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Published in: European Child & Adolescent Psychiatry 9/2015

01-09-2015 | Original Contribution

Quality of life in children with OCD before and after treatment

Authors: Bernhard Weidle, Tord Ivarsson, Per Hove Thomsen, Stian Lydersen, Thomas Jozefiak

Published in: European Child & Adolescent Psychiatry | Issue 9/2015

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Abstract

Quality of life (QoL) is a well-established outcome measure. In contrast to adult obsessive–compulsive disorder (OCD), little is known about the effects of treatment on QoL in children with OCD. This study aimed to assess QoL after cognitive behavioural therapy (CBT) in children and adolescents with OCD compared with the general population and to explore factors associated with potential changes in QoL after treatment. QoL was assessed in 135 children and adolescents (ages 7–17; mean 13 [SD 2.7] years; 48.1 % female) before and after 14 CBT sessions, using self-report and a caregivers proxy report of the Questionnaire for Measuring Health-related Quality of Life in Children and Adolescents (KINDL-R). QoL was compared with an age- and gender-matched sample from the general population. Before treatment, QoL was markedly lower in children with OCD compared with the general population. QoL improved significantly in CBT responders (mean score change 7.4), to the same range as QoL in the general population. Non-responders reported no QoL changes after treatment, except for one patient. Comorbidity, family accommodation and psychosocial functioning were not associated with changes in QoL after treatment. To our knowledge, this is the first study of the changes in QoL after treatment of paediatric OCD. The assessment of QoL beyond symptoms and function in children with OCD has been shown to be reliable and informative. The results of this study support the application of QoL assessment as an additional measure of treatment outcome in children and adolescents with OCD.
Literature
1.
2.
3.
go back to reference Verhulst FC, van der Ende J, Ferdinand RF, Kasius MC (1997) The prevalence of DSM-III-R diagnoses in a national sample of Dutch adolescents. Arch Gen Psychiatry 54(4):329–336PubMedCrossRef Verhulst FC, van der Ende J, Ferdinand RF, Kasius MC (1997) The prevalence of DSM-III-R diagnoses in a national sample of Dutch adolescents. Arch Gen Psychiatry 54(4):329–336PubMedCrossRef
5.
go back to reference Skoog G, Skoog I (1999) A 40-year follow-up of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 56(2):121–127PubMedCrossRef Skoog G, Skoog I (1999) A 40-year follow-up of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 56(2):121–127PubMedCrossRef
7.
go back to reference Hanna GL (1995) Demographic and clinical feature of obsessive-compulsive disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry 34:19–27PubMedCrossRef Hanna GL (1995) Demographic and clinical feature of obsessive-compulsive disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry 34:19–27PubMedCrossRef
10.
go back to reference Cath DC, Ran N, Smit JH, van Balkom AJ, Comijs HC (2008) Symptom overlap between autism spectrum disorder, generalized social anxiety disorder and obsessive-compulsive disorder in adults: a preliminary case-controlled study. Psychopathology 41(2):101–110. doi:10.1159/000111555 PubMedCrossRef Cath DC, Ran N, Smit JH, van Balkom AJ, Comijs HC (2008) Symptom overlap between autism spectrum disorder, generalized social anxiety disorder and obsessive-compulsive disorder in adults: a preliminary case-controlled study. Psychopathology 41(2):101–110. doi:10.​1159/​000111555 PubMedCrossRef
11.
go back to reference LaSalle VH, Cromer KR, Nelson KN, Kazuba D, Justement L, Murphy DL (2004) Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with obsessive-compulsive disorder. Depress Anxiety 19(3):163–173. doi:10.1002/da.20009 PubMedCrossRef LaSalle VH, Cromer KR, Nelson KN, Kazuba D, Justement L, Murphy DL (2004) Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with obsessive-compulsive disorder. Depress Anxiety 19(3):163–173. doi:10.​1002/​da.​20009 PubMedCrossRef
15.
go back to reference NICE (2005) Obsessive-compulsive disorder: core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder. Clinical Guideline 31 NICE (2005) Obsessive-compulsive disorder: core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder. Clinical Guideline 31
18.
