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Published in: Clinical Oral Investigations 5/2017

Open Access 01-06-2017 | Original Article

Long-term mid-facial growth of patients with a unilateral complete cleft of lip, alveolus and palate treated by two-stage palatoplasty: cephalometric analysis

Authors: I. F. P. M. Kappen, G. K. P. Bittermann, R. M. Schouten, D. Bittermann, E. Etty, R. Koole, M. Kon, A. B. Mink van der Molen, C. C. Breugem

Published in: Clinical Oral Investigations | Issue 5/2017

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Abstract

Objectives

The aim of this study is to evaluate long-term facial growth in adults previously treated for an isolated unilateral complete cleft lip, alveolus and palate by two-stage palatoplasty.

Materials and methods

Unilateral cleft lip and palate (UCLP) patients of 17 years and older treated by two-stage palatoplasty were invited for long-term follow-up. During follow-up, lateral cephalograms were obtained (n = 52). Medical history was acquired from their medical files. Outcome was compared to previously published normal values and the Eurocleft study.

Results

Soft and hard palate closure were performed at the age of 8 (SD 5.9) months and 3 (SD 2.2) years, respectively. The mean maxillary and mandibular angle (SNA, SNB) were 74.9° (SD 4.2) and 75.8° (SD 3.8). Maxillary and maxillomandibular relationships (SNA, ANB) were comparable to all Eurocleft Centres, except for Centre D. We observed a significantly steeper upper interincisor angle compared to the Eurocleft Centres.

Conclusions

This study describes the long-term craniofacial morphology in adults treated for a UCLP with hard palate closure at a mean age of 3 years. The mean maxillary angle SNA and mandibular angle SNPg were comparable to previous studies both applying early and delayed hard palate closure. The observed upper incisor proclination is likely caused by orthodontic overcorrection in response to the unfavourable jaw relationships. No clear growth benefit of this protocol could be demonstrated.

