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01-12-2011 | Brief Report

No significant association between Catechol-O-methyl transferase (COMT) −287A/G gene polymorphism and Tourette’s syndrome in family-based association study in Chinese Han population

Authors: Shiguo Liu, Mingji Yi, Fengguang Qi, Yuping Sun, Fengyuan Che, Xu Ma

Published in: European Child & Adolescent Psychiatry | Issue 11-12/2011

Abstract

To identify the association of Catechol-O-methyl transferase (COMT) −287A/G polymorphism with susceptibility to TS in Chinese Han population. We evaluated the genetic contribution of the COMT −287A/G polymorphism in 108 TS patients including all their parents in Chinese Han population using transmission disequilibrium test and haplotype relative risk design. Our results revealed that no significant association was found in COMT −287A/G genotypic and allelic frequencies with TS. Our results also suggested that there may be a lack of association between the TS and −287A/G polymorphism of COMT in Chinese Han population.

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Title: No significant association between Catechol-O-methyl transferase (COMT) −287A/G gene polymorphism and Tourette’s syndrome in family-based association study in Chinese Han population
Authors: Shiguo Liu
Mingji Yi
Fengguang Qi
Yuping Sun
Fengyuan Che
Xu Ma
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: European Child & Adolescent Psychiatry / Issue 11-12/2011
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-011-0226-9

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No significant association between Catechol-O-methyl transferase (COMT) −287A/G gene polymorphism and Tourette’s syndrome in family-based association study in Chinese Han population

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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