Skip to main content
Top
Published in: European Child & Adolescent Psychiatry 10/2016

01-10-2016 | Original Contribution

The association between familial ASD diagnosis, autism symptomatology and developmental functioning in young children

Authors: Jasper A. Estabillo, Johnny L. Matson, Xinrui Jiang

Published in: European Child & Adolescent Psychiatry | Issue 10/2016

Login to get access

Abstract

Few studies have directly compared individuals with and without a relative diagnosed with ASD on various domains. The present study aimed to examine the relationship between familial ASD diagnosis and the exhibition of ASD symptoms in young children with and without ASD diagnoses. Participants included 8353 children aged 17–37 months old and their families. They were divided into four groups based on individual and family diagnosis, then compared on autism symptomatology and developmental domains. No differences were found between ASD groups on overall scores and each of the factor domains, indicating no association between family ASD diagnosis and ASD symptomatology or developmental functioning. Disparate results were found for atypically developing groups with and without relatives diagnosed with ASD. Implications of these results are discussed.
Literature
1.
go back to reference Howlin P, Udwin O (2002) Outcomes in neurodevelopmental and genetic disorders. Cambridge University Press, New YorkCrossRef Howlin P, Udwin O (2002) Outcomes in neurodevelopmental and genetic disorders. Cambridge University Press, New YorkCrossRef
2.
go back to reference McPartland JC, Reichow B, Volkmar FR (2012) Sensitivity and specificity of proposed DSM-5 diagnostic criteria for autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 51:368–383CrossRefPubMedPubMedCentral McPartland JC, Reichow B, Volkmar FR (2012) Sensitivity and specificity of proposed DSM-5 diagnostic criteria for autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 51:368–383CrossRefPubMedPubMedCentral
3.
go back to reference Volkmar FR, Pelphrey K (2014) Autism and autism spectrum disorders. In: Oxf. Textb. Psychopathol. P H Blaney R F Krueger T Millon Eds, 3rd ed. Oxford University Press, New York, pp 530–539 Volkmar FR, Pelphrey K (2014) Autism and autism spectrum disorders. In: Oxf. Textb. Psychopathol. P H Blaney R F Krueger T Millon Eds, 3rd ed. Oxford University Press, New York, pp 530–539
6.
go back to reference Wang Y, Zhong N (2012) Clinical and genetic heterogeneity of autism. Mutat Hum Genet Dis Wang Y, Zhong N (2012) Clinical and genetic heterogeneity of autism. Mutat Hum Genet Dis
10.
12.
go back to reference Rutter M (2000) Genetic studies of autism: from the 1970s into the millennium. J Abnorm Child Psychol 28:3–14CrossRefPubMed Rutter M (2000) Genetic studies of autism: from the 1970s into the millennium. J Abnorm Child Psychol 28:3–14CrossRefPubMed
13.
18.
go back to reference Ozonoff S, Young GS, Carter A et al (2011) Recurrence risk for autism spectrum disorders: a baby siblings research consortium study. Pediatrics 128:e488–e495PubMedPubMedCentral Ozonoff S, Young GS, Carter A et al (2011) Recurrence risk for autism spectrum disorders: a baby siblings research consortium study. Pediatrics 128:e488–e495PubMedPubMedCentral
21.
23.
go back to reference Rutter M, Thapar A Genetics of autism spectrum disorders. In: Volmar FR, Rogers SJ, Paul R, Pelphrey KA, (Eds.). In: Handb. Autism Pervasive Dev. Disord. Vol. 1 Diagn. Dev. Brain Mech., 4th ed. John Wiley & Sons Inc., Hoboken, NJ, pp 411–423 Rutter M, Thapar A Genetics of autism spectrum disorders. In: Volmar FR, Rogers SJ, Paul R, Pelphrey KA, (Eds.). In: Handb. Autism Pervasive Dev. Disord. Vol. 1 Diagn. Dev. Brain Mech., 4th ed. John Wiley & Sons Inc., Hoboken, NJ, pp 411–423
24.
