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01-03-2012 | Case Report

Diffuse swelling of the buccal mucosa and palate as first and only manifestation of an extranodal non-Hodgkin ‘double-hit’ lymphoma: report of a case

Authors: Marc Frei, Patrick Dubach, Peter A. Reichart, Anja M. Schmitt, Esther Mueller-Garamvölgyi, Michael M. Bornstein

Published in: Oral and Maxillofacial Surgery | Issue 1/2012

Abstract

Background

Most of the lymphomas arising in the oral cavity are of B-cell origin. Among these, diffuse large B-cell lymphomas are the most common. Diffuse large B-cell lymphomas may exhibit more than one chromosomal rearrangement and are then referred to as ‘double-hit’ or ‘triple-hit’ lymphomas.

Case report

We present a case of an intraoral ‘double-hit’ lymphoma in a 76-year-old male who had been referred by an oral surgeon in private practice. Intraoral examination exhibited a firm, exophytic lesion in the region of the right hard palate and buccal mucosa with extension to the soft palate. Radiographic examination exhibited a massive thickening of the right sinus membrane, and arrosion of the lateral and basal cortical sinus walls in the right maxilla. After diagnosis of the lesion, the patient was treated with six cycles of chemotherapy.

Discussion

Lymphomas arising within the oral cavity account for less than 5% of all oral malignancies and typically affect the palatine tonsils and the palate. ‘Double-hit’ lymphomas are associated with older age, usually present with an advanced stage of disease, and show an aggressive clinical behaviour. They normally have a poor prognosis, even when treated with intensive chemotherapy regimens. Nevertheless, in the case presented, the patient was free of symptoms 1 year after initial diagnosis.

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Title: Diffuse swelling of the buccal mucosa and palate as first and only manifestation of an extranodal non-Hodgkin ‘double-hit’ lymphoma: report of a case
Authors: Marc Frei
Patrick Dubach
Peter A. Reichart
Anja M. Schmitt
Esther Mueller-Garamvölgyi
Michael M. Bornstein
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Oral and Maxillofacial Surgery / Issue 1/2012
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-010-0254-5

At a glance: The STEP trials

Springer Medicine

Diffuse swelling of the buccal mucosa and palate as first and only manifestation of an extranodal non-Hodgkin ‘double-hit’ lymphoma: report of a case

Abstract

Background

Case report

Discussion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case report

Discussion

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