go back to reference Koot HM (2001) The study of quality of life: concepts and methods. In: Koot HM, Wallander JL (eds) Quality of Life in children and adolescent illness: Concepts, methods, and findings. Brunner-Routledge, East Essex, UK Koot HM (2001) The study of quality of life: concepts and methods. In: Koot HM, Wallander JL (eds) Quality of Life in children and adolescent illness: Concepts, methods, and findings. Brunner-Routledge, East Essex, UK
19.
go back to reference EMEA (2004) Reflection paper on the regulatory guidance for the use of health-related quality of life (HRQL) measures in the evaluation of medicinal products European Medicines Agency London EMEA (2004) Reflection paper on the regulatory guidance for the use of health-related quality of life (HRQL) measures in the evaluation of medicinal products European Medicines Agency London
20.
go back to reference FDA (2006) Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance. Health Qual Life Outcomes 4:79. doi:10.1186/1477-7525-4-79 CrossRef FDA (2006) Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance. Health Qual Life Outcomes 4:79. doi:10.​1186/​1477-7525-4-79 CrossRef
22.
go back to reference Hollander E, Stein DJ, Fineberg NA, Marteau F, Legault M (2010) Quality of life outcomes in patients with obsessive-compulsive disorder: relationship to treatment response and symptom relapse. J Clin Psychiatry 71(6):784–792. doi:10.4088/JCP.09m05911blu PubMedCrossRef Hollander E, Stein DJ, Fineberg NA, Marteau F, Legault M (2010) Quality of life outcomes in patients with obsessive-compulsive disorder: relationship to treatment response and symptom relapse. J Clin Psychiatry 71(6):784–792. doi:10.​4088/​JCP.​09m05911blu PubMedCrossRef
23.
go back to reference Koran LM (2000) Quality of life in obsessive-compulsive disorder. Psychiatr Clin North Am 23(3):509–517PubMedCrossRef Koran LM (2000) Quality of life in obsessive-compulsive disorder. Psychiatr Clin North Am 23(3):509–517PubMedCrossRef
25.
go back to reference Moritz S (2008) A review on quality of life and depression in obsessive-compulsive disorder. CNS Spectr 13(9 Suppl 14):16–22PubMedCrossRef Moritz S (2008) A review on quality of life and depression in obsessive-compulsive disorder. CNS Spectr 13(9 Suppl 14):16–22PubMedCrossRef
29.
go back to reference Hertenstein E, Thiel N, Herbst N, Freyer T, Nissen C, Kulz AK, Voderholzer U (2013) Quality of life changes following inpatient and outpatient treatment in obsessive-compulsive disorder: a study with 12 months follow-up. Ann Gen Psychiatry 12(1):4. doi:10.1186/1744-859X-12-4 PubMedCentralPubMedCrossRef Hertenstein E, Thiel N, Herbst N, Freyer T, Nissen C, Kulz AK, Voderholzer U (2013) Quality of life changes following inpatient and outpatient treatment in obsessive-compulsive disorder: a study with 12 months follow-up. Ann Gen Psychiatry 12(1):4. doi:10.​1186/​1744-859X-12-4 PubMedCentralPubMedCrossRef
32.
go back to reference Jozefiak T (2014) Can we trust in parents’ report about their childrens well-being? In: Holte A et. al. The psychology of child well-being. In: Asher Ben-Arieh FC, Ivar Frønes, Jill E. Korbin (ed) Handbook of child well-being. Theories, methods and policies in global perspective. Springer Netherlands, pp 555–631 Jozefiak T (2014) Can we trust in parents’ report about their childrens well-being? In: Holte A et. al. The psychology of child well-being. In: Asher Ben-Arieh FC, Ivar Frønes, Jill E. Korbin (ed) Handbook of child well-being. Theories, methods and policies in global perspective. Springer Netherlands, pp 555–631
35.
go back to reference Casas F in A. Holte MMB, Bekkhus M, Borge AIH, Bowes L, Casas F, Friborg O, Grinde B, Headey B, Jozefiak T, Lekhal R, Marks N, Muffels R, Nes RB, Røysamb E, Thimm J, Torgersen S, Trommsdorff G, Veenhoven R, Vittersø J, Waaktaar T, Wagner GG, Wang CE, Wold B, Zachrisson HD (2014) Psychology of child well-being In: Ben-Arieh A, Casas F, Frønes I, Korbin JE (eds) Handbook of child well-being: theories, metods and policies in global perspective. Springer, pp 555–632 Casas F in A. Holte MMB, Bekkhus M, Borge AIH, Bowes L, Casas F, Friborg O, Grinde B, Headey B, Jozefiak T, Lekhal R, Marks N, Muffels R, Nes RB, Røysamb E, Thimm J, Torgersen S, Trommsdorff G, Veenhoven R, Vittersø J, Waaktaar T, Wagner GG, Wang CE, Wold B, Zachrisson HD (2014) Psychology of child well-being In: Ben-Arieh A, Casas F, Frønes I, Korbin JE (eds) Handbook of child well-being: theories, metods and policies in global perspective. Springer, pp 555–632
36.
