Skip to main content
Top
Published in: Clinical Oral Investigations 2/2015

01-03-2015 | Original Article

Clinical results of implant placement in resorbed ridges using simultaneous guided bone regeneration: a multicenter case series

Authors: Ioannis Konstantinidis, Tarun Kumar, Udatta Kher, Panagiotis D. Stanitsas, James E. Hinrichs, Georgios A. Kotsakis

Published in: Clinical Oral Investigations | Issue 2/2015

Login to get access

Abstract

Objectives

The purpose of this case series was to evaluate the new bone formation following guided bone regeneration (GBR) with a calcium phosphosilicate (CPS), alloplastic bone putty at peri-implant dehiscence defects and to assess survival rate of implants placed in the augmented sites after 12 months of function.

Materials and methods

Implants were placed in patients exhibiting Seibert class I ridge defects resulting in peri-implant dehiscence defects. The defects were treated following GBR principles with the use of a CPS alloplastic bone graft putty in combination either with a collagen membrane or a titanium mesh. The height of each bony dehiscence was clinically measured at the time of implant placement and again during second-stage surgery. The percentage of complete defect coverage, frequency of adverse events, and risk factors for residual defect were determined.

Results

Thirty-six implants were placed in 26 patients. Twenty-seven of the 36 sites employed a collagen membrane in conjunction with the CPS while the remaining nine sites utilized a titanium membrane. Mean gain in bone height was 3.23 ± 2.04 mm, with 75 % of the peri-implant defects achieving complete regeneration. A negative correlation was identified between patient age and complete coverage of the peri-implant defect (p = 0.026). The implant survival rate at 12 months was 97.22 %.

Conclusion

Use of CPS bone putty during delayed implant placement at peri-implant dehiscence sites either in combination with a collagen membrane or a titanium mesh results in predictable defect coverage.

