Skip to main content
Top
Published in: Oral and Maxillofacial Surgery 2/2020

01-06-2020 | Parathyroidectomy | Case Report

Surgical osteoplasty and soft tissue excision as treatment for facial deformities in patients with renal osteodystrophy: three case reports

Authors: Luiz Carlos Moreira Junior, Glória Maria de França, Wagner Ranier Maciel Dantas, Adriano Rocha Germano

Published in: Oral and Maxillofacial Surgery | Issue 2/2020

Login to get access

Abstract

Background

Renal osteodystrophy (ROD) may occur in patients presenting chronic kidney disease (CKD), leading to laboratory test alterations and changes in bone turnover with extra-skeletal calcifications. Treatment involves the medical management of secondary hyperparathyroidism, potential total parathyroidectomy, and surgical interventions concerning calcifications if causing facial deformities with esthetic and functional repercussions. In this context, the aim of the present study is to describe three cases of facial deformities caused by ROD treated through cosmetic-functional surgeries.

Case presentation

All patients underwent osteoplasty and soft tissue excision for several purposes, including speech difficulties, chewing difficulties, airway obstructions, malocclusion, and facial disharmony. Most patients were male (n = 2, 66.7%) with a mean age of 30.0 years old. Patients underwent a mean hemodialysis time of 9 years, and the maximum mean parathyroid hormone (PTH) level was of 2384.5 pg/ml.

