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Clinical Oral Investigations
Published in: Clinical Oral Investigations 6/2017

Open Access 01-07-2017 | Original Article

Growth and prevalence of feeding difficulties in children with Robin sequence: a retrospective cohort study

Authors: Emma C. Paes, Iris A.C. de Vries, Wouter M. Penris, Karlijn H. Hanny, Selma W. Lavrijsen, Elselien K. van Leerdam, Maaike M. Rademaker, Esther S. Veldhoen, Rene M.J.C. Eijkemans, Moshe Kon, Corstiaan C. Breugem

Published in: Clinical Oral Investigations | Issue 6/2017

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Abstract

Objectives

In addition to breathing problems, patients with Robin sequence (RS) often encounter feeding difficulties (FD). Data regarding the occurrence of FD and possible influencing factors are scarce. The study aim was to elucidate these factors to improve treatment strategies.

Material and methods

A retrospective comparative cohort study was conducted, consisting of 69 infants diagnosed with both RS and a cleft palate and 64 isolated cleft palate only (iCPO) infants. Data regarding FD, growth, and airway intervention were collected during the first 2 years of life. A systematic review of the literature was conducted to identify reported FD in RS patients.

Results

RS patients had more FD (91 %) than iCPO patients (72 %; p = 0.004). Also, nasogastric (NG)-tube feeding was necessary more frequently and for a longer period (both p < 0.001). Growth was lower in RS than iCPO infants (p = 0.008) and was not affected by the kind of airway management (conservative/surgical; p = 0.178), cleft palate grade (p = 0.308), or associated disorders (p = 0.785). By contrast, surgical intervention subtype did significantly affect growth. Mean reported FD for RS in the literature is 80 % (range = 47–100 %), and 55 % (range = 11–100 %) of infants need NG-tube feeding.

Conclusions

FD is present in a large proportion of infants with RS, which indicates the need for early recognition and proper treatment to ensure optimal growth. Growth during the first 2 years of life is significantly lower in RS patients than iCPO patients, which indicates the need for careful attention and long-term follow-up.

Clinical relevance

This study indicates the need for early recognition and proper treatment of FD in RS to ensure optimal growth. In addition, growth needs careful attention and long-term follow-up.
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Metadata
Title
Growth and prevalence of feeding difficulties in children with Robin sequence: a retrospective cohort study
Authors
Emma C. Paes
Iris A.C. de Vries
Wouter M. Penris
Karlijn H. Hanny
Selma W. Lavrijsen
Elselien K. van Leerdam
Maaike M. Rademaker
Esther S. Veldhoen
Rene M.J.C. Eijkemans
Moshe Kon
Corstiaan C. Breugem
Publication date
01-07-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 6/2017
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-016-1996-8

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