go back to reference Gerdts J, Bernier R (2011) The broader autism phenotype and its implications on the etiology and treatment of autism spectrum disorders. Autism Res Treat 2011:1–19. doi:10.1155/2011/545901 CrossRef Gerdts J, Bernier R (2011) The broader autism phenotype and its implications on the etiology and treatment of autism spectrum disorders. Autism Res Treat 2011:1–19. doi:10.​1155/​2011/​545901 CrossRef
27.
go back to reference Miller M, Young GS, Hutman T et al (2015) Early pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder? J Child Psychol Psychiatry 56:774–781. doi:10.1111/jcpp.12342 CrossRefPubMed Miller M, Young GS, Hutman T et al (2015) Early pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder? J Child Psychol Psychiatry 56:774–781. doi:10.​1111/​jcpp.​12342 CrossRefPubMed
28.
30.
go back to reference Sasson NJ, Lam KS, Parlier M et al (2013) Autism and the broad autism phenotype: familial patterns and intergenerational transmission. J Neurodev Disord 5:11CrossRefPubMedPubMedCentral Sasson NJ, Lam KS, Parlier M et al (2013) Autism and the broad autism phenotype: familial patterns and intergenerational transmission. J Neurodev Disord 5:11CrossRefPubMedPubMedCentral
31.
go back to reference Wheelwright S, Auyeung B, Allison C, Baron-Cohen S (2010) Research defining the broader, medium and narrow autism phenotype among parents using the Autism Spectrum Quotient (AQ). Mol Autism 1: Wheelwright S, Auyeung B, Allison C, Baron-Cohen S (2010) Research defining the broader, medium and narrow autism phenotype among parents using the Autism Spectrum Quotient (AQ). Mol Autism 1:
32.
go back to reference Taylor LJ, Maybery MT, Wray J et al (2013) Brief report: do the nature of communication impairments in autism spectrum disorders relate to the broader autism phenotype in parents? J Autism Dev Disord 43:2984–2989. doi:10.1007/s10803-013-1838-3 CrossRefPubMed Taylor LJ, Maybery MT, Wray J et al (2013) Brief report: do the nature of communication impairments in autism spectrum disorders relate to the broader autism phenotype in parents? J Autism Dev Disord 43:2984–2989. doi:10.​1007/​s10803-013-1838-3 CrossRefPubMed
33.
go back to reference Hasegawa C, Kikuchi M, Yoshimura Y et al (2015) Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders: broad autism phenotype in parents. Psychiatry Clin Neurosci 69:136–144. doi:10.1111/pcn.12210 CrossRefPubMed Hasegawa C, Kikuchi M, Yoshimura Y et al (2015) Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders: broad autism phenotype in parents. Psychiatry Clin Neurosci 69:136–144. doi:10.​1111/​pcn.​12210 CrossRefPubMed
34.
go back to reference Parr JR, Gray L, Wigham S et al (2015) Measuring the relationship between the parental broader autism phenotype, parent–child interaction, and children’s progress following parent mediated intervention. Res Autism Spectr Disord 20:24–30. doi:10.1016/j.rasd.2015.07.006 CrossRef Parr JR, Gray L, Wigham S et al (2015) Measuring the relationship between the parental broader autism phenotype, parent–child interaction, and children’s progress following parent mediated intervention. Res Autism Spectr Disord 20:24–30. doi:10.​1016/​j.​rasd.​2015.​07.​006 CrossRef
41.
go back to reference American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Washington, DC American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Washington, DC
42.
go back to reference Matson J, Boisjoli J, Wilkins J (2007) The baby and infant screen for children with aUtIsm traits (BISCUIT). Baton Rouge Disabil Consult, LLC Matson J, Boisjoli J, Wilkins J (2007) The baby and infant screen for children with aUtIsm traits (BISCUIT). Baton Rouge Disabil Consult, LLC
43.
