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Published in: Hernia 6/2009

01-12-2009 | Original Article

Infections associated with prosthetic repairs of abdominal wall hernias: pathology, management and results

Authors: M. J. Tolino, D. E. Tripoloni, R. Ratto, M. I. García

Published in: Hernia | Issue 6/2009

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Abstract

Purpose

To analyse clinical and demographic factors of patients who suffered infection of the surgical site requiring mesh removal as a complication of prosthetic repairs, details of the hernioplasties in which meshes were implanted and their management and outcomes.

Methods

Factors related to infection (demographic variables and characteristics of the repairs and mesh utilised) and the management before proceeding to mesh removal were obtained from patient charts. Collected specimens (meshes and tissues) from 32 consecutive patients were cultured and observed microscopically. The outcomes after mesh removal were prospectively evaluated.

Results

Twenty-two patients underwent incisional hernioplasties and ten inguinal hernioplasties; most of the procedures took a long time, and 28 patients presented early wound complications (seroma or haematoma). During the “implantation–removal” interval, some conservative treatments, such as drainages or sinus resection, were attempted under local anaesthesia. Twenty-two meshes were totally removed (nine after partial extraction); in the remaining ten cases partially removal was successful. Most of the meshes (24) were made of multifilament polypropylene; microscopic observation of neighbouring tissues showed leucocyte infiltration, giant cell reaction, disorganisation of the collagen fibres and abscedation. Treatment of 32 patients required 51 operations. Following mesh removal, there were six recurrences and two fistulas of the bowel. The average follow-up was 40 months (30–97).

