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01-03-2010 | Review

Genetics of early-onset obsessive–compulsive disorder

Authors: Susanne Walitza, Jens R. Wendland, Edna Gruenblatt, Andreas Warnke, Thomas A. Sontag, Oliver Tucha, Klaus W. Lange

Published in: European Child & Adolescent Psychiatry | Issue 3/2010

Abstract

Obsessive–compulsive disorder (OCD) is characterized by recurrent, intrusive and disturbing thoughts as well as by repetitive stereotypic behaviors. Epidemiological data are similar in children and adults, i.e., between 1 and 3% of the general population suffer from OCD. Children with OCD are often seriously impaired in their development. OCD, especially of early onset, has been shown to be familial. Several candidate genes of predominantly neurotransmitter systems have been analyzed and a total of three genome-wide linkage scans have been performed until now. Analyses of candidate genes in linkage regions have not provided evidence for their involvement in OCD, with the exception of the glutamate transporter gene SLC1A1 on 9p24. Genome-wide association analyses are in progress and the results will promote further independent replication studies. The consideration of subtypes regarding age of onset, symptom dimensions and/or comorbid disorders is needed.

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Title: Genetics of early-onset obsessive–compulsive disorder
Authors: Susanne Walitza
Jens R. Wendland
Edna Gruenblatt
Andreas Warnke
Thomas A. Sontag
Oliver Tucha
Klaus W. Lange
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: European Child & Adolescent Psychiatry / Issue 3/2010
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-010-0087-7

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Springer Medicine

Genetics of early-onset obsessive–compulsive disorder

Abstract

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Abstract

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