Clinical relevance

The present study shows the long-term craniofacial morphology of UCLP adults after the Utrecht treatment protocol which includes two-stage palate closure.
Literature
1.
go back to reference Semb G (1991) A study of facial growth in patients with unilateral cleft lip and palate treated by the Oslo CLP team. Cleft Palate-Cran J 28:1–21CrossRef Semb G (1991) A study of facial growth in patients with unilateral cleft lip and palate treated by the Oslo CLP team. Cleft Palate-Cran J 28:1–21CrossRef
2.
go back to reference Friede H, Lilja J, Lohmander A (2012) Long-term, longitudinal follow-up of individuals with UCLP after the Gothenburg primary early veloplasty and delayed hard palate closure protocol: maxillofacial growth outcome. Cleft Palate-Cran J 49:649–656. doi:10.1597/10-252 CrossRef Friede H, Lilja J, Lohmander A (2012) Long-term, longitudinal follow-up of individuals with UCLP after the Gothenburg primary early veloplasty and delayed hard palate closure protocol: maxillofacial growth outcome. Cleft Palate-Cran J 49:649–656. doi:10.​1597/​10-252 CrossRef
3.
go back to reference Semb G, Shaw WC (2013) Facial growth related to surgical methods. In: Berkowitz S (ed) Cleft lip palate. Springer Berlin Heidelberg, Heidelberg, Berlin, pp. 325–343CrossRef Semb G, Shaw WC (2013) Facial growth related to surgical methods. In: Berkowitz S (ed) Cleft lip palate. Springer Berlin Heidelberg, Heidelberg, Berlin, pp. 325–343CrossRef
4.
go back to reference Liao YF, Mars M (2006) Hard palate repair timing and facial morphology in unilateral cleft lip and palate: before versus after pubertal peak velocity age. Cleft Palate-Cran J 43:259–265. doi:10.1597/04-196R.1 CrossRef Liao YF, Mars M (2006) Hard palate repair timing and facial morphology in unilateral cleft lip and palate: before versus after pubertal peak velocity age. Cleft Palate-Cran J 43:259–265. doi:10.​1597/​04-196R.​1 CrossRef
6.
go back to reference Berkowitz S (2013) Choosing the best time for palatal surgery. In: Berkowitz S (ed) Cleft lip palate. Springer Berlin Heidelberg, Heidelberg, Berlin, pp. 389–409CrossRef Berkowitz S (2013) Choosing the best time for palatal surgery. In: Berkowitz S (ed) Cleft lip palate. Springer Berlin Heidelberg, Heidelberg, Berlin, pp. 389–409CrossRef
7.
go back to reference Schweckendiek H (1951) The problem of early and late surgery in congenital fissure of the of the lips and palate. Z Laryngol Rhinol Otol 30:51–56PubMed Schweckendiek H (1951) The problem of early and late surgery in congenital fissure of the of the lips and palate. Z Laryngol Rhinol Otol 30:51–56PubMed
8.
go back to reference Lilja J, Mars M, Elander A, Enocson L, Hagberg C, Worell E, Batra P, Friede H (2006) Analysis of dental arch relationships in Swedish unilateral cleft lip and palate subjects: 20-year longitudinal consecutive series treated with delayed hard palate closure. Cleft Palate-Cran J 43:606–611CrossRef Lilja J, Mars M, Elander A, Enocson L, Hagberg C, Worell E, Batra P, Friede H (2006) Analysis of dental arch relationships in Swedish unilateral cleft lip and palate subjects: 20-year longitudinal consecutive series treated with delayed hard palate closure. Cleft Palate-Cran J 43:606–611CrossRef
9.
go back to reference Liao Y, Cole T, Mars M (2006) Hard palate repair timing and facial growth in unilateral cleft lip and palate: a systematic review. Cleft Palate Craniofac J 43:563–570CrossRefPubMed Liao Y, Cole T, Mars M (2006) Hard palate repair timing and facial growth in unilateral cleft lip and palate: a systematic review. Cleft Palate Craniofac J 43:563–570CrossRefPubMed
10.
11.
go back to reference Brattström V, Mølsted K, Prahl-Andersen B, Semb G, Shaw WC (2005) The Eurocleft study: intercenter study of treatment outcome in patients with complete cleft lip and palate. Part 2: craniofacial form and nasolabial appearance. Cleft Palate-Cran J 42:69–77. doi:10.1597/02-119.2.1 CrossRef Brattström V, Mølsted K, Prahl-Andersen B, Semb G, Shaw WC (2005) The Eurocleft study: intercenter study of treatment outcome in patients with complete cleft lip and palate. Part 2: craniofacial form and nasolabial appearance. Cleft Palate-Cran J 42:69–77. doi:10.​1597/​02-119.​2.​1 CrossRef
12.
go back to reference Nollet PJPM, Katsaros C, Huyskens RWF, Borstlap WA, Bronhorst EM, Kuijpers-Jagtman AM (2008) Cephalometric evaluation of long-term craniofacial development in unilateral cleft lip and palate patients treated with delayed hard palate closure. Int J Oral Max Surg 37:123–130. doi:10.1016/j.ijom.2007.09.168 CrossRef Nollet PJPM, Katsaros C, Huyskens RWF, Borstlap WA, Bronhorst EM, Kuijpers-Jagtman AM (2008) Cephalometric evaluation of long-term craniofacial development in unilateral cleft lip and palate patients treated with delayed hard palate closure. Int J Oral Max Surg 37:123–130. doi:10.​1016/​j.​ijom.​2007.​09.​168 CrossRef
13.
go back to reference Thilander B, Persson M, Adolfsson U (2005) Roentgen-cephalometric standards for a Swedish population. A longitudinal study between the ages of 5 and 31 years. Eur J Orthod 27:370–389. doi:10.1093/ejo/cji033 CrossRefPubMed Thilander B, Persson M, Adolfsson U (2005) Roentgen-cephalometric standards for a Swedish population. A longitudinal study between the ages of 5 and 31 years. Eur J Orthod 27:370–389. doi:10.​1093/​ejo/​cji033 CrossRefPubMed
14.
go back to reference Simes R (1986) An improved Bonferroni procedure for multiple tests of significance. Biometrika 73:751–754CrossRef Simes R (1986) An improved Bonferroni procedure for multiple tests of significance. Biometrika 73:751–754CrossRef
16.
go back to reference Bland J, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 8476:307–310CrossRef Bland J, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 8476:307–310CrossRef
17.
