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Clinical Oral Investigations
Published in: Clinical Oral Investigations 4/2017

01-05-2017 | Original Article

Expansion of the peri-implant attached gingiva with a three-dimensional collagen matrix in head and neck cancer patients—results from a prospective clinical and histological study

Authors: Jonas Lorenz, Maximilian Blume, Mike Barbeck, Anna Teiler, C. James Kirkpatrick, Robert A. Sader, Shahram Ghanaati

Published in: Clinical Oral Investigations | Issue 4/2017

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Abstract

Objectives

Attached peri-implant gingiva has proven to have an influence on the long-term stability of dental implants. In patients with head and neck cancer, a functional peri-implant gingiva is even more of critical importance. The aim of the presented prospective study was to investigate a three-dimensional xenogeneic collagen matrix for augmentation around dental implants in patients with former head and neck cancer.

Material and methods

Eight patients presenting with insufficient peri-implant gingiva underwent vestibuloplasty on 51 implants using a xenogeneic collagen matrix. The clinical performance and the shrinking tendency of the matrix were analyzed in a cohort study. Furthermore, eight biopsies from the augmented regions were examined histologically to determine the biomaterial-related tissue reaction.

Results

Initially after vestibuloplasty, a mean width of attached gingiva of 4.4 ± 0.94 mm could be achieved. At clinical follow up investigation 6 months after vestibuloplasty, a mean width of 3.9 ± 0.65 mm attached peri-implant gingiva with a mean shrinking tendency of 14 % could be detected. Histological analysis of the biopsies revealed a well integrated collagen22 matrix covered with epithelium. Within the compact layer, mononuclear cells were observed only, while the spongious layer was infiltrated with a cell-rich connective tissue.

Conclusion

Within its limits, the presented study revealed that the investigated collagen matrix is suitable to enlarge the peri-implant attached gingiva in head and neck cancer patients without adverse reactions or a multinucleated giant cell-triggered tissue reaction.

Clinical relevance

The application of the investigated three-dimensional collagen matrix in vestibuloplasty achieved a sufficient amount of peri-implant attached gingiva in head and neck cancer patients. The favorable tissue reaction and the low shrinking tendency make the collagen matrix a promising alternative to autologous tissue grafts.
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Metadata
Title
Expansion of the peri-implant attached gingiva with a three-dimensional collagen matrix in head and neck cancer patients—results from a prospective clinical and histological study
Authors
Jonas Lorenz
Maximilian Blume
Mike Barbeck
Anna Teiler
C. James Kirkpatrick
Robert A. Sader
Shahram Ghanaati
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 4/2017
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-016-1868-2

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