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01-01-2018 | Original Article

Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats

Authors: Leonardo Perez Faverani, Tárik Ocon Braga Polo, Gabriel Ramalho-Ferreira, Gustavo Antonio Correa Momesso, Jaqueline Suemi Hassumi, Ana Cláudia Rossi, Alexandre Rodrigues Freire, Felippe Bevilacqua Prado, Eloá Rodrigues Luvizuto, Reinhard Gruber, Roberta Okamoto

Published in: Clinical Oral Investigations | Issue 1/2018

Abstract

Objectives

Alendronate and raloxifene, a bisphosphonate and a selective estrogen modulator, respectively, are established osteoporosis therapies. Current evidence suggests that simultaneous application of osteoporosis therapies modulates osseointegration. However, alendronate shows inconsistent findings and raloxifene has not been studied comprehensively. This study aimed to evaluate the bone dynamics and molecular and microstructural features at the peri-implant bone interface in osteoporotic rats.

Materials and methods

Thirty female rats underwent ovariectomy and were fed a diet low in calcium and phosphate and treated with alendronate or raloxifene for 30 days or underwent fictional ovariectomy surgery (SHAM) prior to implant insertion in the tibia; osteoporosis therapies continued thereafter. After 42 days, peri-implant bone was evaluated by histometric and micro-CT analysis. Fluorochrome incorporation and gene expression was determined to evaluate bone turnover.

Results

We report here that alendronate had no impact on bone-to-implant contacts and the mineral apposition rate. The RANKL/OPG ratio and local bone volume, however, were increased compared to the untreated osteoporotic rats. Even though signaling to bone resorption activity through RANKL production was observed in the alendronate group, the blockade of bone resorption activity that occurs in decorrence to alendronate activity took place and resulted in an increase in bone volume. Raloxifene significantly increased osseointegration in osteoporotic rats, as indicated by bone-to-implant contacts, mineral apposition, and local bone volume. Raloxifene, however, had no considerable impact on the RANKL/OPG ratio compared to untreated osteoporotic rats. As expected, the SH group showed higher bone-to-implant contacts and mineral apposition rates than the untreated osteoporotic rats.

Conclusions

These findings suggest that raloxifene but not alendronate can compensate for the impaired osseointegration in osteoporotic rats.

Clinical relevance

Regarding the superiority of raloxifene observed in the improvement of bone dynamics response, this statement suggests that raloxifene could be a good option for osteoporosis patients in oral rehabilitation procedures.

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Title: Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats
Authors: Leonardo Perez Faverani
Tárik Ocon Braga Polo
Gabriel Ramalho-Ferreira
Gustavo Antonio Correa Momesso
Jaqueline Suemi Hassumi
Ana Cláudia Rossi
Alexandre Rodrigues Freire
Felippe Bevilacqua Prado
Eloá Rodrigues Luvizuto
Reinhard Gruber
Roberta Okamoto
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 1/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-017-2106-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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