Conclusions

Long hemodialysis periods and elevated PTH levels were the probable factors for the development of facial deformities in this group of patients. The main complications associated to the surgical management of facial deformities in ROD patients are directly related to end-stage renal disease, with increased risks for hemorrhage and systemic drug accumulation.
Literature
1.
go back to reference Martin KJ, Olgaard K, Coburn JW, Coen GM, Fukagawa M, Langman C et al (2004) Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodysthrophy. Am J of Kidney Dis 43(3):558–565CrossRef Martin KJ, Olgaard K, Coburn JW, Coen GM, Fukagawa M, Langman C et al (2004) Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodysthrophy. Am J of Kidney Dis 43(3):558–565CrossRef
2.
go back to reference Coen G, Ballanti P, Bonucci E, Calabria S, Costantini S, Ferrannini M, Giustini M, Giordano R, Nicolai G, Manni M, Sardella D, Taggi F (2002) Renal osteodystrophy in predialysis and hemodialysis patients: comparison of histologic patterns and diagnostic predicitivity of intact PTH. Nephron. 91(1):103–111CrossRef Coen G, Ballanti P, Bonucci E, Calabria S, Costantini S, Ferrannini M, Giustini M, Giordano R, Nicolai G, Manni M, Sardella D, Taggi F (2002) Renal osteodystrophy in predialysis and hemodialysis patients: comparison of histologic patterns and diagnostic predicitivity of intact PTH. Nephron. 91(1):103–111CrossRef
3.
go back to reference Sherrard DJ, Hercz G, Pei Y, Maloney NA, Greenwood C, Manuel A, Saiphoo C, Fenton SS, Segre GV (1993) The spectrum of bone disease in end-stage renal failure – an envolving disorder. Kidney Int 43(2):436–442CrossRef Sherrard DJ, Hercz G, Pei Y, Maloney NA, Greenwood C, Manuel A, Saiphoo C, Fenton SS, Segre GV (1993) The spectrum of bone disease in end-stage renal failure – an envolving disorder. Kidney Int 43(2):436–442CrossRef
4.
go back to reference Moe S, Drüeke T, Goodman W, Martin K, Olgaard K, Ott S et al (2006) Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 69(11):1045–1053CrossRef Moe S, Drüeke T, Goodman W, Martin K, Olgaard K, Ott S et al (2006) Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 69(11):1045–1053CrossRef
5.
go back to reference Malluche HH, Monier-faugere MC, Wang G, Frazão JM, Charytan C, Coburn JW et al (2008) An assessment of cinacalcet HCl effects on bone histology in dialysis patients with secondary hyperparathyroidism. Clin Nephrol 69(4):269–278CrossRef Malluche HH, Monier-faugere MC, Wang G, Frazão JM, Charytan C, Coburn JW et al (2008) An assessment of cinacalcet HCl effects on bone histology in dialysis patients with secondary hyperparathyroidism. Clin Nephrol 69(4):269–278CrossRef
6.
go back to reference Andrade SG, Carvalho ACGS, Magalhães TG, Cetira-filho EL, Cavalcante RB, Nogueira RLM (2018) Expansive renal osteitis fibrosa: a case report. Oral Maxillofac Surg 22(3):323–327CrossRef Andrade SG, Carvalho ACGS, Magalhães TG, Cetira-filho EL, Cavalcante RB, Nogueira RLM (2018) Expansive renal osteitis fibrosa: a case report. Oral Maxillofac Surg 22(3):323–327CrossRef
7.
go back to reference Lopes ML, Albuquerque AF, Germano AR, Queiroz LM, Miguel MC, Silveira EJ (2015) Severe maxillofacial renal osteodystrophy in two patients with chronic kidney disease. Oral Maxillofac Surg. 19(3):321–327CrossRef Lopes ML, Albuquerque AF, Germano AR, Queiroz LM, Miguel MC, Silveira EJ (2015) Severe maxillofacial renal osteodystrophy in two patients with chronic kidney disease. Oral Maxillofac Surg. 19(3):321–327CrossRef
8.
go back to reference Adornato MC, Mayne RW (2000) Macrognathia of renal osteodystrophy in a dialysis patient. Report of a case. N Y State Dent J 66(10):30–34PubMed Adornato MC, Mayne RW (2000) Macrognathia of renal osteodystrophy in a dialysis patient. Report of a case. N Y State Dent J 66(10):30–34PubMed
9.
go back to reference Hata T, Irei I, Tanaka K, Nagatsuka H, Hosoda M (2006) Macrognathia secondary to dialysis-related renal osteodystrophy treated successfully by parathyroidectomy. Int J Oral Maxillofac Surg 35(4):378–382CrossRef Hata T, Irei I, Tanaka K, Nagatsuka H, Hosoda M (2006) Macrognathia secondary to dialysis-related renal osteodystrophy treated successfully by parathyroidectomy. Int J Oral Maxillofac Surg 35(4):378–382CrossRef
10.
go back to reference Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY, Yang CW (2013) Chronic kidney disease: global dimension and perspectives. Lancet. 382(9888):260–272CrossRef Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY, Yang CW (2013) Chronic kidney disease: global dimension and perspectives. Lancet. 382(9888):260–272CrossRef
11.
go back to reference Marinho AWGB, Penha AP, Silva MT, Galvão TF (2017) Prevalência da doença renal crônica em adultos no Brasil: revisão sistemática da literatura. Cad Saúde Colet 25(3):379–388CrossRef Marinho AWGB, Penha AP, Silva MT, Galvão TF (2017) Prevalência da doença renal crônica em adultos no Brasil: revisão sistemática da literatura. Cad Saúde Colet 25(3):379–388CrossRef
12.
go back to reference Lerman MA, Do C, Gunaratnam L, Kulkarni C, Tucker K, Woo SB (2012) Localized enlargement in end-stage renal disease: two case reports and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol 113(3):384–390CrossRef Lerman MA, Do C, Gunaratnam L, Kulkarni C, Tucker K, Woo SB (2012) Localized enlargement in end-stage renal disease: two case reports and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol 113(3):384–390CrossRef
13.
go back to reference Palla B, Burian E, Fliefel R, Otto S (2018) Systematic review of oral manifestations related to hyperparathyroidism. Clin Oral Invest 22(1):1–27CrossRef Palla B, Burian E, Fliefel R, Otto S (2018) Systematic review of oral manifestations related to hyperparathyroidism. Clin Oral Invest 22(1):1–27CrossRef
14.
go back to reference Pontes FSC, Lopes AM, Souza LL, Rezende DSM, Silva ARS, Jorge J Jr et al (2018) Oral and maxillofacial manifestations of chronic kidney disease-mineral and bone disorder: a multicenter retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol 125(1):31–43CrossRef Pontes FSC, Lopes AM, Souza LL, Rezende DSM, Silva ARS, Jorge J Jr et al (2018) Oral and maxillofacial manifestations of chronic kidney disease-mineral and bone disorder: a multicenter retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol 125(1):31–43CrossRef
15.
go back to reference Rang ST, West NL, Howard J, Cousins J (2006) Anaesthesia for chronic renal disease and renal transplantation. Eur Assoc Urol 4:246–256 Rang ST, West NL, Howard J, Cousins J (2006) Anaesthesia for chronic renal disease and renal transplantation. Eur Assoc Urol 4:246–256
16.
go back to reference Lutz J, Menke J, Sollinger D, Schinzel H, Thurmel K (2014) Haemostasis in chronic kidney disease. Nephrol Dial Transplantat 29(1):29–40CrossRef Lutz J, Menke J, Sollinger D, Schinzel H, Thurmel K (2014) Haemostasis in chronic kidney disease. Nephrol Dial Transplantat 29(1):29–40CrossRef
Metadata
Title
Surgical osteoplasty and soft tissue excision as treatment for facial deformities in patients with renal osteodystrophy: three case reports
Authors
Luiz Carlos Moreira Junior
Glória Maria de França
Wagner Ranier Maciel Dantas
Adriano Rocha Germano
Publication date
01-06-2020
Publisher
Springer Berlin Heidelberg
Published in
Oral and Maxillofacial Surgery / Issue 2/2020
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI
https://doi.org/10.1007/s10006-019-00819-5

Other articles of this Issue 2/2020

Oral and Maxillofacial Surgery 2/2020 Go to the issue