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Clinical Oral Investigations

Published in:

01-04-2017 | Original Article

Polymorphisms of interleukin-1β and MUC7 genes in burning mouth syndrome

Authors: Moon-Jong Kim, Jihoon Kim, Ji-Youn Chang, Yoon-Young Kim, Hong-Seop Kho

Published in: Clinical Oral Investigations | Issue 3/2017

Abstract

Objective

The objectives of the present study are to compare polymorphisms of the IL-1β and MUC7 genes between patients with burning mouth syndrome (BMS) and controls and to investigate relationships between these polymorphisms and clinical characteristics in BMS patients.

Materials and methods

Forty female BMS patients and 40 gender- and age-matched controls were included. Genomic DNA was extracted from saliva samples. Single-nucleotide polymorphisms of IL-1β −511 and +3954 and variation in number of tandem repeat (VNTR) polymorphism of MUC7 were analyzed. Relationships between genotypic polymorphism data and clinical characteristics in BMS patients were also analyzed.

Results

There were no significant differences in the genotypes of IL-1β −511 and +3954 and of MUC7 between the groups. There were no significant differences in symptom duration and intensity of BMS patients according to their IL-1β and MUC7 genotypes. The T allele of IL-1β −511 showed associations with psychometry results in BMS patients: paranoid ideation (P = 0.014), Global Severity Index (P = 0.025), and Positive Symptom Total (P = 0.008).

Conclusions

The genotypic polymorphisms of IL-1β −511 and +3954, and of MUC7 VNTR, had no direct associations with the development of BMS. However, the T allele of IL-1β −511 may increase the risk of BMS by increasing psychological asthenia.

Clinical relevance

The genotypic polymorphisms of IL-1β −511 may increase the risk for the development of BMS by increasing psychological asthenia.

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Title: Polymorphisms of interleukin-1β and MUC7 genes in burning mouth syndrome
Authors: Moon-Jong Kim
Jihoon Kim
Ji-Youn Chang
Yoon-Young Kim
Hong-Seop Kho
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 3/2017
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-016-1866-4

At a glance: The STEP trials

Springer Medicine

Polymorphisms of interleukin-1β and MUC7 genes in burning mouth syndrome

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

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