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01-01-2019 | Original Article

Comparison of mucosal and mucoperiosteal wound cover for the treatment of medication-related osteonecrosis of the jaw lesions: a retrospective cohort study

Authors: Nicola Nonnenmühlen, A. Burnic, A. Bartella, B. Lethaus, F. Gerhards, O. Ristow, C. Pautke, F. Hölzle, T. Steiner

Published in: Clinical Oral Investigations | Issue 1/2019

Abstract

Objectives

Actually, there is no detailed guidance on how to deal with wound closure after surgical removal of medication-related osteonecrosis of the jaw (MRONJ) lesions. This study attempts to compare the difference in outcome between the mucosal and the mucoperiosteal flap closure after surgery.

Patients and methods

In this retrospective monocentric cohort study, patients (n = 61; 35 female/26 male) suffering from MRONJ and requiring surgical therapy at the University of Aachen between 2013 and 2015 were included. Due to intra-institutional variances, one group was treated with the mucosal, the other group with the mucoperiosteal technique. The success rate, i.e., mucosal closure and no relapse at the point of follow-up, was evaluated and compared. All patients were clinically investigated for the postoperative follow-up during a special consultation appointment.

Results

The success rates between the different techniques after 2 years follow-up were very similar. In the group of mucosal wound closure, 22 of 29 (75.86%) patients revealed mucosal integrity without signs of MRONJ. The rate in the mucoperiosteal wound closure group was almost identical (24 of 32 (75%)).

Conclusion

No differences in the success rates between the two different techniques could be evaluated.

Clinical relevance

The results of this study suggest that the complete removal of the necrotic bone might have a higher impact on the success rates than the technique of the wound closure. Due to the fact that the mucoperiosteal wound closure technique offers a better overview of the extent of the MRONJ lesion, the authors advise to use this technique.

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Title: Comparison of mucosal and mucoperiosteal wound cover for the treatment of medication-related osteonecrosis of the jaw lesions: a retrospective cohort study
Authors: Nicola Nonnenmühlen
A. Burnic
A. Bartella
B. Lethaus
F. Gerhards
O. Ristow
C. Pautke
F. Hölzle
T. Steiner
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 1/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2443-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparison of mucosal and mucoperiosteal wound cover for the treatment of medication-related osteonecrosis of the jaw lesions: a retrospective cohort study

Abstract

Objectives

Patients and methods

Results

Conclusion

Clinical relevance

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Patients and methods

Results

Conclusion

Clinical relevance

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