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Open Access 01-10-2006 | ORIGINAL CONTRIBUTION

Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients

Authors: Silke Klemm, PhD, Beate Schmidt, MD, Susanne Knappe, Bernhard Blanz, MD

Published in: European Child & Adolescent Psychiatry | Issue 7/2006

Abstract

The aim of the investigation was to detect neuropsychological markers, such as sustained and selective attention and executive functions, which contribute to the vulnerability to schizophrenia especially in young persons. Performance was assessed in 32 siblings and children of schizophrenic patients and 32 matched controls using Wisconsin Card Sorting Test, Colour-Word-Interference-Test, Trail Making Test, and d2-Concentration-Test. The first-degree relatives showed certain impairments on all four tests, in particular, slower times on all time-limited tests. These results suggest the need for more time when completing neuropsychological tasks involving selected and focused attention, as well as cognitive flexibility, as a possible indicator of genetic vulnerability to schizophrenia.

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Title: Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients
Authors: Silke Klemm, PhD
Beate Schmidt, MD
Susanne Knappe
Bernhard Blanz, MD
Publication date: 01-10-2006
Publisher: Steinkopff-Verlag
Published in: European Child & Adolescent Psychiatry / Issue 7/2006
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-006-0547-2

At a glance: The STEP trials

Springer Medicine

Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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