Clinical relevance

The handling characteristics of CPS putty may simplify GBR protocol. Implants placed in conjunction with GBR have a very good survival rate after 1 year of follow-up.
Literature
1.
go back to reference Schropp L, Wenzel A, Kostopoulos L, Karring T (2003) Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 23:313–323PubMed Schropp L, Wenzel A, Kostopoulos L, Karring T (2003) Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 23:313–323PubMed
2.
go back to reference Covani U, Ricci M, Bozzolo G, Mangano F, Zini A, Barone A (2011) Analysis of the pattern of the alveolar ridge remodelling following single tooth extraction. Clin Oral Implants Res 22:820–825CrossRefPubMed Covani U, Ricci M, Bozzolo G, Mangano F, Zini A, Barone A (2011) Analysis of the pattern of the alveolar ridge remodelling following single tooth extraction. Clin Oral Implants Res 22:820–825CrossRefPubMed
3.
go back to reference Dahlin C, Simion M, Hatano N (2010) Long-term follow-up on soft and hard tissue levels following guided bone regeneration treatment in combination with a xenogeneic filling material: a 5-year prospective clinical study. Clin Implant Dent Relat Res 12:263–270CrossRefPubMed Dahlin C, Simion M, Hatano N (2010) Long-term follow-up on soft and hard tissue levels following guided bone regeneration treatment in combination with a xenogeneic filling material: a 5-year prospective clinical study. Clin Implant Dent Relat Res 12:263–270CrossRefPubMed
4.
go back to reference Benić GI, Jung RE, Siegenthaler DW, Hämmerle CH (2009) Clinical and radiographic comparison of implants in regenerated or native bone: 5-year results. Clin Oral Implants Res 20:507–513CrossRefPubMed Benić GI, Jung RE, Siegenthaler DW, Hämmerle CH (2009) Clinical and radiographic comparison of implants in regenerated or native bone: 5-year results. Clin Oral Implants Res 20:507–513CrossRefPubMed
5.
go back to reference Zitzmann NU, Schärer P, Marinello CP (2001) Long-term results of implants treated with guided bone regeneration: a 5-year prospective study. Int J Oral Maxillofac Implants 16:355–366PubMed Zitzmann NU, Schärer P, Marinello CP (2001) Long-term results of implants treated with guided bone regeneration: a 5-year prospective study. Int J Oral Maxillofac Implants 16:355–366PubMed
6.
go back to reference Mayfield L, Skoglund A, Nobréus N, Attström R (1998) Clinical and radiographic evaluation, following delivery of fixed reconstructions, at GBR treated titanium fixtures. Clin Oral Implants Res 9:292–302CrossRefPubMed Mayfield L, Skoglund A, Nobréus N, Attström R (1998) Clinical and radiographic evaluation, following delivery of fixed reconstructions, at GBR treated titanium fixtures. Clin Oral Implants Res 9:292–302CrossRefPubMed
7.
go back to reference Hellem S, Astrand P, Stenström B, Engquist B, Bengtsson M, Dahlgren S (2003) Implant treatment in combination with lateral augmentation of the alveolar process: a 3-year prospective study. Clin Implant Dent Relat Res 5:233–240CrossRefPubMed Hellem S, Astrand P, Stenström B, Engquist B, Bengtsson M, Dahlgren S (2003) Implant treatment in combination with lateral augmentation of the alveolar process: a 3-year prospective study. Clin Implant Dent Relat Res 5:233–240CrossRefPubMed
8.
go back to reference Chiapasco M, Zaniboni M (2009) Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: a systematic review. Clin Oral Implants Res 4:113–123CrossRef Chiapasco M, Zaniboni M (2009) Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: a systematic review. Clin Oral Implants Res 4:113–123CrossRef
9.
go back to reference Bender SA, Rogalski JB, Mills MP, Arnold RM, Cochran DL, Mellonig JT (2005) Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects. J Periodontol 76:768–777CrossRefPubMed Bender SA, Rogalski JB, Mills MP, Arnold RM, Cochran DL, Mellonig JT (2005) Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects. J Periodontol 76:768–777CrossRefPubMed
10.
go back to reference Babbush CA (2003) Histologic evaluation of human biopsies after dental augmentation with a demineralized bone matrix putty. Implant Dent 12:325–332CrossRefPubMed Babbush CA (2003) Histologic evaluation of human biopsies after dental augmentation with a demineralized bone matrix putty. Implant Dent 12:325–332CrossRefPubMed
11.
go back to reference Butz F, Bächle M, Ofer M, Marquardt K, Kohal RJ (2011) Sinus augmentation with bovine hydroxyapatite/synthetic peptide in a sodium hyaluronate carrier (PepGen P-15 Putty): a clinical investigation of different healing times. Int J Oral Maxillofac Implants 26:1317–1323PubMed Butz F, Bächle M, Ofer M, Marquardt K, Kohal RJ (2011) Sinus augmentation with bovine hydroxyapatite/synthetic peptide in a sodium hyaluronate carrier (PepGen P-15 Putty): a clinical investigation of different healing times. Int J Oral Maxillofac Implants 26:1317–1323PubMed
12.
go back to reference Wang Z, Lu B, Chen L, Chang J (2011) Evaluation of an osteostimulative putty in the sheep spine. J Mater Sci Mater Med 22:185–191CrossRefPubMed Wang Z, Lu B, Chen L, Chang J (2011) Evaluation of an osteostimulative putty in the sheep spine. J Mater Sci Mater Med 22:185–191CrossRefPubMed
13.
