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Open Access 01-11-2018 | Short Communication

Dental radiographic findings in 18 individuals with SATB2-associated syndrome

Authors: John Scott, Chad Adams, Kirt Simmons, Andrea Feather, John Jones, Larry Hartzell, Lucia Wesley, Adam Johnson, Jennifer Fish, Katherine Bosanko, Stephen Beetstra, Yuri A. Zarate

Published in: Clinical Oral Investigations | Issue 8/2018

Abstract

Objective

To characterize the radiographic dental phenotype of individuals with SATB2-associated syndrome (SAS).

Materials and methods

Participants were evaluated by a multidisciplinary team during a concurrent clinic conducted during the 1st international SAS family meeting held in 2017 at a single institution. Whenever possible, panoramic and/or periapical radiographs were obtained in clinic or previously obtained and provided by the caregiver.

Results

Of the 37 individuals evaluated, 18 (12 males, median age 8.5 years) underwent radiographic examination. Dental radiographs revealed anomalies in all individuals starting at 2 years of age. The most consistent finding was delayed development of the mandibular second bicuspids (83%) with other common radiographic findings including delayed development of the roots of the permanent teeth (78%), severely rotated (56%) or malformed teeth (44%), and taurodontism (44%).

Conclusions

Dental anomalies are fully penetrant and can be documented radiographically in all individuals with SAS.

Clinical relevance

Dental radiographic findings of delayed second premolar development and delayed development of permanent root formation, especially concurrent with findings of taurodontism and malformed teeth, support a clinical suspicion for SAS and should help differentiate SAS from other neurodevelopmental syndromes.

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Title: Dental radiographic findings in 18 individuals with SATB2-associated syndrome
Authors: John Scott
Chad Adams
Kirt Simmons
Andrea Feather
John Jones
Larry Hartzell
Lucia Wesley
Adam Johnson
Jennifer Fish
Katherine Bosanko
Stephen Beetstra
Yuri A. Zarate
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 8/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2702-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Dental radiographic findings in 18 individuals with SATB2-associated syndrome

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

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