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European Child & Adolescent Psychiatry
Published in: European Child & Adolescent Psychiatry 3/2006

01-04-2006 | ORIGINAL CONTRIBUTION

Antipsychotics in early onset Schizophrenia

Systematic review and meta-analysis

Authors: Jorge L. Armenteros, Mark Davies

Published in: European Child & Adolescent Psychiatry | Issue 3/2006

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Abstract

Background

To develop an evidence base for using antipsychotic medications for schizophrenia in children and adolescents.

Method

Data sources were identified in PsychINFO (1872–2003), MEDLINE (1966–2003), and articles in reference lists. Study selection criteria: (1) treatment with antipsychotics; (2) ages were between 5 and 18 years; (3) sample diagnosed with schizophrenia; (4) prospective design; (5) rating instruments used. Fifteen studies met inclusion criteria and were rated. Study quality was independently rated.

Results

Average response rate among 8 studies employing atypicals was 55.7% compared to 72.3% among 13 studies employing typicals. The difference was statistically different at the trend level (z=1.65, P<0.10). The effect size on a continuous measure was 0.36 in favor of typicals. When study quality was included in the model, the effect of medication type remained unchanged. Average weight gain in patients treated with typicals was 1.4 Kg. compared to 4.5 Kg for those treated with atypicals. Sedation was more common among those on atypicals. The rate of extrapyramidal side effects was similar among the two groups

Conclusions

Antipsychotic medications seem effective for schizophrenia treatment in children and adolescents. Typicals appear to be more effective and cause less weight gain than atypicals. However, more rigorous clinical trials are necessary.
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Metadata
Title
Antipsychotics in early onset Schizophrenia
Systematic review and meta-analysis
Authors
Jorge L. Armenteros
Mark Davies
Publication date
01-04-2006
Publisher
Steinkopff-Verlag
Published in
European Child & Adolescent Psychiatry / Issue 3/2006
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-005-0515-2

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