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Oral and Maxillofacial Surgery

Published in:

01-09-2018 | Original Article

Plasma rich in growth factors (PRGF) for the promotion of bone cell proliferation and tissue regeneration

Authors: Matteo Brucoli, Roberta Sonzini, Michela Bosetti, Paolo Boffano, Arnaldo Benech

Published in: Oral and Maxillofacial Surgery | Issue 3/2018

Abstract

Objectives

Over the past few years, studies about growth factors have been increasingly developed and the knowledge of their role in stimulating cell proliferation and differentiation used for therapeutic purposes. This study aims to compare a platelets concentrate, the plasma rich in growth factors (PRGF) to a control, consisting of cellulose membranes, to evaluate in vitro the cellular adhesion and migration of human osteoblasts (hOb) and understand if the use of platelets concentrates could be an advantage in view of bone tissue regeneration.

Study design

Twenty-seven human donors provided 27 blood samples used to make 54 samples: 27 for PRGF and 27 for the control group. PRGFs and controls were incubated for 48 h in sterility in 1 ml of culture with 10⁵ hOb and hOb in the scaffolds were then quantified.

Results

In PRGF samples, hObs were more numerous than in controls. (T = 6.6964, p < 0.0001).

Conclusions

Human osteoblasts are driven to colonize PRGFs with a greater efficacy than negative controls, probably due to the presence of chemokines and growth factors in PRGFs.

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Title: Plasma rich in growth factors (PRGF) for the promotion of bone cell proliferation and tissue regeneration
Authors: Matteo Brucoli
Roberta Sonzini
Michela Bosetti
Paolo Boffano
Arnaldo Benech
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: Oral and Maxillofacial Surgery / Issue 3/2018
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-018-0712-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Plasma rich in growth factors (PRGF) for the promotion of bone cell proliferation and tissue regeneration

Abstract

Objectives

Study design

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Study design

Results

Conclusions

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