Skip to main content
Top
Published in: European Child & Adolescent Psychiatry 4/2013

01-04-2013 | Brief Report

Depression with psychotic features in a child with SLE: successful therapy with psychotropic medications—case report

Authors: Milica Pejovic Milovancevic, Vladimir Miletic, Smiljka Popovic Deusic, Saveta Draganic Gajic, Dusica Lecic Tosevski

Published in: European Child & Adolescent Psychiatry | Issue 4/2013

Login to get access

Abstract

Systemic lupus erythematosus (SLE) is a multisystemic, autoimmune disease of unknown etiology, which affects multiple organ systems, including the central nervous system (CNS). Neuropsychiatric manifestations are seen in 13–75 % of all SLE patients, with equal frequency in children and adults. Despite a high prevalence of psychiatric manifestations, there is no consensus on the proper treatment of such cases. We report here a case of an 11-year-old girl diagnosed with a severe depressive episode with psychotic features, treated successfully with risperidone and sertraline as an adjunct to immunosuppressive therapy.
Literature
1.
3.
go back to reference Vadacca M, Buzzulini F, Rigon A et al (2006) Il lupus neuropsichiatrico. Reumatismo 58(3):177–186PubMed Vadacca M, Buzzulini F, Rigon A et al (2006) Il lupus neuropsichiatrico. Reumatismo 58(3):177–186PubMed
5.
go back to reference Rutter M, Bishop D, Pine D, Scott S, Stevenson JS et al (2008) Rutter’s child and adolescent psychiatry. Blackwell, LondonCrossRef Rutter M, Bishop D, Pine D, Scott S, Stevenson JS et al (2008) Rutter’s child and adolescent psychiatry. Blackwell, LondonCrossRef
6.
go back to reference Yu H-H, Wang L-C, Lee J-H, Leel C-C, Yang Y-H et al (2007) Lymphopenia is associated with neuropsychiatric manifestations and disease activity in paediatric systemic lupus erythematosus patients. Rheumatology 46:1492–1494PubMedCrossRef Yu H-H, Wang L-C, Lee J-H, Leel C-C, Yang Y-H et al (2007) Lymphopenia is associated with neuropsychiatric manifestations and disease activity in paediatric systemic lupus erythematosus patients. Rheumatology 46:1492–1494PubMedCrossRef
7.
go back to reference Gono T, Kawaguchi Y, Kaneko H, Nishimura K, Hanaoka M et al (2011) Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus. Rheumatology (Oxford) 50(9):1578–1585CrossRef Gono T, Kawaguchi Y, Kaneko H, Nishimura K, Hanaoka M et al (2011) Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus. Rheumatology (Oxford) 50(9):1578–1585CrossRef
8.
go back to reference Muscal E, Nadeem T, Li X, Mian A, Harris TB (2010) Evaluation and treatment of acute psychosis in children with systemic lupus erythematosus (SLE): consultation-liaison service experiences at a tertiary-care pediatric institution. Psychosomatics 51(6):508–514PubMed Muscal E, Nadeem T, Li X, Mian A, Harris TB (2010) Evaluation and treatment of acute psychosis in children with systemic lupus erythematosus (SLE): consultation-liaison service experiences at a tertiary-care pediatric institution. Psychosomatics 51(6):508–514PubMed
9.
go back to reference Muscal E, Bang L, Mian A, Harris TB (2011) Use of aripiprazole in adolescents with a history of lupus-associated psychosis and refractory psychiatric manifestations. J Psychiatr Pract 17(3):212–216PubMedCrossRef Muscal E, Bang L, Mian A, Harris TB (2011) Use of aripiprazole in adolescents with a history of lupus-associated psychosis and refractory psychiatric manifestations. J Psychiatr Pract 17(3):212–216PubMedCrossRef
10.
go back to reference Chun S, McEvilly R, Foster JA, Sakic B (2008) Proclivity to self-injurious behavior in MRL-lpr mice: implications for autoimmunity-induced damage in the dopaminergic system. Mol Psychiatry 13(11):1043–1053PubMedCrossRef Chun S, McEvilly R, Foster JA, Sakic B (2008) Proclivity to self-injurious behavior in MRL-lpr mice: implications for autoimmunity-induced damage in the dopaminergic system. Mol Psychiatry 13(11):1043–1053PubMedCrossRef
