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01-10-2021 | Review

Genetic variation involved in the risk to external apical root resorption in orthodontic patients: a systematic review

Authors: Liz Helena Moraes Pinheiro, Ludmila Silva Guimarães, Leonardo Santos Antunes, Erika Calvano Küchler, Christian Kirschneck, Lívia Azeredo Alves Antunes

Published in: Clinical Oral Investigations | Issue 10/2021

Abstract

Objective

To perform a systematic review/meta-analysis to elucidate the scientific basis for the association between genetic variations and risk of external apical root resorption (EARR) in orthodontic patients.

Materials and methods

Four databases (PubMed, Web of Science, Scopus, LILACS) were electronically searched until November 22, 2020, followed by manual and gray literature search. Case-control or cross-sectional studies that evaluated genes involved in the susceptibility of orthodontic patients to EARR were eligible. Two reviewers applied the inclusion and exclusion criteria, extracted qualitative data, as well as assessed methodological quality using instrument proposed for genetic studies. For synthesis results, narrative and quantitative data (meta-analysis) were performed. The certainty of the evidence was tested using the GRADE Working Group approach.

Results

Of 201 articles in total, 16 studies were included in the review. Of these, 11 presented moderate and 5 of high methodological quality. In the narrative analysis, from 16 studies, 15 studies (10 genes) showed a significant association with EARR and 9 studies were included in the meta-analysis. Only the polymorphism rs208294 in P2RX7 (dominant model) was associated with EARR (OR = 0.52, 95%CI = 0.29–0.95, p = 0.03) and presented a very low certainty of the evidence.

Conclusion

Narrative analyses of individual studies demonstrated an association of many genes. The number of studies for each genetic variation was very low, and methodological heterogeneity between the studies was observed. Quantitative analyses (meta-analysis) could only show an involvement for P2RX7 (rs208294) in the risk of orthodontic patients to EARR at a very low certainty of evidence. (CRD42018085411).

Clinical relevance

The knowledge regarding the molecular aspects involved in the etiology of EARR will allow orthodontists to use a personalized treatment and early diagnosis of risk patients. This systematic review demonstrates that more studies are necessary to unravel the role of genetic variation for patients’ risk to EARR during orthodontic tooth movement.

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Title: Genetic variation involved in the risk to external apical root resorption in orthodontic patients: a systematic review
Authors: Liz Helena Moraes Pinheiro
Ludmila Silva Guimarães
Leonardo Santos Antunes
Erika Calvano Küchler
Christian Kirschneck
Lívia Azeredo Alves Antunes
Publication date: 01-10-2021
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 10/2021
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-021-04074-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Genetic variation involved in the risk to external apical root resorption in orthodontic patients: a systematic review

Abstract

Objective

Materials and methods

Results

Conclusion

Clinical relevance

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

Clinical relevance

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