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Oral and Maxillofacial Surgery

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01-12-2020 | Antibiotic | Original Article

Efficacy of preoperative antibiotics in prevention of dental implant failure: a Meta-analysis of randomized controlled trials

Authors: Anuj Jain, Anshul Rai, Abhinav Singh, Saumya Taneja

Published in: Oral and Maxillofacial Surgery | Issue 4/2020

Abstract

Background

Dental implants are commonly used for replacement of missing teeth. Despite the published data highlighting the high success rate of dental implants, failures do occur. Some of these failures are believed to be a result of bacterial contamination at the site of implant insertion. Various antibiotic regimens have already been suggested to prevent failure due to infection.

Objective

This meta-analysis aims to examine the efficacy of preoperative antibiotics in prevention of dental implant failure secondary to infections.

Methodology

An exhaustive search was conducted on electronic database including PubMed Medline, Google Scholar, Scopus, and Cochrane on July 15, 2019. All the randomized controlled trials (RCT) comparing preoperative antibiotics with no antibiotics/placebo in dental implants were included in the study. The primary outcome for assessment was implant failure. A random effect meta-analysis was conducted for risk ratios of dichotomous data.

Results

A total 8544 abstracts were screened following which 16 full text articles were reviewed and 5 RCTs were included in the analysis. Meta-analysis results indicated that the preoperative antibiotics resulted in statistically significantly lower number of implant failures.

Conclusion

Preoperative antibiotics effectively reduce the implant failure rate. However, it is recommended to conduct large-scale RCT to determine the efficacy of preoperative antibiotics in dental implants.

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Title: Efficacy of preoperative antibiotics in prevention of dental implant failure: a Meta-analysis of randomized controlled trials
Authors: Anuj Jain
Anshul Rai
Abhinav Singh
Saumya Taneja
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Keyword: Antibiotic
Published in: Oral and Maxillofacial Surgery / Issue 4/2020
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-020-00872-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Efficacy of preoperative antibiotics in prevention of dental implant failure: a Meta-analysis of randomized controlled trials

Abstract

Background

Objective

Methodology

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objective

Methodology

Results

Conclusion

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