Conclusions

Most of the infections requiring mesh removal were related to prolonged repair operations that presented untreated early postoperative wound complications. Partial extraction of meshes frequently leads to failures and complications. Surgical exploration should be performed under general anaesthesia to accomplish complete mesh extraction.
Literature
1.
go back to reference Burger J, Luijendijk RW, Hop W, Halm J, Verdaasdunk E, Jeekel J (2004) Long-term follow-up of a randomised control trial of suture versus mesh-repair of incisional hernia. Ann Surg 240:578–585PubMed Burger J, Luijendijk RW, Hop W, Halm J, Verdaasdunk E, Jeekel J (2004) Long-term follow-up of a randomised control trial of suture versus mesh-repair of incisional hernia. Ann Surg 240:578–585PubMed
2.
go back to reference Luijendijk RW, Hop W, Van Del Tol M et al (2000) A comparison of suture-repair with mesh-repair for incisional hernia. NEJM 343:392–398CrossRefPubMed Luijendijk RW, Hop W, Van Del Tol M et al (2000) A comparison of suture-repair with mesh-repair for incisional hernia. NEJM 343:392–398CrossRefPubMed
3.
go back to reference Falagas M, Kasiakou S (2005) Mesh-related infections after hernia repair surgery. Clin Microbiol Infect 11:3–8CrossRefPubMed Falagas M, Kasiakou S (2005) Mesh-related infections after hernia repair surgery. Clin Microbiol Infect 11:3–8CrossRefPubMed
4.
go back to reference Schachtrupp A, Klinge U, Junge K et al (2002) Individual inflammatory response of human blood monocytes to mesh biomaterials. Br J Surg 90:114–120CrossRef Schachtrupp A, Klinge U, Junge K et al (2002) Individual inflammatory response of human blood monocytes to mesh biomaterials. Br J Surg 90:114–120CrossRef
5.
go back to reference Gilbert A, Felton L (1993) Infection in inguinal hernia repair considering biomaterials and antibiotics. Surg Ginecol Obst 177:126–130 Gilbert A, Felton L (1993) Infection in inguinal hernia repair considering biomaterials and antibiotics. Surg Ginecol Obst 177:126–130
6.
go back to reference Grant A (2002) Open mesh versus non-mesh repair of groin hernia: meta-analysis of randomised trials based on individual patient data. Hernia 6:130–136CrossRefPubMed Grant A (2002) Open mesh versus non-mesh repair of groin hernia: meta-analysis of randomised trials based on individual patient data. Hernia 6:130–136CrossRefPubMed
7.
go back to reference Shulman A, Amid P, Lichtenstein I (1992) The safety of mesh repair for primary inguinal hernia: results of 3,019 operations from five diverse sources. Am Surg 58:255–257PubMed Shulman A, Amid P, Lichtenstein I (1992) The safety of mesh repair for primary inguinal hernia: results of 3,019 operations from five diverse sources. Am Surg 58:255–257PubMed
8.
go back to reference Basoglu M, Yildirgan I, Balik A et al (2004) Late complications of incisional hernias following prosthetic mesh repair. Acta Chir Belg 104:425–428PubMed Basoglu M, Yildirgan I, Balik A et al (2004) Late complications of incisional hernias following prosthetic mesh repair. Acta Chir Belg 104:425–428PubMed
9.
go back to reference Klinge U, Klosterhalfen B, Birkenhauer V, Junge K, Conze J, Schumpelick V (2002) Impact of polymer pore size on the interface scar formation in a rat model. J Sur Res 103:208–214CrossRef Klinge U, Klosterhalfen B, Birkenhauer V, Junge K, Conze J, Schumpelick V (2002) Impact of polymer pore size on the interface scar formation in a rat model. J Sur Res 103:208–214CrossRef
10.
go back to reference Klosterhalfen B, Junge K, Hermanns B, Klinge U (2002) Influence of implantation interval on the long-term biocompatibility of surgical mesh. Br J Surg 89:1043–1048CrossRefPubMed Klosterhalfen B, Junge K, Hermanns B, Klinge U (2002) Influence of implantation interval on the long-term biocompatibility of surgical mesh. Br J Surg 89:1043–1048CrossRefPubMed
11.
go back to reference Papadimitriou J, Petros P (2005) Histological studies of monofilament and multifilament propylene mesh implants demonstrate equivalent penetration of macrophages between filaments. Hernia 9:75–78CrossRefPubMed Papadimitriou J, Petros P (2005) Histological studies of monofilament and multifilament propylene mesh implants demonstrate equivalent penetration of macrophages between filaments. Hernia 9:75–78CrossRefPubMed
12.
go back to reference Avtan L, Avci C, Bulut T, Fourtanier G (1997) Mesh infections after laparoscopic inguinal hernia repair. Surg Laparosc Endosc 7:192–195CrossRefPubMed Avtan L, Avci C, Bulut T, Fourtanier G (1997) Mesh infections after laparoscopic inguinal hernia repair. Surg Laparosc Endosc 7:192–195CrossRefPubMed
13.
