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Published in: Clinical Oral Investigations 5/2019

01-05-2019 | Original Article

Postoperative morbidity of free flaps in head and neck cancer reconstruction: a report regarding 215 cases

Authors: Maria Poisson, Julie Longis, Matthias Schlund, Morgane Pere, Guillaume Michel, Antoine Delagranda, François Mouawad, Benoit Piot, Hélios Bertin

Published in: Clinical Oral Investigations | Issue 5/2019

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Abstract

Objectives

The aim of this study was to identify the factors responsible for free flap failure, the surgical complications, and the non-oral feeding period in patients treated for an oral squamous cell carcinoma.

Materials and methods

This multicentric study included 215 patients treated by tumour resection with immediate free flap reconstruction for an OSCC between 2010 and 2016. All of the patient medical files were reviewed and the data regarding the patient medical history, the tumour-related features, the surgical procedure, and the postoperative recovery were compiled. A statistical analysis with univariate and multivariate logistic regression was carried out.

Results

The free flap success rate was 94.4% in our series. A postoperative complication occurred in 101 patients (41%). Minor surgical complications were shown to increase the free flap failure rate (OR 3.32; p = 0.04). A major surgical complication was encountered in 48 patients (22.3%), and these were linked to minor surgical complications (OR 2.89; p = 0.004) and the use of a tracheostomy (OR 5.76, p = 0.002). Conversely, a medical history of high blood pressure had a protective effect (p = 0.04). The non-oral feeding rate at the end of the hospital stay was 28.4%, and it correlated with the tracheostomy (p = 0.002), as well as the major and the minor surgical complications (p = 0.04).

