Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Oral and Maxillofacial Surgery
Published in: Oral and Maxillofacial Surgery 4/2020

01-12-2020 | Original Article

Bone healing at collagenated bicortically installed implants: an experimental study in rabbits

Authors: Luigi Feletto, Franco Bengazi, Joaquín Juan Urbizo Velez, Mauro Ferri, Riccardo Favero, Daniele Botticelli

Published in: Oral and Maxillofacial Surgery | Issue 4/2020

Login to get access

Abstract

Purpose

To study the healing at collagenated bicortically installed implants.

Methods

Twenty albino New Zealand rabbits were used for implant installation. Two implants with a double acid etched surface, coated with a collagen type I or left uncoated, were installed bicortically in the metaphysis and in the diaphysis of each tibia. Ten rabbits were euthanized after 2 weeks and ten after 6 weeks after installation. Ground sections were prepared for histological analyses that were performed both in the cortical layers and in the marrow regions.

Results

After 2 weeks of healing, highest amounts of new bone were found at the collagenated implants (43.2 ± 6.0%) compared to the standard implants (33.9 ± 6.1%; p = 0.022). After 6 weeks of healing, similar percentages of new bone were observed, being 51.8 ± 7.3% and 50.9 ± 9.6% (p = 0.678) for the standard and collagenated surfaces, respectively.

