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01-03-2018 | Review

The effect of statins on periodontal treatment—a systematic review with meta-analyses and meta-regression

Authors: Francisco Wilker Mustafa Gomes Muniz, Keity Taminski, Juliano Cavagni, Roger Keller Celeste, Patrícia Weidlich, Cassiano Kuchenbecker Rösing

Published in: Clinical Oral Investigations | Issue 2/2018

Abstract

Objective

This study aimed to systematically review clinical trials about the effect of statins as adjunct to mechanical periodontal therapy, on probing pocket depth, clinical attachment level, and intrabony defects, in comparison to mechanical periodontal therapy alone or in association with placebo.

Material and methods

Three databases were searched for controlled clinical trials that used any locally delivered or systemically statin as a sole adjunctive therapy to mechanical periodontal treatment. Weighted mean differences between baseline and 6 months after periodontal treatment for clinical attachment level (CAL), probing pocket depth (PPD), and intrabony defect (IBD) were calculated. A high heterogeneity was detected. Therefore, a meta-regression adjusted for type of statin and year of publication was performed.

Results

Fifteen studies were included in the systematic review, and ten studies were included in the meta-analysis. In the meta-regression, the adjunct use of simvastatin, rosuvastatin, and atorvastatin additionally reduced PPD in comparison to mechanical periodontal therapy and a placebo gel (2.90 ± 0.35, 3.90 ± 0.77, 3.06 ± 0.71 mm, respectively; p < 0.05). Regarding the resolution of IBD, simvastatin and rosuvastatin significantly improved in comparison to control group (0.89 ± 0.35 and 1.93 ± 0.77 mm, respectively; p < 0.05). No statistically significant difference was found between the statins for both PPD and IBD (p < 0.05). Regarding CAL gain, simvastatin provided a statistically significant improvement as compared to the control group (2.02 ± 0.79 mm; p = 0.043).

Conclusions

The use of statins, used as sole adjuncts to mechanical periodontal treatment, improved the periodontal parameters. In the quantitative analyses, simvastatin was the only drug that showed additional benefits in all evaluated parameters.

Clinical relevance

Statins promote significantly clinical periodontal improvements when administered in association with non-surgical scaling and root planning (SRP), when compared to SRP alone or in association with a placebo.

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Title: The effect of statins on periodontal treatment—a systematic review with meta-analyses and meta-regression
Authors: Francisco Wilker Mustafa Gomes Muniz
Keity Taminski
Juliano Cavagni
Roger Keller Celeste
Patrícia Weidlich
Cassiano Kuchenbecker Rösing
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 2/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2354-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of statins on periodontal treatment—a systematic review with meta-analyses and meta-regression

Abstract

Objective

Material and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Material and methods

Results

Conclusions

Clinical relevance

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