Conclusion-clinical relevance

Free flap reconstruction is a safe and reliable technique with head and neck cancer reconstruction. Postoperative care favouring early and safe oral-feeding, and avoiding a tracheostomy can reduce the incidence of surgical complications after OSCC reconstruction.
Literature
1.
go back to reference HAS-Institut National du Cancer (2009) Guide ALD-Tumeur maligne, affection maligne du tissu lymphatique et hématopoïétique. In: Cancer des voies aéro-digestives supérieures HAS-Institut National du Cancer (2009) Guide ALD-Tumeur maligne, affection maligne du tissu lymphatique et hématopoïétique. In: Cancer des voies aéro-digestives supérieures
9.
go back to reference Patel RS, McCluskey SA, Goldstein DP, Minkovich L, Irish JC, Brown DH et al (2010) Clinicopathologic and therapeutic risk factors for perioperative complications and prolonged hospital stay in free flap reconstruction of the head and neck. Head Neck 32:1345–1353. https://doi.org/10.1002/hed.21331 CrossRefPubMed Patel RS, McCluskey SA, Goldstein DP, Minkovich L, Irish JC, Brown DH et al (2010) Clinicopathologic and therapeutic risk factors for perioperative complications and prolonged hospital stay in free flap reconstruction of the head and neck. Head Neck 32:1345–1353. https://​doi.​org/​10.​1002/​hed.​21331 CrossRefPubMed
13.
go back to reference Disa JJ, Pusic AL, Hidalgo DH, Cordeiro PG (2001) Simplifying microvascular head and neck reconstruction: a rational approach to donor site selection. Ann Plast Surg 47:385–389CrossRefPubMed Disa JJ, Pusic AL, Hidalgo DH, Cordeiro PG (2001) Simplifying microvascular head and neck reconstruction: a rational approach to donor site selection. Ann Plast Surg 47:385–389CrossRefPubMed
14.
go back to reference Cordeiro PG, Hidalgo DA (1995) Conceptual considerations in mandibular reconstruction. Clin Plast Surg 22:61–69PubMed Cordeiro PG, Hidalgo DA (1995) Conceptual considerations in mandibular reconstruction. Clin Plast Surg 22:61–69PubMed
15.
go back to reference Singh B, Cordeiro PG, Santamaria E, Shaha AR, Pfister DG, Shah JP (1999) Factors associated with complications in microvascular reconstruction of head and neck defects. Plast Reconstr Surg 103:403–411CrossRefPubMed Singh B, Cordeiro PG, Santamaria E, Shaha AR, Pfister DG, Shah JP (1999) Factors associated with complications in microvascular reconstruction of head and neck defects. Plast Reconstr Surg 103:403–411CrossRefPubMed
16.
go back to reference Schultze-Mosgau S, Grabenbauer GG, Radespiel-Tröger M, Wiltfang J, Ries J, Neukam FW et al (2002) Vascularization in the transition area between free grafted soft tissues and pre-irradiated graft bed tissues following preoperative radiotherapy in the head and neck region. Head Neck 24:42–51CrossRefPubMed Schultze-Mosgau S, Grabenbauer GG, Radespiel-Tröger M, Wiltfang J, Ries J, Neukam FW et al (2002) Vascularization in the transition area between free grafted soft tissues and pre-irradiated graft bed tissues following preoperative radiotherapy in the head and neck region. Head Neck 24:42–51CrossRefPubMed
17.
go back to reference Peng X, Yu J, Li Z, Zhou X, Chen J, Dai J et al (2015) Analysis of the causes of flap necrosis after head and neck reconstruction. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 50:118–122PubMed Peng X, Yu J, Li Z, Zhou X, Chen J, Dai J et al (2015) Analysis of the causes of flap necrosis after head and neck reconstruction. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 50:118–122PubMed
19.
go back to reference Bozec A, Poissonnet G, Chamorey E, Laout C, Vallicioni J, Demard F, Peyrade F, Follana P, Bensadoun RJ, Benezery K, Thariat J, Marcy PY, Sudaka A, Dassonville O (2009) Radical ablative surgery and radial forearm free flap (RFFF) reconstruction for patients with oral or oropharyngeal cancer: postoperative outcomes and oncologic and functional results. Acta Otolaryngol (Stockh) 129:681–687. https://doi.org/10.1080/00016480802369260 CrossRef Bozec A, Poissonnet G, Chamorey E, Laout C, Vallicioni J, Demard F, Peyrade F, Follana P, Bensadoun RJ, Benezery K, Thariat J, Marcy PY, Sudaka A, Dassonville O (2009) Radical ablative surgery and radial forearm free flap (RFFF) reconstruction for patients with oral or oropharyngeal cancer: postoperative outcomes and oncologic and functional results. Acta Otolaryngol (Stockh) 129:681–687. https://​doi.​org/​10.​1080/​0001648080236926​0 CrossRef
21.