12.
go back to reference Amminger GP, Schlögelhofer M, Lehner T (2000) Premorbid performance IQ deficit in schizophrenia. Acta Psychiatr Scand 102(6):414–422PubMedCrossRef Amminger GP, Schlögelhofer M, Lehner T (2000) Premorbid performance IQ deficit in schizophrenia. Acta Psychiatr Scand 102(6):414–422PubMedCrossRef
13.
go back to reference Moorthy LN, Peterson M, Onel KB, Harrison MJ, Lehman TJ (2005) Quality of life in children with systemic lupus erythematosus. Curr Rheumatol Rep 7(6):447–452PubMedCrossRef Moorthy LN, Peterson M, Onel KB, Harrison MJ, Lehman TJ (2005) Quality of life in children with systemic lupus erythematosus. Curr Rheumatol Rep 7(6):447–452PubMedCrossRef
14.
go back to reference Iverson GL, Mendrek A, Adams RL (2004) The persistent belief that VIQ-PIQ splits suggest lateralized brain damage. Appl Neuropsychol 11(2):85–90PubMedCrossRef Iverson GL, Mendrek A, Adams RL (2004) The persistent belief that VIQ-PIQ splits suggest lateralized brain damage. Appl Neuropsychol 11(2):85–90PubMedCrossRef
15.
go back to reference Ryan JJ, Paolo AM, Van Fleet JN (1994) Neurodiagnostic implications of abnormal verbal-performance IQ discrepancies on the WAIS-R: a comparison with the standardization sample. Arch Clin Neuropsychol 9(3):251–258PubMed Ryan JJ, Paolo AM, Van Fleet JN (1994) Neurodiagnostic implications of abnormal verbal-performance IQ discrepancies on the WAIS-R: a comparison with the standardization sample. Arch Clin Neuropsychol 9(3):251–258PubMed
16.
go back to reference Fuerst DR, Fisk JL, Rourke BP (1990) Psychosocial functioning of learning-disabled children: relations between WISC verbal IQ-Performance IQ discrepancies and personality subtypes. J Consult Clin Psychol 58(5):657–660PubMedCrossRef Fuerst DR, Fisk JL, Rourke BP (1990) Psychosocial functioning of learning-disabled children: relations between WISC verbal IQ-Performance IQ discrepancies and personality subtypes. J Consult Clin Psychol 58(5):657–660PubMedCrossRef
17.
go back to reference Mulherin D, Doherty E, O’Connell A, Bresnihan B (1993) Assessment of cognitive function in patients with systemic lupus erythematosus. Ir J Med Sci 162(1):9–12PubMedCrossRef Mulherin D, Doherty E, O’Connell A, Bresnihan B (1993) Assessment of cognitive function in patients with systemic lupus erythematosus. Ir J Med Sci 162(1):9–12PubMedCrossRef
18.
go back to reference Carlomagno S, Migliaresi S, Ambrosone L, Sannino M, Sanges G, Di Iorio G (2000) Cognitive impairment in systemic lupus erythematosus: a follow-up study. J Neurol 247(4):273–279PubMedCrossRef Carlomagno S, Migliaresi S, Ambrosone L, Sannino M, Sanges G, Di Iorio G (2000) Cognitive impairment in systemic lupus erythematosus: a follow-up study. J Neurol 247(4):273–279PubMedCrossRef
19.
go back to reference Appenzeller S, Bonilha L, Rio PA, Min Li L, Costallat LT, Cendes F (2007) Longitudinal analysis of gray and white matter loss in patients with systemic lupus erythematosus. Neuroimage 34(2):694–701PubMedCrossRef Appenzeller S, Bonilha L, Rio PA, Min Li L, Costallat LT, Cendes F (2007) Longitudinal analysis of gray and white matter loss in patients with systemic lupus erythematosus. Neuroimage 34(2):694–701PubMedCrossRef
20.
Metadata
Title
Depression with psychotic features in a child with SLE: successful therapy with psychotropic medications—case report
Authors
Milica Pejovic Milovancevic
Vladimir Miletic
Smiljka Popovic Deusic
Saveta Draganic Gajic
Dusica Lecic Tosevski
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
European Child & Adolescent Psychiatry / Issue 4/2013
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-012-0330-5

Other articles of this Issue 4/2013

European Child & Adolescent Psychiatry 4/2013 Go to the issue