Conclusions

A coated surface with collagen type I promoted bone apposition in the earliest periods of healing. However, the effect vanished over time so that similar results were obtained after 6 weeks of healing.
Literature
1.
Botticelli D, Lang NP (2017) Dynamics of osseointegration in various human and animal models - a comparative analysis. Clin Oral Implants Res 28(6):742–748PubMed
2.
Abrahamsson I, Berglundh T, Linder E, Lang NP, Lindhe J (2004) Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog. Clin Oral Implants Res 15(4):381–392PubMed
3.
Rossi F, Lang NP, De Santis E, Morelli F, Favero G, Botticelli D (2014) Bone-healing pattern at the surface of titanium implants: an experimental study in the dog. Clin Oral Implants Res 25(1):124–131PubMed
4.
Wennerberg A, Albrektsson T (2009) Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Implants Res 20(Suppl 4):172–184PubMed
5.
Nagassa ME, Daw AE, Rowe WG, Carley A, Thomas DW, Moseley R (2008) Optimisation of the hydrogen peroxide pre-treatment of titanium: surface characterisation and protein adsorption. Clin Oral Implants Res 19(12):1317–1326PubMed
6.
Junker R, Dimakis A, Thoneick M, Jansen JA (2009) Effects of implant surface coatings and composition on bone integration: a systematic review. Clin Oral Implants Res 20(Suppl 4):185–206PubMed
7.
Sawase T, Wennerberg A, Hallgren C, Albrektsson T, Baba K (2000) Chemical and topographical surface analysis of five different implant abutments. Clin Oral Implants Res 11(1):44–50PubMed
8.
Tugulu S, Löwe K, Scharnweber D, Schlottig F (2010) Preparation of superhydrophilic microrough titanium implant surfaces by alkali treatment. J Mater Sci Mater Med 21(10):2751–2763PubMed
9.
Rupp F, Scheideler L, Olshanska N, de Wild M, Wieland M, Geis-Gerstorfer J (2006) Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J Biomed Mater Res A 76(2):323–334PubMed
10.
Canullo L, Genova T, Tallarico M, Gautier G, Mussano F, Botticelli D (2016) Plasma of argon affects the earliest biological response of different implant surfaces: an in vitro comparative study. J Dent Res 95(5):566–573PubMed
11.
Coelho PG, Giro G, Teixeira HS, Marin C, Witek L, Thompson VP, Tovar N, Silva NR (2012) Argon-based atmospheric pressure plasma enhances early bone response to rough titanium surfaces. J Biomed Mater Res A 100(7):1901–1906PubMed
12.
Duske K, Koban I, Kindel E, Schröder K, Nebe B, Holtfreter B, Jablonowski L, Weltmann KD, Kocher T (2012) Atmospheric plasma enhances wettability and cell spreading on dental implant metals. J Clin Periodontol 39(4):400–407PubMed
13.
Beolchini M, Lang NP, Gómez Moreno G, Iezzi G, Botticelli D, Calvo Guirado JL (2016) Bone healing at implants with different surface configurations: an experimental study in dogs. Clin Oral Implants Res 27(2):196–202PubMed
14.
Caneva M, Lang NP, Calvo Guirado JL, Spriano S, Iezzi G, Botticelli D (2015) Bone healing at bicortically installed implants with different surface configurations. An experimental study in rabbits. Clin Oral Implants Res 26(3):293–299PubMed
15.
16.
Regazzoni C, Winterhalter KH, Rohrer L (2001) Type I collagen induces expression of bone morphogenetic protein receptor type II. Biochem Biophys Res Commun 283(2):316–322CrossRef
17.
Morra M, Cassinelli C, Cascardo G, Cahalan P, Cahalan L, Fini M, Giardino R (2003) Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies. Biomaterials. 24(25):4639–4654CrossRef
18.
Morra M, Cassinelli C, Cascardo G, Mazzucco L, Borzini P, Fini M, Giavaresi G, Giardino R (2006) Collagen I-coated titanium surfaces: mesenchymal cell adhesion and in vivo evaluation in trabecular bone implants. J Biomed Mater Res A 78(3):449–458CrossRef
19.
Munisamy S, Vaidyanathan TK, Vaidyanathan J (2008) A bone-like precoating strategy for implants: collagen immobilization and mineralization on pure titanium implant surface. J Oral Implantol 34(2):67–75CrossRef
20.
Morra M, Cassinelli C, Cascardo G, Bollati D, Rodriguez Y, Baena R (2010) Multifunctional implant surfaces: surface characterization and bone response to acid-etched Ti implants surface-modified by fibrillar collagen I. J Biomed Mater Res A 94(1):271–279PubMed
21.
Morra M, Cassinelli C, Cascardo G, Bollati D, Baena RR (2011) Gene expression of markers of osteogenic differentiation of human mesenchymal cells on collagen I-modified microrough titanium surfaces. J Biomed Mater Res A 96(2):449–455PubMed
22.
Sartori M, Giavaresi G, Parrilli A, Ferrari A, Aldini NN, Morra M, Cassinelli C, Bollati D, Fini M (2015) Collagen type I coating stimulates bone regeneration and osteointegration of titanium implants in the osteopenic rat. Int Orthop 39(10):2041–2052PubMed
23.
Costa DG, Ferraz EP, Abuna RPF, de Oliveira PT, Morra M, Beloti MM, Rosa AL (2017) The effect of collagen coating on titanium with nanotopography on in vitro osteogenesis. J Biomed Mater Res A 105(10):2783–2788PubMed
24.
25.
Sverzut AT, Crippa GE, Morra M, de Oliveira PT, Beloti MM, Rosa AL (2012) Effects of type I collagen coating on titanium osseointegration: histomorphometric, cellular and molecular analyses. Biomed Mater 7(3):035007PubMed
26.
de Assis AF, Beloti MM, Crippa GE, de Oliveira PT, Morra M, Rosa AL (2009) Development of the osteoblastic phenotype in human alveolar bone-derived cells grown on a collagen type I-coated titanium surface. Clin Oral Implants Res 20(3):240–246PubMed
Metadata
Title
Bone healing at collagenated bicortically installed implants: an experimental study in rabbits
Authors
Luigi Feletto
Franco Bengazi
Joaquín Juan Urbizo Velez
Mauro Ferri
Riccardo Favero
Daniele Botticelli
Publication date
01-12-2020
Publisher
Springer Berlin Heidelberg
Published in
Oral and Maxillofacial Surgery / Issue 4/2020
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI
https://doi.org/10.1007/s10006-020-00882-3

Other articles of this Issue 4/2020

Oral and Maxillofacial Surgery 4/2020 Go to the issue

Case Report

Surgical correction of ankylosed TMJ in a child: case report

Original Article

Teratocarcinoma-derived growth factor-1 (Cripto-1) is overexpressed in epithelial odontogenic lesions displaying more aggressive behaviour

Original Article

Efficacy of preoperative antibiotics in prevention of dental implant failure: a Meta-analysis of randomized controlled trials

Case Report

Can four-dimensional computed tomography support diagnosis and treatment planning?: a case report before and after coronoidectomy

Case Report

A severe case of cheilitis granulomatosa: clinical-pathologic findings and management

Original Article

Assessment of patient-specific titanium onlay versus autogenous inlay eminoplasty technique for treatment of recurrent temporomandibular joint dislocation: a randomized clinical trial