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Clinical Oral Investigations

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01-03-2018 | Review

Can oral ADS activity or arginine levels be a caries risk indicator? A systematic review and meta-analysis

Authors: Mohammed Nadeem Ahmed Bijle, Cynthia Kar Yung Yiu, Manikandan Ekambaram

Published in: Clinical Oral Investigations | Issue 2/2018

Abstract

Objectives

The objective of this study was to evaluate the association between salivary and plaque arginine levels/ADS activities with dental caries.

Materials and methods

A systematic search was performed as per PRISMA statement using PubMed, Scopus, Cochrane Library, and Web of Science. Published studies that investigated adults and children (P) with caries-active status (E) and caries-free status (C), whereby arginine levels/ADS activity (O) was measured in saliva/plaque to analyze exposure-outcome association compared to the control group were deemed eligible for inclusion. Quality assessment was performed using combined Newcastle-Ottawa Scale and Modified RTI Item Bank scale. Meta-analysis was performed for effect size, precision estimation, and subgroup effects analysis.

Results

Of 233 records identified, seven (κ = 1.00) were included for qualitative synthesis (systematic review) and four for quantitative synthesis (meta-analysis). No specific bias could be identified in five studies assessed as per the Modified RTI Item Bank scale. Two studies received lower scores on the Newcastle Ottawa scale. Plaque ADS activity in adults (effect size = 0.93, p = 0.008), salivary ADS activity in adults and children (effect size = 0.85, p < 0.001), and salivary ADS activity in adults (effect size = 0.87, p < 0.001) identified a statistically significant effect size. Subgroup analysis demonstrated non-significant variance (Q value = 0.042, p = 0.838) between saliva and plaque ADS activities of adults.

Conclusions

The results of this review suggest the salivary and plaque ADS activities appear to be promising caries risk indicators for adults, while results remain inconclusive in children.

Clinical relevance

Measuring ADS activities (saliva or plaque) can be a potential caries risk indicator in adults. The protocol was registered on PROSPERO database: CRD42017060701.

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Title: Can oral ADS activity or arginine levels be a caries risk indicator? A systematic review and meta-analysis
Authors: Mohammed Nadeem Ahmed Bijle
Cynthia Kar Yung Yiu
Manikandan Ekambaram
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 2/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-017-2322-9

At a glance: The STEP trials

Springer Medicine

Can oral ADS activity or arginine levels be a caries risk indicator? A systematic review and meta-analysis

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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