go back to reference Friede H (1998) Growth sites and growth mechanisms at risk in cleft lip and palate. Acta Odontol Scand 56:346–351CrossRefPubMed Friede H (1998) Growth sites and growth mechanisms at risk in cleft lip and palate. Acta Odontol Scand 56:346–351CrossRefPubMed
18.
go back to reference Friede H, Johanson B (1974) A follow-up study of cleft children treated with primary bone grafting. 1. Orthodontic aspects. Scand J Plast Reconstr Surg 8:88–103CrossRefPubMed Friede H, Johanson B (1974) A follow-up study of cleft children treated with primary bone grafting. 1. Orthodontic aspects. Scand J Plast Reconstr Surg 8:88–103CrossRefPubMed
19.
go back to reference Ross (1987) Treatment variables affecting growth in unilateral cleft lip and palate. Part 5: timing of palate repair. Cleft Palate J 24:54–63 Ross (1987) Treatment variables affecting growth in unilateral cleft lip and palate. Part 5: timing of palate repair. Cleft Palate J 24:54–63
20.
go back to reference Smahel Z, Müllerova Z, Nejedly A, Horak I (1998) Changes in craniofacial development due to modifications of the treatment of unilateral cleft lip and palate. Cleft Palate-Cran J 35:240–247CrossRef Smahel Z, Müllerova Z, Nejedly A, Horak I (1998) Changes in craniofacial development due to modifications of the treatment of unilateral cleft lip and palate. Cleft Palate-Cran J 35:240–247CrossRef
21.
go back to reference Friede H (2007) Maxillary growth controversies after two-stage palatal repair with delayed hard palate closure in unilateral cleft lip and palate patients: perspectives from literature and personal experience. Cleft Palate-Cran J 44:129–136CrossRef Friede H (2007) Maxillary growth controversies after two-stage palatal repair with delayed hard palate closure in unilateral cleft lip and palate patients: perspectives from literature and personal experience. Cleft Palate-Cran J 44:129–136CrossRef
24.
go back to reference Gaggl A, Feichtinger M, Schultes G, Santler G, Pichlmaier M, Mossböck R, Kärcher H (2003) Cephalometric and occlusal outcome in adults with unilateral cleft lip, palate, and alveolus after two different surgical techniques. Cleft Palate Craniofac J 40:249–255CrossRefPubMed Gaggl A, Feichtinger M, Schultes G, Santler G, Pichlmaier M, Mossböck R, Kärcher H (2003) Cephalometric and occlusal outcome in adults with unilateral cleft lip, palate, and alveolus after two different surgical techniques. Cleft Palate Craniofac J 40:249–255CrossRefPubMed
26.
go back to reference Friede H (1978) The vomero-premaxillary suture—a neglected growth site in mid-facial development of unilateral cleft lip and palate patients. Cleft Palate J 15:398–404PubMed Friede H (1978) The vomero-premaxillary suture—a neglected growth site in mid-facial development of unilateral cleft lip and palate patients. Cleft Palate J 15:398–404PubMed
27.
go back to reference Farronato G, Kairyte L, Giannini L, Galbiati G, Maspero C (2014) How various surgical protocols of the unilateral cleft lip and palate influence the facial growth and possible orthodontic problems? Which is the best timing of lip, palate and alveolus repair? Literature review. Stomatologija 16:53–60PubMed Farronato G, Kairyte L, Giannini L, Galbiati G, Maspero C (2014) How various surgical protocols of the unilateral cleft lip and palate influence the facial growth and possible orthodontic problems? Which is the best timing of lip, palate and alveolus repair? Literature review. Stomatologija 16:53–60PubMed
28.
go back to reference Bardach J, Morris H, Olin W (1984) Late results of primary veloplasty: the Marburg project. Plast Reconstr Surg 73:207–215CrossRefPubMed Bardach J, Morris H, Olin W (1984) Late results of primary veloplasty: the Marburg project. Plast Reconstr Surg 73:207–215CrossRefPubMed
29.
go back to reference Good PM, Mulliken JB, Padwa BL (2007) Frequency of Le Fort I osteotomy after repaired cleft lip and palate or cleft palate. Cleft Palate-Cran J 44:396–401CrossRef Good PM, Mulliken JB, Padwa BL (2007) Frequency of Le Fort I osteotomy after repaired cleft lip and palate or cleft palate. Cleft Palate-Cran J 44:396–401CrossRef
31.
go back to reference Shaw W, Semb G, Lohmander (2015) Clinical outcomes research and evidence-based practice. In: Losee J, Kirschner R (eds) Comprehensive cleft care, 3rd edn. CRC Press, Boca Raton [In press] Shaw W, Semb G, Lohmander (2015) Clinical outcomes research and evidence-based practice. In: Losee J, Kirschner R (eds) Comprehensive cleft care, 3rd edn. CRC Press, Boca Raton [In press]
32.
go back to reference Liao Y-F, Cole TJ, Mars M (2006) Hard palate repair timing and facial growth in unilateral cleft lip and palate: a longitudinal study. Cleft Palate Craniofac J 43:547–556. doi:10.1597/05-119 CrossRefPubMed Liao Y-F, Cole TJ, Mars M (2006) Hard palate repair timing and facial growth in unilateral cleft lip and palate: a longitudinal study. Cleft Palate Craniofac J 43:547–556. doi:10.​1597/​05-119 CrossRefPubMed
33.
go back to reference Trenouth MJ, Davies PJH, Johnson JS (1985) A statistical comparison of three sets of normative data from which to derive standards for craniofacial measurement. Eur J Orthod 7(3):193–200CrossRefPubMed Trenouth MJ, Davies PJH, Johnson JS (1985) A statistical comparison of three sets of normative data from which to derive standards for craniofacial measurement. Eur J Orthod 7(3):193–200CrossRefPubMed
Metadata
Title
Long-term mid-facial growth of patients with a unilateral complete cleft of lip, alveolus and palate treated by two-stage palatoplasty: cephalometric analysis
Authors
I. F. P. M. Kappen
G. K. P. Bittermann
R. M. Schouten
D. Bittermann
E. Etty
R. Koole
M. Kon
A. B. Mink van der Molen
C. C. Breugem
Publication date
01-06-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 5/2017
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-016-1949-2

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