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01-09-2019 | Original Article

Dental intervention against osteoradionecrosis of the jaws in irradiated patients with head and neck malignancy: a single-arm prospective study

Authors: Yumi Muraki, Masaya Akashi, Yasuo Ejima, Takumi Hasegawa, Daisuke Miyawaki, Hirotaka Shinomiya, Mika Nishii, Naoki Otsuki, Ryohei Sasaki, Ken-ichi Nibu, Takahide Komori

Published in: Oral and Maxillofacial Surgery | Issue 3/2019

Abstract

Background

The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws.

Methods

This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT.

Results

Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT.

Conclusions

Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.

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Title: Dental intervention against osteoradionecrosis of the jaws in irradiated patients with head and neck malignancy: a single-arm prospective study
Authors: Yumi Muraki
Masaya Akashi
Yasuo Ejima
Takumi Hasegawa
Daisuke Miyawaki
Hirotaka Shinomiya
Mika Nishii
Naoki Otsuki
Ryohei Sasaki
Ken-ichi Nibu
Takahide Komori
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Published in: Oral and Maxillofacial Surgery / Issue 3/2019
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-019-00783-0

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Dental intervention against osteoradionecrosis of the jaws in irradiated patients with head and neck malignancy: a single-arm prospective study

Abstract

Background

Methods

Results

Conclusions

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Abstract

Background

Methods

Results

Conclusions

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