Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Hernia
Published in: Hernia 2/2012

Open Access 01-04-2012 | Original Article

Three-year results from a preclinical implantation study of a long-term resorbable surgical mesh with time-dependent mechanical characteristics

Authors: H. Hjort, T. Mathisen, A. Alves, G. Clermont, J. P. Boutrand

Published in: Hernia | Issue 2/2012

Login to get access

Abstract

Purpose

The purpose of this study was to evaluate the biocompatibility, local tissue effects and performance of a synthetic long-term resorbable test mesh (TIGR® Matrix Surgical Mesh) compared to a non-resorbable polypropylene control mesh following implantation in a sheep model.

Methods

Full-thickness abdominal wall defects were created in 14 sheep and subsequently repaired using test or control meshes. Sacrifices were made at 4, 9, 15, 24 and 36 months and results in terms of macroscopic observations, histology and collagen analysis are described for 4, 9, 15, 24 and 36 months.

Results

The overall biocompatibility was good, and equivalent in the test and control meshes while the resorbable mesh was characterized by a collagen deposition more similar to native connective tissue and an increased thickness of the integrating tissue. The control polypropylene mesh provoked a typical chronic inflammation persistent over the 36-month study period. As the resorbable test mesh gradually degraded it was replaced by a newly formed collagen matrix with an increasing ratio of collagen type I/III, indicating a continuous remodeling of the collagen towards a strong connective tissue. After 36 months, the test mesh was fully resorbed and only microscopic implant residues could be found in the tissue.

