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01-03-2018 | Original Article

Oral shedding of human herpesviruses in renal transplant recipients

Authors: Dmitry José de Santana Sarmento, Tânia Regina Tozetto-Mendoza, Laura Masami Sumita, Ligia Camara Pierroti, Débora Pallos, Rubens Caliento, Michelle Palmieri, Victor Adriano de Oliveira Martins, Marina Gallottini, Claudio Sergio Pannuti, Paulo Henrique Braz-Silva

Published in: Clinical Oral Investigations | Issue 2/2018

Abstract

Objective

To describe the shedding profile of human herpesviruses in the saliva of renal transplant recipients.

Methods

This is a prospective case-control study of 50 renal transplant recipients and control group of 50 individuals (non-transplanted and immunocompetent). Mouthwash samples were collected via oral rinse and then submitted to screening for the presence of eight types of herpesviruses by using multiplex PCR. Fisher’s exact, chi-square, and Student t tests were used for statistical analysis, and the significance level was set at 5%.

Results

The mean age of the study group was 49.42 ± 12.94 years, 28/50 (56%) were female, and the time elapsed after transplantation was 68.20 ± 67.19 months. Herpes simplex virus 1 (HSV-1) (P = 0.025) and Epstein-Barr virus (EBV) (P = 0.024) were, statistically, more excreted in the saliva of renal transplant recipients compared to control group. Gender (P = 1.00) and age (P = 0.563) did not influence the salivary shedding of herpesviruses in renal transplant recipients. Individuals who excreted varicella-zoster virus in saliva had a shorter mean time of transplantation (22:00 + 2.82 months) (P < 0.001).

Conclusion

Renal transplant recipients excreted herpesviruses more often than controls, especially HSV-1 and EBV, with salivary shedding of herpesviruses being more frequent in patients with recent kidney transplantation.

Clinical relevance

The present findings support other longitudinal studies evaluating the relationship between oral shedding of human herpesviruses and clinical presence of active infection and renal transplant failure.

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Title: Oral shedding of human herpesviruses in renal transplant recipients
Authors: Dmitry José de Santana Sarmento
Tânia Regina Tozetto-Mendoza
Laura Masami Sumita
Ligia Camara Pierroti
Débora Pallos
Rubens Caliento
Michelle Palmieri
Victor Adriano de Oliveira Martins
Marina Gallottini
Claudio Sergio Pannuti
Paulo Henrique Braz-Silva
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 2/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-017-2166-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Oral shedding of human herpesviruses in renal transplant recipients

Abstract

Objective

Methods

Results

Conclusion

Clinical relevance

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Clinical relevance

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