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Oral and Maxillofacial Surgery
Published in: Oral and Maxillofacial Surgery 3/2019

01-09-2019 | Tooth Extraction | Case Report

Usefulness of platelet-rich fibrin as a hemostatic agent after dental extractions in patients receiving anticoagulant therapy with factor Xa inhibitors: a case series

Authors: Carlos Fernando de Almeida Barros Mourão, Richard J Miron, Rafael Coutinho de Mello Machado, Shahram Ghanaati, Gutemberg Gomes Alves, Mônica Diuana Calasans-Maia

Published in: Oral and Maxillofacial Surgery | Issue 3/2019

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Abstract

Purpose

To evaluate the clinical outcomes of platelet-rich fibrin (PRF) application for hemostasis after dental extraction in patients receiving anticoagulant therapy with factor Xa inhibitors.

Methods

In total, 25 patients receiving anticoagulant therapy with rivaroxaban or apixaban who required routine dental extraction were evaluated. In all patients, PRF was used for hemostasis in addition to adapting sutures. Bleeding was subjectively assessed using a sterilize gauze pad at 24, 48, and 72 h after the procedure.

Results

All invited participants (n = 25) consented to participate. The PRF clots successfully arrested bleeding after extraction in all patients, with no complications at any time point after the procedure. Favorable soft tissue healing was observed during suture removal at 10 days after the procedure in all patients, with no signs of infection or late healing.

Conclusions

The results of this case series indicate that PRF is a promising natural hemostatic agent for the management of bleeding after dental extraction in patients receiving factor Xa inhibitor therapy. Further controlled clinical studies with larger patient samples are necessary to clarify the findings of this case series.
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Metadata
Title
Usefulness of platelet-rich fibrin as a hemostatic agent after dental extractions in patients receiving anticoagulant therapy with factor Xa inhibitors: a case series
Authors
Carlos Fernando de Almeida Barros Mourão
Richard J Miron
Rafael Coutinho de Mello Machado
Shahram Ghanaati
Gutemberg Gomes Alves
Mônica Diuana Calasans-Maia
Publication date
01-09-2019
Publisher
Springer Berlin Heidelberg
Published in
Oral and Maxillofacial Surgery / Issue 3/2019
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI
https://doi.org/10.1007/s10006-019-00769-y

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