go back to reference Palermo SD, Bloch MH, Craiglow B, Landeros-Weisenberger A, Dombrowski PA, Panza K, Smith ME, Peterson BS, Leckman JF (2011) Predictors of early adulthood quality of life in children with obsessive-compulsive disorder. Soc Psychiatry Psychiatr Epidemiol 46(4):291–297. doi:10.1007/s00127-010-0194-2 PubMedCentralPubMedCrossRef Palermo SD, Bloch MH, Craiglow B, Landeros-Weisenberger A, Dombrowski PA, Panza K, Smith ME, Peterson BS, Leckman JF (2011) Predictors of early adulthood quality of life in children with obsessive-compulsive disorder. Soc Psychiatry Psychiatr Epidemiol 46(4):291–297. doi:10.​1007/​s00127-010-0194-2 PubMedCentralPubMedCrossRef
37.
go back to reference Lack CW, Storch EA, Keeley ML, Geffken GR, Ricketts ED, Murphy TK, Goodman WK (2009) Quality of life in children and adolescents with obsessive-compulsive disorder: base rates, parent-child agreement, and clinical correlates. Soc Psychiatry Psychiatr Epidemiol 44(11):935–942. doi:10.1007/s00127-009-0013-9 PubMedCrossRef Lack CW, Storch EA, Keeley ML, Geffken GR, Ricketts ED, Murphy TK, Goodman WK (2009) Quality of life in children and adolescents with obsessive-compulsive disorder: base rates, parent-child agreement, and clinical correlates. Soc Psychiatry Psychiatr Epidemiol 44(11):935–942. doi:10.​1007/​s00127-009-0013-9 PubMedCrossRef
39.
go back to reference Ivarsson T, Thomsen PH, Dahl K, Valderhaug R, Weidle B, Nissen JB, Englyst I, Christensen K, Torp NC, Melin K (2010) The rationale and some features of the Nordic Long-term OCD Treatment Study (NordLOTS) in childhood and adolescence. Child Youth Care Forum 39(2):91–99CrossRef Ivarsson T, Thomsen PH, Dahl K, Valderhaug R, Weidle B, Nissen JB, Englyst I, Christensen K, Torp NC, Melin K (2010) The rationale and some features of the Nordic Long-term OCD Treatment Study (NordLOTS) in childhood and adolescence. Child Youth Care Forum 39(2):91–99CrossRef
40.
go back to reference Thomsen PH, Torp NC, Dahl K, Christensen K, Englyst I, Melin KH, Nissen JB, Hybel KA, Valderhaug R, Weidle B, Skarphedinsson G, von Bahr PL, Ivarsson T (2013) The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods. Child and adolescent psychiatry and mental health 7(1):41. doi:10.1186/1753-2000-7-41 PubMedCentralPubMedCrossRef Thomsen PH, Torp NC, Dahl K, Christensen K, Englyst I, Melin KH, Nissen JB, Hybel KA, Valderhaug R, Weidle B, Skarphedinsson G, von Bahr PL, Ivarsson T (2013) The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods. Child and adolescent psychiatry and mental health 7(1):41. doi:10.​1186/​1753-2000-7-41 PubMedCentralPubMedCrossRef
41.
