Comparing groups individually at 7 and 28 PODs, HW/PP and LW/PP showed larger amounts of collagen at the 28th POD, without any statistically significant differences for the PP/CE and ePTFE groups.

Conclusions

Inflammation scores decreased in all groups at 28 POD. Collagen deposition was higher for non-composite meshes at 28 POD.
Literature
1.
Williams KB, Belyansky I, Dacey KT, Yurko Y, Augenstein VA, Lincourt AE, Horton J, Kercher KW, Heniford BT (2014) Impact of the establishment of a specialty hernia referral center. Surg Innov 21(6):572–579CrossRefPubMed
2.
DuBay DA, Wang X, Adamson B, Kuzon WM, Dennis RG, Franz MG (2006) Mesh incisional herniorrhaphy increases abdominal wall elastic properties: a mechanism for decreased hernia recurrences in comparison with suture repair. Surgery 140(1):14–24CrossRefPubMed
3.
Akinci M, Yilmaz KB, Kulah B, Seker GE, Ugurlu C, Kulacoglu H (2013) Association of ventral incisional hernias with comorbid diseases. Chirurgia 108(6):807–811PubMed
4.
Calvi ENC, Nahas FX, Barbosa MV, Calil JA, Ihara SSM, Juliano Y, Ferreira LM (2014) Collagen fibers in the rectus abdominis muscle of cadavers of different age. Hernia 18(4):527–533CrossRefPubMed
5.
6.
Burger JWA, Luijendijk RW, Hop WCJ, Halm JA, Verdaasdonk EGG, Jeekel J (2004) Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia. Ann Surg 240(4):578–583 (discussion 583–585) PubMedPubMedCentral
7.
Goldenberg A, Matone J, Marcondes W, Herbella FAM, Farah JFM (2005) Comparative study of inflammatory response and adhesions formation after fixation of different meshes for inguinal hernia repair in rabbits. Acta Cir Bras 20(5):347–352CrossRefPubMed
8.
Pascual G, Rodríguez M, Sotomayor S, Pérez-Köhler B, Bellón JM (2012) Inflammatory reaction and neotissue maturation in the early host tissue incorporation of polypropylene prostheses. Hernia 16(6):697–707CrossRefPubMed
9.
Klinge U, Klosterhalfen B (2012) Modified classification of surgical meshes for hernia repair based on the analyses of 1,000 explanted meshes. Hernia 16(3):251–258CrossRefPubMedPubMedCentral
10.
Klosterhalfen B, Junge K, Klinge U (2005) The lightweight and large porous mesh concept for hernia repair. Expert Rev Med Devices 2(1):103–117CrossRefPubMed
11.
Klinge U, Klosterhalfen B, Birkenhauer V, Junge K, Conze J, Schumpelick V (2002) Impact of polymer pore size on the interface scar formation in a rat model. J Surg Res 103(2):208–214CrossRefPubMed
12.
Harrell AG, Novitsky YW, Cristiano JA, Gersin KS, Norton HJ, Kercher KW, Heniford BT (2007) Prospective histologic evaluation of intra-abdominal prosthetics four months after implantation in a rabbit model. Surg Endosc 21(7):1170–1174CrossRefPubMed
13.
Pereira-lucena CG, Artigiani Neto R, de Rezende DT, Lopes-Filho GJ, Matos D, Linhares MM (2014) Early and late postoperative inflammatory and collagen deposition responses in three different meshes: an experimental study in rats. Hernia 18(4):563–570PubMed
14.
Vaz M, Krebs RK, Trindade EN, Trindade MRM (2009) Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats. Acta Cir Bras 24(1):19–25CrossRefPubMed
15.
Zogbi L, Trindade EN, Trindade MRM (2013) Comparative study of shrinkage, inflammatory response and fibroplasia in heavyweight and lightweight meshes. Hernia 17(6):765–772CrossRefPubMed
16.
Rosch R, Junge K, Knops M, Lynen P, Klinge U, Schumpelick V (2003) Analysis of collagen-interacting proteins in patients with incisional hernias. Langenbecks Arch Surg 387(11–12):427–432PubMed
17.
de Noronha L, Chin EWK, Kimura LY, Graf R (2004) Estudo morfométrico e morfológico da cicatrização após uso do laser erbium: YAG em tecidos cutâneos de ratos. J Bras Patol Med Lab 40(1):41–48CrossRef
18.
Peeters E, De Hertogh G, Junge K, Klinge U, Miserez M (2014) Skin as marker for collagen type I/III ratio in abdominal wall fascia. Hernia 18(4):519–525CrossRefPubMed
19.
Rosch R, Junge K, Quester R, Klinge U, Klosterhalfen B, Schumpelick V (2003) Vypro II® mesh in hernia repair: impact of polyglactin on long-term incorporation in rats. Eur Surg Res 35(5):445–450CrossRefPubMed
20.
Junge K, Rosch R, Krones CJ, Klinge U, Mertens PR, Lynen P, Schumpelick V, Klosterhalfen B (2005) Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair. Hernia 9(3):212–217CrossRefPubMed
Metadata
Title
Experimental study of inflammatory response and collagen morphometry with different types of meshes
Authors
C. T. Maeda
R. Artigani Neto
G. J. Lopes-Filho
M. M. Linhares
Publication date
01-12-2016
Publisher
Springer Paris
Published in
Hernia / Issue 6/2016
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-016-1513-7

Other articles of this Issue 6/2016

Hernia 6/2016 Go to the issue

Original Article

The economic burden of incisional ventral hernia repair: a multicentric cost analysis

Original Article

Isometric abdominal wall muscle strength assessment in individuals with incisional hernia: a prospective reliability study

Case Report

Inguino-scrotal herniation of the ureter containing stones

Review

Adrenal ectopy of adult groin region: a systematic review of an unexpected anatomopathologic diagnosis

Letter to the Editor

Pathological changes in herniated organs: squamous metaplasia in an inguino-scrotal bladder hernia

Original Article

Repair of recurrent hernia is often performed at a different clinic