go back to reference Bauer J, Harris M, Kreel I (1999) Twelve-year experience with expanded polytetrafluoroethylene in the repair of abdominal wall defects. Gelernt I Mt Sin J Med 66:20–25 Bauer J, Harris M, Kreel I (1999) Twelve-year experience with expanded polytetrafluoroethylene in the repair of abdominal wall defects. Gelernt I Mt Sin J Med 66:20–25
14.
go back to reference Cobb W, Harris J, Lokey J, McGill E, Klove K (2003) Incisional herniorrhaphy with intraperitoneal composite mesh: a report of 95 cases. Am Surg 69:784–787PubMed Cobb W, Harris J, Lokey J, McGill E, Klove K (2003) Incisional herniorrhaphy with intraperitoneal composite mesh: a report of 95 cases. Am Surg 69:784–787PubMed
15.
go back to reference Heniford B, Park A, Ramshaw B, Voeller G (2003) Laparoscopic repair of ventral hernias: nine years’ experience with 850 consecutive hernias. Ann Surg 238:391–400PubMed Heniford B, Park A, Ramshaw B, Voeller G (2003) Laparoscopic repair of ventral hernias: nine years’ experience with 850 consecutive hernias. Ann Surg 238:391–400PubMed
16.
go back to reference Fawole A, Chaparala R, Ambrose N (2006) Fate of the inguinal hernia following removal of infected prosthetic mesh. Hernia 10:58–61CrossRefPubMed Fawole A, Chaparala R, Ambrose N (2006) Fate of the inguinal hernia following removal of infected prosthetic mesh. Hernia 10:58–61CrossRefPubMed
17.
go back to reference Moon V, Chaudry G, Choy C, Ferzli G (2004) Mesh infection in the era of laparoscopy. J Laparoendosc Adv Surg Tech 14:349–352 Moon V, Chaudry G, Choy C, Ferzli G (2004) Mesh infection in the era of laparoscopy. J Laparoendosc Adv Surg Tech 14:349–352
18.
go back to reference Petersen S, Henke G, Freitag M et al (2001) Deep prosthesis infection in incisional hernia repair: predictive factors and clinical outcome. Eur J Surg 167:453–457CrossRefPubMed Petersen S, Henke G, Freitag M et al (2001) Deep prosthesis infection in incisional hernia repair: predictive factors and clinical outcome. Eur J Surg 167:453–457CrossRefPubMed
19.
go back to reference Taylor E, Duffy K, Lee K et al (2004) Surgical site infection after groin hernia repair. Br J Surg 91:105–111CrossRefPubMed Taylor E, Duffy K, Lee K et al (2004) Surgical site infection after groin hernia repair. Br J Surg 91:105–111CrossRefPubMed
20.
go back to reference Department of Health, Human Services, Centers for Disease Control, Prevention, Guidelines for prevention of surgical site infection (1999) Hospital Infection Control Practices Advisory Committee. Am J Inf Control 27:250–278 Department of Health, Human Services, Centers for Disease Control, Prevention, Guidelines for prevention of surgical site infection (1999) Hospital Infection Control Practices Advisory Committee. Am J Inf Control 27:250–278
21.
go back to reference Amid P (1997) Classification of biomaterials and their related complications in abdominal wall hernia surgery. Hernia 1:15–21CrossRef Amid P (1997) Classification of biomaterials and their related complications in abdominal wall hernia surgery. Hernia 1:15–21CrossRef
23.
go back to reference Arnaud J, Eloy R, Adloff M, Grenier J (1977) Critical evaluation of prosthetic materials in repair of abdominal wall hernias. Am J Surg 133:338–345CrossRefPubMed Arnaud J, Eloy R, Adloff M, Grenier J (1977) Critical evaluation of prosthetic materials in repair of abdominal wall hernias. Am J Surg 133:338–345CrossRefPubMed
24.
go back to reference Yerdel M, Akin E, Dolalan S, Turkcapar A, Pehlivan M, Gecim I, Kuterdem E (2001) Effect of single-dose prophylactic ampicillin and sulbactam on wound infection after tension-free inguinal hernia repair with polypropylene mesh: the randomised, double-blind, prospective trial. Ann Surg 233:26–33CrossRefPubMed Yerdel M, Akin E, Dolalan S, Turkcapar A, Pehlivan M, Gecim I, Kuterdem E (2001) Effect of single-dose prophylactic ampicillin and sulbactam on wound infection after tension-free inguinal hernia repair with polypropylene mesh: the randomised, double-blind, prospective trial. Ann Surg 233:26–33CrossRefPubMed
25.
go back to reference Gilbert AI, Graham MF (1997) Infected grafts of incisional hernioplasties. Hernia 1:77–81CrossRef Gilbert AI, Graham MF (1997) Infected grafts of incisional hernioplasties. Hernia 1:77–81CrossRef
26.
go back to reference Taylor G, O′Dwyer P (1999) Chronic groin sepsis following tension-free inguinal hernioplasty. Br J Surg 86:562–565CrossRefPubMed Taylor G, O′Dwyer P (1999) Chronic groin sepsis following tension-free inguinal hernioplasty. Br J Surg 86:562–565CrossRefPubMed
27.
go back to reference Deysine M (2004) Post mesh herniorraphy infection control: are we doing all we can? Hernia 8:90–91CrossRefPubMed Deysine M (2004) Post mesh herniorraphy infection control: are we doing all we can? Hernia 8:90–91CrossRefPubMed
28.
