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01-11-2018 | Original Article

Zinc and silica are active components to efficiently treat in vitro simulated eroded dentin

Authors: Raquel Osorio, Manuel Toledano-Osorio, Estrella Osorio, Fátima S. Aguilera, Sussette Padilla-Mondéjar, Manuel Toledano

Published in: Clinical Oral Investigations | Issue 8/2018

Abstract

Objectives

Biomaterials for treating dentin hypersensitivity and dentin wear were evaluated to efficiently occlude the dentinal tubules and to increase dentin resistance to abrasion.

Materials and methods

Twenty-four dentin surfaces were treated with EDTA to expose dentinal tubules and were (1) non-brushed, (2) brushed with distilled water, or with pastes containing (3) monetite, (4) brushite, (5) Zn-monetite, (6) Zn-brushite, (7) Silica-brushite, and (8) NovaMin®. Topographical, nanomechanical, and chemical analysis were assessed on dentin surfaces (n = 3) after artificial saliva immersion for 24 h, and after citric acid challenge. Twenty-one further dentin specimens were created to evaluate dentin permeability after brushing, saliva storage, and acid application (n = 3). ANOVA, Student-Newman-Keuls (p < 0.05), and Student t test (p < 0.001) were used.

Results

Particles containing major proportion of silica attained intratubular occlusion by carbonate crystals (Raman carbonate peak heights 15.17 and 19.24 au; complex modulus 110 and 140 GPa, at intratubular dentin). When brushing with pastes containing higher proportion of silica or zinc, phosphate calcium compounds were encountered into tubules and over dentin surfaces (Raman intratubular phosphate peak heights 49 to 70 au, and at the intertubular dentin 78 to 92). The formed carbonated apatite and calcium phosphate layer were resistant to citric acid application. Zinc compounds drastically increased tubule occlusion, decreased dentin permeability (up to 30%), and augmented mechanical properties at the intertubular dentin (90–130 GPa); it was maintained after acid challenging.

Conclusions

Zinc-containing pastes occluded dentinal tubules and improved dentin mechanical properties.

Clinical relevance

Using zinc as an active component to treat eroded dentin is encouraged.

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Title: Zinc and silica are active components to efficiently treat in vitro simulated eroded dentin
Authors: Raquel Osorio
Manuel Toledano-Osorio
Estrella Osorio
Fátima S. Aguilera
Sussette Padilla-Mondéjar
Manuel Toledano
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 8/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2372-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Zinc and silica are active components to efficiently treat in vitro simulated eroded dentin

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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