go back to reference Torp NC, Dahl K, Skarphedinsson G, Thomsen PH, Valderhaug R, Weidle B, Melin K, Hybel K, Nissen JB, Lenhard F, Wentzel-Larsen T, Franklin ME, Ivarsson T (2014) Effectiveness of cognitive behavior treatment for pediatric obsessive-compulsive disorder: acute outcomes from the nordic long-term OCD Treatment Study (NordLOTS). Behav Res Ther Forthcom. doi:10.1016/j.brat.2014.11.005 Torp NC, Dahl K, Skarphedinsson G, Thomsen PH, Valderhaug R, Weidle B, Melin K, Hybel K, Nissen JB, Lenhard F, Wentzel-Larsen T, Franklin ME, Ivarsson T (2014) Effectiveness of cognitive behavior treatment for pediatric obsessive-compulsive disorder: acute outcomes from the nordic long-term OCD Treatment Study (NordLOTS). Behav Res Ther Forthcom. doi:10.​1016/​j.​brat.​2014.​11.​005
42.
go back to reference March JS, Mulle K, Foa E, Kozak MJ (2000) Treatment of pediatric obsessive-compulsive disorder cognitive behavior therapy treatment manual March JS, Mulle K, Foa E, Kozak MJ (2000) Treatment of pediatric obsessive-compulsive disorder cognitive behavior therapy treatment manual
43.
go back to reference Piacentini J, Langley A, Roblek T (2007) Cognitive behavioral treatment of childhood OCD: it’s only a false alarm : therapist guide. Oxford University Press, New York Piacentini J, Langley A, Roblek T (2007) Cognitive behavioral treatment of childhood OCD: it’s only a false alarm : therapist guide. Oxford University Press, New York
44.
go back to reference Hollingshead AB (2011) Four factor index of social status Yale. J Sociol 8:21–52 Hollingshead AB (2011) Four factor index of social status Yale. J Sociol 8:21–52
49.
go back to reference Bullinger M, Brutt AL, Erhart M, Ravens-Sieberer U, Group BS (2008) Psychometric properties of the KINDL-R questionnaire: results of the BELLA study. Eur Child Adolesc Psychiatry 17(Suppl 1):125–132. doi:10.1007/s00787-008-1014-z Bullinger M, Brutt AL, Erhart M, Ravens-Sieberer U, Group BS (2008) Psychometric properties of the KINDL-R questionnaire: results of the BELLA study. Eur Child Adolesc Psychiatry 17(Suppl 1):125–132. doi:10.​1007/​s00787-008-1014-z
50.
go back to reference Solans M, Pane S, Estrada MD, Serra-Sutton V, Berra S, Herdman M, Alonso J, Rajmil L (2008) Health-related quality of life measurement in children and adolescents: a systematic review of generic and disease-specific instruments. Value Health 11(4):742–764. doi:10.1111/j.1524-4733.2007.00293.x PubMedCrossRef Solans M, Pane S, Estrada MD, Serra-Sutton V, Berra S, Herdman M, Alonso J, Rajmil L (2008) Health-related quality of life measurement in children and adolescents: a systematic review of generic and disease-specific instruments. Value Health 11(4):742–764. doi:10.​1111/​j.​1524-4733.​2007.​00293.​x PubMedCrossRef
51.
go back to reference Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36(7):980–988. doi:10.1097/00004583-199707000-00021 PubMedCrossRef Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36(7):980–988. doi:10.​1097/​00004583-199707000-00021 PubMedCrossRef
53.
go back to reference Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS (1989) The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability. Arch Gen Psychiatry 46(11):1006–1011PubMedCrossRef Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS (1989) The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability. Arch Gen Psychiatry 46(11):1006–1011PubMedCrossRef
54.
56.
go back to reference Calvocoressi L, Mazure CM, Kasl SV, Skolnick J, Fisk D, Vegso SJ, Van Noppen BL, Price LH (1999) Family accommodation of obsessive-compulsive symptoms: Instrument development and assessment of family behavior. J Nerv Ment Dis 187(10):636–642. doi:10.1097/00005053-199910000-00008 PubMedCrossRef Calvocoressi L, Mazure CM, Kasl SV, Skolnick J, Fisk D, Vegso SJ, Van Noppen BL, Price LH (1999) Family accommodation of obsessive-compulsive symptoms: Instrument development and assessment of family behavior. J Nerv Ment Dis 187(10):636–642. doi:10.​1097/​00005053-199910000-00008 PubMedCrossRef
58.
go back to reference Storch EA, Geffken GR, Merlo LJ, Jacob ML, Murphy TK, Goodman WK, Larson MJ, Fernandez M, Grabill K (2007) Family accommodation in pediatric obsessive-compulsive disorder. J Clinic Child Adolesc Psychol 36(2):207–216CrossRef Storch EA, Geffken GR, Merlo LJ, Jacob ML, Murphy TK, Goodman WK, Larson MJ, Fernandez M, Grabill K (2007) Family accommodation in pediatric obsessive-compulsive disorder. J Clinic Child Adolesc Psychol 36(2):207–216CrossRef
59.