go back to reference Perez A, Roxas M, Hilvano S (2005) A randomized, double-blind, placebo-controlled trial to determine effectiveness of antibiotic prophilaxis for tension-free mesh herniorraphy. J Am Coll Surg 200:393–397CrossRefPubMed Perez A, Roxas M, Hilvano S (2005) A randomized, double-blind, placebo-controlled trial to determine effectiveness of antibiotic prophilaxis for tension-free mesh herniorraphy. J Am Coll Surg 200:393–397CrossRefPubMed
29.
go back to reference Ríos A, Rodriguez J, Munitiz V et al (2001) Antibiotic prophylaxis in incisional hernia repair using a prosthesis. Hernia 5:148–152CrossRefPubMed Ríos A, Rodriguez J, Munitiz V et al (2001) Antibiotic prophylaxis in incisional hernia repair using a prosthesis. Hernia 5:148–152CrossRefPubMed
30.
go back to reference Mann D, Prout J, Havranek E et al (1998) Late-onset deep prosthetic infection following mesh repair on inguinal hernia. Am J Surg 76:12–14CrossRef Mann D, Prout J, Havranek E et al (1998) Late-onset deep prosthetic infection following mesh repair on inguinal hernia. Am J Surg 76:12–14CrossRef
31.
32.
go back to reference Bellón J, García-Carranza A, García-Honduvilla N et al (2004) Tissue integration and biomechanical behaviour of contaminated experimental polypropylene and expanded polytetrafluoroethylene implants. Br J Surg 91:489–494CrossRefPubMed Bellón J, García-Carranza A, García-Honduvilla N et al (2004) Tissue integration and biomechanical behaviour of contaminated experimental polypropylene and expanded polytetrafluoroethylene implants. Br J Surg 91:489–494CrossRefPubMed
33.
go back to reference Greca F, Paula J, Biodo-Simoes et al (2001) The influence of differing pore sizes on the biocompatibility of two polipropylene meshes in the repair of abdominal defect. Experimental study in dogs. Hernia 5:59–64 Greca F, Paula J, Biodo-Simoes et al (2001) The influence of differing pore sizes on the biocompatibility of two polipropylene meshes in the repair of abdominal defect. Experimental study in dogs. Hernia 5:59–64
34.
go back to reference Junge K, Rosch R, Klinge U et al (2005) Gentamicin supplementation of polyvinyldenfluoride mesh materials for infection prophilaxis. Biomaterials 26:787–793CrossRefPubMed Junge K, Rosch R, Klinge U et al (2005) Gentamicin supplementation of polyvinyldenfluoride mesh materials for infection prophilaxis. Biomaterials 26:787–793CrossRefPubMed
35.
go back to reference Conze J, Rosch R, Klinge U, Weiss C et al (2004) Polipropilene in the intraabdominal position: influence of pore size and surface area. Hernia 8:365–372CrossRefPubMed Conze J, Rosch R, Klinge U, Weiss C et al (2004) Polipropilene in the intraabdominal position: influence of pore size and surface area. Hernia 8:365–372CrossRefPubMed
36.
go back to reference Klinge U, Junge K, Spellerberg B, Piroth C, Klosterhalfen B, Schumpelick V (2002) Do multifilament alloplastic meshes increase the infection rate? Analysis of the polymeric surface, the bacteria adherence, and the in vivo consequences in a rat model. J Biomed Mater Res 63:765–771CrossRefPubMed Klinge U, Junge K, Spellerberg B, Piroth C, Klosterhalfen B, Schumpelick V (2002) Do multifilament alloplastic meshes increase the infection rate? Analysis of the polymeric surface, the bacteria adherence, and the in vivo consequences in a rat model. J Biomed Mater Res 63:765–771CrossRefPubMed
37.
go back to reference Welty G, Klinge U, Klosterhalfen B (2001) Functional impairment and complaints following incisional hernia repair with different polypropylene meshes. Hernia 5:142–147CrossRefPubMed Welty G, Klinge U, Klosterhalfen B (2001) Functional impairment and complaints following incisional hernia repair with different polypropylene meshes. Hernia 5:142–147CrossRefPubMed
38.
go back to reference Costerton J, Stewart P, Greemberg E (1999) Bacterial biofilms: a common cause of persistent infections. Science 284:1318–1322CrossRefPubMed Costerton J, Stewart P, Greemberg E (1999) Bacterial biofilms: a common cause of persistent infections. Science 284:1318–1322CrossRefPubMed
39.
go back to reference Darouiche R (2003) Antimicrobial approaches for preventing infections associated with surgical implants. Clin Infect Dis 36:1284–1289CrossRefPubMed Darouiche R (2003) Antimicrobial approaches for preventing infections associated with surgical implants. Clin Infect Dis 36:1284–1289CrossRefPubMed
Metadata
Title
Infections associated with prosthetic repairs of abdominal wall hernias: pathology, management and results
Authors
M. J. Tolino
D. E. Tripoloni
R. Ratto
M. I. García
Publication date
01-12-2009
Publisher
Springer-Verlag
Published in
Hernia / Issue 6/2009
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-009-0541-y

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