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Published in:

01-09-2017 | Original Article

Opiorphin levels in fluids of burning mouth syndrome patients: a case-control study

Authors: Yves Boucher, Adeline Braud, Evelyne Dufour, Scarlette Agbo-Godeau, Vanessa Baaroun, Vianney Descroix, Marie-Thérèse Guinnepain, Marie-Noëlle Ungeheuer, Catherine Ottone, Catherine Rougeot

Published in: Clinical Oral Investigations | Issue 7/2017

Abstract

Objectives

Idiopathic Burning mouth syndrome (iBMS) is a poorly understood affection characterized by persistent pain in the oral cavity without any clinical or biological abnormality. Opiorphin is a natural inhibitor of enkephalin-inactivating ectopeptidases, mainly produced by salivary glands, that has demonstrated analgesic properties. The objective of the present case-control study was to test the hypothesis of a decrease in opiorphin levels in iBMS patients.

Materials and methods

Twenty-one iBMS patients and 21 matched controls subjects were included between 2011 and 2013. Submandibular and sublingual salivary, blood, and urinary opiorphin levels of iBMS patients were compared to controls.

Results

Results are expressed as mean values ± SD and compared using the Wilcoxon Signed Rank test. Correlations were analyzed with Spearman coefficient. The level of significance was fixed at p < 0.05. Opiorphin levels in iBMS and controls were respectively (in ng/ml) in basal saliva: 37.8 ± 42.5 and 67.6 ± 188.9 (p = NS); stimulated saliva: 28.8 ± 25.3 and 31.1 ± 29.1 (p = NS); blood: 4.6 ± 5.4 and 1.9 ± 1.4 (p < 0.05); and urines: 68.5 ± 259.8 and 8.9 ± 6.2 (p = NS).

Clinical relevance

In conclusion, the lack of significative difference in salivary opiorphin levels between iBMS and controls does not favor a direct local role for opiorphin in the etiopathogeny of iBMS. However, higher blood opiorphin levels may reflect a systemic dysregulation in iBMS.

Trial registration

NCT02686359 https://clinicaltrials.gov/ct2/show/NCT02686359

Available only for authorised users

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Title: Opiorphin levels in fluids of burning mouth syndrome patients: a case-control study
Authors: Yves Boucher
Adeline Braud
Evelyne Dufour
Scarlette Agbo-Godeau
Vanessa Baaroun
Vianney Descroix
Marie-Thérèse Guinnepain
Marie-Noëlle Ungeheuer
Catherine Ottone
Catherine Rougeot
Publication date: 01-09-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 7/2017
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-016-1991-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Opiorphin levels in fluids of burning mouth syndrome patients: a case-control study

Abstract

Objectives

Materials and methods

Results

Clinical relevance

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Clinical relevance

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