go back to reference Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, Aluwahlia S (1983) A Children’s Global Assessment Scale (CGAS). Arch Gen Psychiatry 40(11):1228–1231PubMedCrossRef Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, Aluwahlia S (1983) A Children’s Global Assessment Scale (CGAS). Arch Gen Psychiatry 40(11):1228–1231PubMedCrossRef
60.
go back to reference Bird HR, Canino G, Rubio-Stipec M, Ribera JC (1987) Further measures of the psychometric properties of the Children’s Global Assessment Scale. Arch Gen Psychiatry 44(9):821–824PubMedCrossRef Bird HR, Canino G, Rubio-Stipec M, Ribera JC (1987) Further measures of the psychometric properties of the Children’s Global Assessment Scale. Arch Gen Psychiatry 44(9):821–824PubMedCrossRef
63.
go back to reference Huppert JD, Simpson HB, Nissenson KJ, Liebowitz MR, Foa EB (2009) Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls. Depress Anxiety 26(1):39–45. doi:10.1002/da.20506 PubMedCentralPubMedCrossRef Huppert JD, Simpson HB, Nissenson KJ, Liebowitz MR, Foa EB (2009) Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls. Depress Anxiety 26(1):39–45. doi:10.​1002/​da.​20506 PubMedCentralPubMedCrossRef
65.
go back to reference Pallanti S, Hollander E, Bienstock C, Koran L, Leckman J, Marazziti D, Pato M, Stein D, Zohar J (2002) Treatment non-response in OCD: methodological issues and operational definitions. Int J Neuropsychopharmacol 5(2):181–191. doi:10.1017/S1461145702002900 PubMedCrossRef Pallanti S, Hollander E, Bienstock C, Koran L, Leckman J, Marazziti D, Pato M, Stein D, Zohar J (2002) Treatment non-response in OCD: methodological issues and operational definitions. Int J Neuropsychopharmacol 5(2):181–191. doi:10.​1017/​S146114570200290​0 PubMedCrossRef
66.
go back to reference Tolin DF, Abramowitz JS, Diefenbach GJ (2005) Defining response in clinical trials for obsessive-compulsive disorder: a signal detection analysis of the Yale-Brown Obsessive Compulsive Scale. J Clin Psychiatry 66(12):1549–1557PubMedCrossRef Tolin DF, Abramowitz JS, Diefenbach GJ (2005) Defining response in clinical trials for obsessive-compulsive disorder: a signal detection analysis of the Yale-Brown Obsessive Compulsive Scale. J Clin Psychiatry 66(12):1549–1557PubMedCrossRef
67.
go back to reference Franklin ME, Sapyta J, Freeman JB, Khanna M, Compton S, Almirall D, Moore P, Choate-Summers M, Garcia A, Edson AL, Foa EB, March JS (2011) Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the pediatric OCD treatment study II (POTS II) randomized controlled trial. JAMA 306(11):1224–1232. doi:10.1001/jama.2011.1344 PubMedCentralPubMedCrossRef Franklin ME, Sapyta J, Freeman JB, Khanna M, Compton S, Almirall D, Moore P, Choate-Summers M, Garcia A, Edson AL, Foa EB, March JS (2011) Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the pediatric OCD treatment study II (POTS II) randomized controlled trial. JAMA 306(11):1224–1232. doi:10.​1001/​jama.​2011.​1344 PubMedCentralPubMedCrossRef
68.
go back to reference Bystritsky A, Liberman RP, Hwang S, Wallace CJ, Vapnik T, Maindment K, Saxena S (2001) Social functioning and quality of life comparisons between obsessive-compulsive and schizophrenic disorders. Depress Anxiety 14(4):214–218PubMedCrossRef Bystritsky A, Liberman RP, Hwang S, Wallace CJ, Vapnik T, Maindment K, Saxena S (2001) Social functioning and quality of life comparisons between obsessive-compulsive and schizophrenic disorders. Depress Anxiety 14(4):214–218PubMedCrossRef
69.
70.