go back to reference Newborg J (2005) Battelle developmental inventory, 2nd edn. Riverside, Itasca Newborg J (2005) Battelle developmental inventory, 2nd edn. Riverside, Itasca
44.
go back to reference Matson JL, Boisjoli JA, Hess JA, Wilkins J (2010) Factor structure and diagnostic fidelity of the Baby and Infant Screen for Children with aUtIsm Traits-Part 1 (BISCUIT-Part 1). Dev Neurorehabilitation 13:72–79CrossRef Matson JL, Boisjoli JA, Hess JA, Wilkins J (2010) Factor structure and diagnostic fidelity of the Baby and Infant Screen for Children with aUtIsm Traits-Part 1 (BISCUIT-Part 1). Dev Neurorehabilitation 13:72–79CrossRef
45.
go back to reference Matson JL, Wilkins J, Sevin JA et al (2009) Reliability and item content of the Baby and Infant Screen for Children with aUtIsm Traits (BISCUIT): parts 1–3. Res Autism Spectr Disord 3:336–344CrossRef Matson JL, Wilkins J, Sevin JA et al (2009) Reliability and item content of the Baby and Infant Screen for Children with aUtIsm Traits (BISCUIT): parts 1–3. Res Autism Spectr Disord 3:336–344CrossRef
46.
go back to reference Matson JL, Wilkins J, Sharp B et al (2009) Sensitivity and specificity of the Baby and Infant Screen for Children with aUtIsm Traits (BISCUIT): validity and cutoff scores for autism and PDD-NOS in toddlers. Res Autism Spectr Disord 3:924–930CrossRef Matson JL, Wilkins J, Sharp B et al (2009) Sensitivity and specificity of the Baby and Infant Screen for Children with aUtIsm Traits (BISCUIT): validity and cutoff scores for autism and PDD-NOS in toddlers. Res Autism Spectr Disord 3:924–930CrossRef
47.
go back to reference Wingate M, Kirby RS, Pettygrove S et al (2014) Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ 63:1–21 Wingate M, Kirby RS, Pettygrove S et al (2014) Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ 63:1–21
48.
go back to reference US Census Bureau (2000) Population by race and Hispanic or latino origin, for all ages and for 18 years and over, for Louisiana: 2000 US Census Bureau (2000) Population by race and Hispanic or latino origin, for all ages and for 18 years and over, for Louisiana: 2000
49.
go back to reference Field A (2013) Discovering statistics using IBM SPSS Statistics, Fourth Edition edition. SAGE Publications Ltd, Los Angeles Field A (2013) Discovering statistics using IBM SPSS Statistics, Fourth Edition edition. SAGE Publications Ltd, Los Angeles
50.
go back to reference Tabachnick BG (2012) Using multivariate statistics, 6 edition. Pearson Tabachnick BG (2012) Using multivariate statistics, 6 edition. Pearson
53.
go back to reference Johnson MH, Gliga T, Jones E, Charman T (2015) Annual research review: infant development, autism, and ADHD–early pathways to emerging disorders. J Child Psychol Psychiatry 56:228–247CrossRefPubMed Johnson MH, Gliga T, Jones E, Charman T (2015) Annual research review: infant development, autism, and ADHD–early pathways to emerging disorders. J Child Psychol Psychiatry 56:228–247CrossRefPubMed
54.
go back to reference Martin J, Cooper M, Hamshere ML, et al. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. J Am Acad Child Adolesc Psychiatry 53:761–770.e26. doi: 10.1016/j.jaac.2014.03.004 Martin J, Cooper M, Hamshere ML, et al. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. J Am Acad Child Adolesc Psychiatry 53:761–770.e26. doi: 10.​1016/​j.​jaac.​2014.​03.​004
Metadata
Title
The association between familial ASD diagnosis, autism symptomatology and developmental functioning in young children
Authors
Jasper A. Estabillo
Johnny L. Matson
Xinrui Jiang
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
European Child & Adolescent Psychiatry / Issue 10/2016
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-016-0838-1

Other articles of this Issue 10/2016

European Child & Adolescent Psychiatry 10/2016 Go to the issue