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Medical Molecular Morphology
Published in: Medical Molecular Morphology 1/2019

01-03-2019 | Original Paper

Physical exercise alters hepatic morphology of low-density lipoprotein receptor knockout ovariectomized mice

Authors: Franciele Mercúrio Rodrigues, Jenifer Inácio Adélio, Vanessa Oliveira Santana, Elisabeth De Marco Ornelas, Romeu Rodrigues de Souza, Clever Gomes Cardoso, Glaucia Luciano da Veiga, Fernando Luiz Affonso Fonseca, Laura Beatriz Mesiano Maifrino

Published in: Medical Molecular Morphology | Issue 1/2019

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Abstract

To explore the effects of physical exercise on the liver of animals in menopause, we analyzed the histomorphometric parameters of the hepatic tissue in ovariectomized and dyslipidemic female mice. The animals were distributed in six groups (n = 5): sedentary control (SC), sedentary ovariectomized control (SOC), trained ovariectomized control (TOC), sedentary LDL knockout (LDL-S), sedentary ovariectomized LDL knockout (LDL-SO), and trained ovariectomized LDL knockout (LDL-TO). At the end of the experiment, the liver and the visceral adipose tissue (VAT) of animals were removed for morphometric and stereological studies. In the LDL-S and LDL-SO animals, both sedentary, results showed reduction in the area (µm2) and major and minor diameters (µm) of hepatocytes and reduction in the portions of large hepatocytes, and increase in the percentage of Kupffer cells. The trained group showed a tendency of increase in the area and diameter and in the percentage of hepatocytes, as well significant reduction in the percentage of Kupffer cells and interstitial tissue. We suggested that training can prevent cell and tissue damage caused by the process of increase in hepatic fat, lipoperoxidation, and tissue inflammation in animals with privation of estrogen and dyslipidemia, apparently reflecting a better metabolic response of the hepatic tissue in organisms undergoing training.
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Metadata
Title
Physical exercise alters hepatic morphology of low-density lipoprotein receptor knockout ovariectomized mice
Authors
Franciele Mercúrio Rodrigues
Jenifer Inácio Adélio
Vanessa Oliveira Santana
Elisabeth De Marco Ornelas
Romeu Rodrigues de Souza
Clever Gomes Cardoso
Glaucia Luciano da Veiga
Fernando Luiz Affonso Fonseca
Laura Beatriz Mesiano Maifrino
Publication date
01-03-2019
Publisher
Springer Japan
Published in
Medical Molecular Morphology / Issue 1/2019
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI
https://doi.org/10.1007/s00795-018-0198-7

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