71.
go back to reference Bernard BA, Stebbins GT, Siegel S, Schultz TM, Hays C, Morrissey MJ, Leurgans S, Goetz CG (2009) Determinants of quality of life in children with Gilles de la Tourette syndrome. Mov Disord 24(7):1070–1073. doi:10.1002/mds.22487 PubMedCrossRef Bernard BA, Stebbins GT, Siegel S, Schultz TM, Hays C, Morrissey MJ, Leurgans S, Goetz CG (2009) Determinants of quality of life in children with Gilles de la Tourette syndrome. Mov Disord 24(7):1070–1073. doi:10.​1002/​mds.​22487 PubMedCrossRef
73.
go back to reference Eddy CM, Cavanna AE, Gulisano M, Agodi A, Barchitta M, Cali P, Robertson MM, Rizzo R (2011) Clinical correlates of quality of life in Tourette syndrome. Mov Disord 26(4):735–738. doi:10.1002/mds.23434 PubMedCrossRef Eddy CM, Cavanna AE, Gulisano M, Agodi A, Barchitta M, Cali P, Robertson MM, Rizzo R (2011) Clinical correlates of quality of life in Tourette syndrome. Mov Disord 26(4):735–738. doi:10.​1002/​mds.​23434 PubMedCrossRef
74.
75.
go back to reference Eddy CM, Cavanna AE, Gulisano M, Cali P, Robertson MM, Rizzo R (2012) The effects of comorbid obsessive-compulsive disorder and attention-deficit hyperactivity disorder on quality of life in tourette syndrome. J Neuropsychiatry Clin Neurosci 24(4):458–462. doi:10.1176/appi.neuropsych.11080181 PubMedCrossRef Eddy CM, Cavanna AE, Gulisano M, Cali P, Robertson MM, Rizzo R (2012) The effects of comorbid obsessive-compulsive disorder and attention-deficit hyperactivity disorder on quality of life in tourette syndrome. J Neuropsychiatry Clin Neurosci 24(4):458–462. doi:10.​1176/​appi.​neuropsych.​11080181 PubMedCrossRef
76.
go back to reference Storch EA, Lewin AB, Farrell L, Aldea MA, Reid J, Geffken GR, Murphy TK (2010) Does cognitive-behavioral therapy response among adults with obsessive-compulsive disorder differ as a function of certain comorbidities? J Anxiety Disord 24(6):547–552. doi:10.1016/j.janxdis.2010.03.013 PubMedCrossRef Storch EA, Lewin AB, Farrell L, Aldea MA, Reid J, Geffken GR, Murphy TK (2010) Does cognitive-behavioral therapy response among adults with obsessive-compulsive disorder differ as a function of certain comorbidities? J Anxiety Disord 24(6):547–552. doi:10.​1016/​j.​janxdis.​2010.​03.​013 PubMedCrossRef
77.
go back to reference Lack CW, Yardley HL, Dalaya A (2013) Treatment of multiple co-morbid anxiety disorders. In: Storch EA, McKay D (eds) Handbook of treating variants and complications in anxiety disorders. Springer, New York Lack CW, Yardley HL, Dalaya A (2013) Treatment of multiple co-morbid anxiety disorders. In: Storch EA, McKay D (eds) Handbook of treating variants and complications in anxiety disorders. Springer, New York
78.
go back to reference Storch EA, Merlo LJ, Larson MJ, Geffken GR, Lehmkuhl HD, Jacob ML, Murphy TK, Goodman WK (2008) Impact of comorbidity on cognitive-behavioral therapy response in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 47(5):583–592. doi:10.1097/CHI.0b013e31816774b1 PubMedCrossRef Storch EA, Merlo LJ, Larson MJ, Geffken GR, Lehmkuhl HD, Jacob ML, Murphy TK, Goodman WK (2008) Impact of comorbidity on cognitive-behavioral therapy response in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 47(5):583–592. doi:10.​1097/​CHI.​0b013e31816774b1​ PubMedCrossRef
Metadata
Title
Quality of life in children with OCD before and after treatment
Authors
Bernhard Weidle
Tord Ivarsson
Per Hove Thomsen
Stian Lydersen
Thomas Jozefiak
Publication date
01-09-2015
Publisher
Springer Berlin Heidelberg
Published in
European Child & Adolescent Psychiatry / Issue 9/2015
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-014-0659-z

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