Conclusions

This study suggests that the concept of a long-term resorbable mesh with time-dependent mechanical characteristics offers new possibilities for soft tissue repair and reinforcement.
Literature
1.
Wolstenholme JT (1956) Use of commercial dacron fabric in the repair of inguinal hernias and abdominal wall defects. AMA Arch Surg 73:1004–1008PubMedCrossRef
2.
Usher FC, Ochsner J, Tuttle LL Jr (1958) Use of marlex mesh in the repair of incisional hernias. Am Surg 24:969–974PubMed
3.
Lichtenstein IL, Shulman AG, Amid PK, Montllor MM (1989) The tension-free hernioplasty. Am J Surg 157:188–193PubMedCrossRef
4.
Klinge U, Klosterhalfen B, Müller M, Schumpelick V (1999) Foreign body reactions to meshes used for the repair of abdominal wall hernias. Eur J Surg 165:665–673PubMedCrossRef
5.
Szpaderska AM, DiPietro LA (2005) Inflammation in surgical wound healing: friend or foe? Surgery 137:571–573PubMedCrossRef
6.
O’Dwyer PJ, Kingsnorth AN, Molloy RG, et al. (2005) Randomized clinical trial assessing impact of a lightweight or heavyweight mesh on chronic pain after inguinal hernia repair. Br J Surg 92:166–170
7.
Post S, Weiss B, Willer M et al (2004) Randomized clinical trial of lightweight composite mesh for Lichtenstein inguinal hernia repair. Br J Surg 91:44–48PubMedCrossRef
8.
Smietański M, Bury K, Smietańska IA et al. (2011) Five-year results of a randomized controlled multi-centre study comparing heavy-weight knitted versus low-weight, non-woven polypropylene implants in Lichtenstein hernioplasty. Hernia. doi:10.​1007/​s10029-011-0808-y
9.
Blatnik J, Jin J, Rosen M (2008) Abdominal hernia repair with bridging acellular dermal matrix—an expensive hernia sac. Am J Surg 196:47–50PubMedCrossRef
10.
Lange DA, Zaret P, Merlotti GJ, Robin AP, Sheaff C, Barrett JA (1988) The use of absorbable mesh in splenic trauma. J Trauma 28:269–275PubMedCrossRef
11.
Delany HM, Rudavsky AZ, Lan S (1985) Preliminary clinical experience with the use of absorbable mesh splenorrhaphy. J Trauma 25:909–913PubMedCrossRef
12.
Jernigan TW, Fabian TC, Croce MA et al (2003) Staged management of giant abdominal wall defects. Ann Surg 238:349–357PubMed
13.
Efthimiou M, Symeonidis D, Koukoulis G et al (2011) Open inguinal hernia repair with the use of a polyglycolic acid-trimethylene carbonate absorbable mesh: a pilot study. Hernia 15:181–184PubMedCrossRef
14.
de Tayrac R, Chentouf S, Garreau H et al (2008) In vitro degradation and in vivo biocompatibility of poly(lactic acid) mesh for soft tissue reinforcement in vaginal surgery. J Biomed Mater Res B Appl Biomater 85:529–536PubMed
15.
de Tayrac R, Letouzey V, Garreau H et al (2010) Tissue healing during degradation of a long-lasting bioresorbable gamma-ray-sterilised poly(lactic acid) mesh in the rat: a 12-month study. Eur Surg Res 44:102–110PubMedCrossRef
16.
Klinge U, Schupelick V, Klosterhalfen B (2001) Functional assessment and tissue response of short- and long-term absorbable surgical meshes. Biomaterials 22:1415–1424PubMedCrossRef
17.
Rubert JW, Hallab NJ (2005) Strain-controlled enzymatic cleavage of collagen in loaded matrix. Biochem Biophys Res Commun 336:483–489CrossRef
18.
Junquiera LC, Cossermelli W, Brentani R (1978) Differential staining of collagens type I, II and III by Sirius red and polarization microscopy. Arch Histol Jpn 41:267–274CrossRef
19.
Poirier J, Ribadeau-Dumas J-L, Catala M, André J-M (1999) Histologie Moléculaire: Texte et Atlas. 1st edn. Masson, Paris
20.
Middleton JC, Tipton AJ (2000) Synthetic biodegradable polymers as orthopedic devices. Biomaterials 21:2335–2346PubMedCrossRef
21.
Bailey AJ, Sims TJ, Le Lous M, Bazin S (1975) Collagen polymorphism in experimental granulation tissue. Biochem Biophys Res Commun 66:1160–1165PubMedCrossRef
22.
Thermann H, Frerichs O, Holch M, Biewener A (2002) Healing of achilles tendon, an experimental study: part 2–histological, immunohistological and ultrasonographic analysis. Foot Ankle Int 23:606–613PubMed
23.
Katou F, Ohtani H, Nagura H, Motegi K (1998) Procollagen-positive fibroblasts predominantly express fibrogenic growth factors and their receptors in human encapsulation process against foreign body. J Pathol 186:201–208PubMedCrossRef
24.
Chiquet M, Gelman L, Lutz R, Maier S (2009) From mechanotransduction to extracellular matrix gene expression in fibroblasts. Biochim Biophys Acta 1793:911–920PubMedCrossRef
Metadata
Title
Three-year results from a preclinical implantation study of a long-term resorbable surgical mesh with time-dependent mechanical characteristics
Authors
H. Hjort
T. Mathisen
A. Alves
G. Clermont
J. P. Boutrand
Publication date
01-04-2012
Publisher
Springer-Verlag
Published in
Hernia / Issue 2/2012
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-011-0885-y

Other articles of this Issue 2/2012

Hernia 2/2012 Go to the issue

Original Article

Prosthetic repair of umbilical hernias in adults with local anesthesia in a day-case setting: a comprehensive report from a specialized hernia center

Case Report

Mesh erosion following laparoscopic incisional hernia repair

Original Article

Epidemiology and cost of ventral hernia repair: making the case for hernia research

Case Report

Mesenteric appendicitis strangulating small bowel: an exceptional internal herniation

Original Article

Incidence of diaphragmatic hernias following minimally invasive versus open transthoracic Ivor Lewis McKeown esophagectomy

Case Report

Open sutureless lumbar hernia repair using a ‘memory ring’ patch