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01-10-2018 | Case Report

NRAS^Q61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called “forme fruste” of neurocutaneous melanosis

Authors: Ilaria Girolami, Luca Cima, Claudio Ghimenton, Marina Zannoni, Aldo Mombello, Giulio Riva, Vito Cirielli, Gabriele Corradi, Alberto Vogrig, Gioia Di Stefano, Luca Novelli, Marco Gessi, Albino Eccher

Published in: Brain Tumor Pathology | Issue 4/2018

Abstract

Primary melanocytic tumors of central nervous system represent rare tumors arising from melanocytes of the leptomeninges. These neoplasms include focal forms like melanocytoma and primary malignant melanoma and diffuse forms like leptomeningeal melanocytosis and primary leptomeningeal melanomatosis. The clinical diagnosis remains challenging, with clinical and radiologic features overlapping with other more common diseases. Here we present a case of a 38 years old male with primary diffuse leptomeningeal melanomatosis with presence of a NRAS^Q61K mutation without features of neurocutaneous melanosis.

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Title: NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called “forme fruste” of neurocutaneous melanosis
Authors: Ilaria Girolami
Luca Cima
Claudio Ghimenton
Marina Zannoni
Aldo Mombello
Giulio Riva
Vito Cirielli
Gabriele Corradi
Alberto Vogrig
Gioia Di Stefano
Luca Novelli
Marco Gessi
Albino Eccher
Publication date: 01-10-2018
Publisher: Springer Singapore
Published in: Brain Tumor Pathology / Issue 4/2018
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-018-0328-x

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