go back to reference Nao EEM, Dassonville O, Poissonnet G, Chamorey E, Pierre C-S, Riss J-C, Vincent N, Peyrade F, Benezery K, Chemaly L, Sudaka A, Marcy PY, Vallicioni J, Demard F, Santini J, Bozec A (2011) Ablative surgery and free flap reconstruction for elderly patients with oral or oropharyngeal cancer: oncologic and functional outcomes. Acta Otolaryngol (Stockh) 131:1104–1109. https://doi.org/10.3109/00016489.2011.593044 CrossRef Nao EEM, Dassonville O, Poissonnet G, Chamorey E, Pierre C-S, Riss J-C, Vincent N, Peyrade F, Benezery K, Chemaly L, Sudaka A, Marcy PY, Vallicioni J, Demard F, Santini J, Bozec A (2011) Ablative surgery and free flap reconstruction for elderly patients with oral or oropharyngeal cancer: oncologic and functional outcomes. Acta Otolaryngol (Stockh) 131:1104–1109. https://​doi.​org/​10.​3109/​00016489.​2011.​593044 CrossRef
23.
go back to reference TTA P, Post SF, van Dijk BAC, Roodenburg JLN, van der Laan BFAM, Werker PMN et al (2015) Free flap reconstruction for head and neck cancer can be safely performed in both young and elderly patients after careful patient selection. Eur Arch Otorhinolaryngol 272:2999–3005. https://doi.org/10.1007/s00405-014-3268-z CrossRef TTA P, Post SF, van Dijk BAC, Roodenburg JLN, van der Laan BFAM, Werker PMN et al (2015) Free flap reconstruction for head and neck cancer can be safely performed in both young and elderly patients after careful patient selection. Eur Arch Otorhinolaryngol 272:2999–3005. https://​doi.​org/​10.​1007/​s00405-014-3268-z CrossRef
26.
go back to reference Song R, Gao Y, Song Y, Yu Y, Song Y (1982) The forearm flap. Clin Plast Surg 9:21–26PubMed Song R, Gao Y, Song Y, Yu Y, Song Y (1982) The forearm flap. Clin Plast Surg 9:21–26PubMed
27.
go back to reference Hidalgo DA (1989) Fibula free flap: a new method of mandible reconstruction. Plast Reconstr Surg 84:71–79CrossRefPubMed Hidalgo DA (1989) Fibula free flap: a new method of mandible reconstruction. Plast Reconstr Surg 84:71–79CrossRefPubMed
28.
go back to reference Matloub HS, Larson DL, Kuhn JC, Yousif NJ, Sanger JR (1989) Lateral arm free flap in oral cavity reconstruction: a functional evaluation. Head Neck 11:205–211CrossRefPubMed Matloub HS, Larson DL, Kuhn JC, Yousif NJ, Sanger JR (1989) Lateral arm free flap in oral cavity reconstruction: a functional evaluation. Head Neck 11:205–211CrossRefPubMed
33.
go back to reference Shaari CM, Buchbinder D, Costantino PD, Lawson W, Biller HF, Urken ML (1998) Complications of microvascular head and neck surgery in the elderly. Arch Otolaryngol Head Neck Surg 124:407–411CrossRefPubMed Shaari CM, Buchbinder D, Costantino PD, Lawson W, Biller HF, Urken ML (1998) Complications of microvascular head and neck surgery in the elderly. Arch Otolaryngol Head Neck Surg 124:407–411CrossRefPubMed
35.
go back to reference Brugel L, Laurent M, Caillet P, Radenne A, Durand-Zaleski I, Martin M, Baron M, de Kermadec H, Bastuji-Garin S, Canouï-Poitrine F, Paillaud E (2014) Impact of comprehensive geriatric assessment on survival, function, and nutritional status in elderly patients with head and neck cancer: protocol for a multicentre randomised controlled trial (EGeSOR). BMC Cancer 14:427. https://doi.org/10.1186/1471-2407-14-427 CrossRefPubMedPubMedCentral Brugel L, Laurent M, Caillet P, Radenne A, Durand-Zaleski I, Martin M, Baron M, de Kermadec H, Bastuji-Garin S, Canouï-Poitrine F, Paillaud E (2014) Impact of comprehensive geriatric assessment on survival, function, and nutritional status in elderly patients with head and neck cancer: protocol for a multicentre randomised controlled trial (EGeSOR). BMC Cancer 14:427. https://​doi.​org/​10.​1186/​1471-2407-14-427 CrossRefPubMedPubMedCentral
40.
go back to reference Serletti JM, Higgins JP, Moran S, Orlando GS (2000) Factors affecting outcome in free-tissue transfer in the elderly. Plast Reconstr Surg 106:66–70CrossRefPubMed Serletti JM, Higgins JP, Moran S, Orlando GS (2000) Factors affecting outcome in free-tissue transfer in the elderly. Plast Reconstr Surg 106:66–70CrossRefPubMed
43.
go back to reference Bettega et al (2015) Fluorescent angiography for flap planning and monitoring in reconstructive surgery. Fluoresc Imaging Surg Concepts Appl, Switzerland, p. 301 Bettega et al (2015) Fluorescent angiography for flap planning and monitoring in reconstructive surgery. Fluoresc Imaging Surg Concepts Appl, Switzerland, p. 301
Metadata
Title
Postoperative morbidity of free flaps in head and neck cancer reconstruction: a report regarding 215 cases
Authors
Maria Poisson
Julie Longis
Matthias Schlund
Morgane Pere
Guillaume Michel
Antoine Delagranda
François Mouawad
Benoit Piot
Hélios Bertin
Publication date
01-05-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 5/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-018-2653-1

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