go back to reference Kotsakis GA, Joachim F, Saroff SA, Mahesh L, Prasad H, Rohrer M (2014) Histomorphometric evaluation of a calcium-phosphosilicate bone substitute in extraction sockets. Int J Periodontics Restorative Dent 34:233–239CrossRefPubMed Kotsakis GA, Joachim F, Saroff SA, Mahesh L, Prasad H, Rohrer M (2014) Histomorphometric evaluation of a calcium-phosphosilicate bone substitute in extraction sockets. Int J Periodontics Restorative Dent 34:233–239CrossRefPubMed
14.
go back to reference Kotsakis GA, Salama M, Chrepa V, Hinrichs J, Gaillard P (2014) A randomized, blinded, controlled clinical study of particulate anorganic bovine bone mineral and calcium phosphosilicate putty bone substitutes for alveolar ridge preservation. Int J Oral Maxillofac Implants 29:141–151CrossRefPubMed Kotsakis GA, Salama M, Chrepa V, Hinrichs J, Gaillard P (2014) A randomized, blinded, controlled clinical study of particulate anorganic bovine bone mineral and calcium phosphosilicate putty bone substitutes for alveolar ridge preservation. Int J Oral Maxillofac Implants 29:141–151CrossRefPubMed
15.
go back to reference Hench LL, Polakjm (2008) A genetic basis for design of biomaterials for in situ regeneration. Key Eng Mater 377:151–166CrossRef Hench LL, Polakjm (2008) A genetic basis for design of biomaterials for in situ regeneration. Key Eng Mater 377:151–166CrossRef
16.
go back to reference Xynos ID, Edgar AI, Buttery LDK, Hench LL, Polak JM (2001) Gene-expression profiling of human osteoblasts following treatment with the ionic products of bioglass 45S5 dissolution. J Biomed Mater Res 55:151–157CrossRefPubMed Xynos ID, Edgar AI, Buttery LDK, Hench LL, Polak JM (2001) Gene-expression profiling of human osteoblasts following treatment with the ionic products of bioglass 45S5 dissolution. J Biomed Mater Res 55:151–157CrossRefPubMed
17.
go back to reference Seibert JS (1983) Reconstruction of deformed, partially edentulous ridges, using full thickness onlay grafts. Part II. Prosthetic/periodontal interrelationships. Compend Contin Educ Dent 4:549–562PubMed Seibert JS (1983) Reconstruction of deformed, partially edentulous ridges, using full thickness onlay grafts. Part II. Prosthetic/periodontal interrelationships. Compend Contin Educ Dent 4:549–562PubMed
18.
go back to reference Karoussis IK, Brägger U, Salvi GE, Bürgin W, Lang NP (2004) Effect of implant design on survival and success rates of titanium oral implants: a 10-year prospective cohort study of the ITI Dental Implant System. Clin Oral Implants Res 15:8–17CrossRefPubMed Karoussis IK, Brägger U, Salvi GE, Bürgin W, Lang NP (2004) Effect of implant design on survival and success rates of titanium oral implants: a 10-year prospective cohort study of the ITI Dental Implant System. Clin Oral Implants Res 15:8–17CrossRefPubMed
19.
go back to reference Weber HP, Lang NP (1990) Tissue integration of non-submerged implants. 1-year results of a prospective study with 100 ITI hollow-cylinder and hollow-screw implants. Clin Oral Implants Res 1:33–40CrossRefPubMed Weber HP, Lang NP (1990) Tissue integration of non-submerged implants. 1-year results of a prospective study with 100 ITI hollow-cylinder and hollow-screw implants. Clin Oral Implants Res 1:33–40CrossRefPubMed
20.
go back to reference Artzi Z, Nemcovsky CE, Tal H, Weinberg E, Weinreb M, Prasad H, Rohrer MD, Kozlovsky A (2010) Simultaneous versus two-stage implant placement and guided bone regeneration in the canine: histomorphometry at 8 and 16 months. J Clin Periodontol 37:1029–1038CrossRefPubMed Artzi Z, Nemcovsky CE, Tal H, Weinberg E, Weinreb M, Prasad H, Rohrer MD, Kozlovsky A (2010) Simultaneous versus two-stage implant placement and guided bone regeneration in the canine: histomorphometry at 8 and 16 months. J Clin Periodontol 37:1029–1038CrossRefPubMed
21.
go back to reference Chiapasco M, Zaniboni M (2009) Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: a systematic review. Clin Oral Implants Res 20:113–123CrossRefPubMed Chiapasco M, Zaniboni M (2009) Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: a systematic review. Clin Oral Implants Res 20:113–123CrossRefPubMed
22.
go back to reference Jung RE, Hälg GA, Thoma DS, Hämmerle CH (2009) A randomized, controlled clinical trial to evaluate a new membrane for guided bone regeneration around dental implants. Clin Oral Implants Res 20:162–168CrossRefPubMed Jung RE, Hälg GA, Thoma DS, Hämmerle CH (2009) A randomized, controlled clinical trial to evaluate a new membrane for guided bone regeneration around dental implants. Clin Oral Implants Res 20:162–168CrossRefPubMed
23.
go back to reference Le BT, Borzabadi-Farahani (2013) Simultaneous implant placement and bone grafting with particulate mineralized allograft in sites with buccal wall defects, a three-year follow-up and review of literature. J Craniomaxillofac. doi:10.1016/j.jcms.2013.07.026 Le BT, Borzabadi-Farahani (2013) Simultaneous implant placement and bone grafting with particulate mineralized allograft in sites with buccal wall defects, a three-year follow-up and review of literature. J Craniomaxillofac. doi:10.​1016/​j.​jcms.​2013.​07.​026
24.
go back to reference Masesh L, Kotsakis G, Venkataraman N, Shukla S, Prasad H (2013) Ridge preservation with the socket-plug technique utilizing an alloplastic putty bone substitute or a particulate xenograft: a histological pilot study. J Oral Implantol. doi:10.1563/AAID-JOI-D-13-00025 Masesh L, Kotsakis G, Venkataraman N, Shukla S, Prasad H (2013) Ridge preservation with the socket-plug technique utilizing an alloplastic putty bone substitute or a particulate xenograft: a histological pilot study. J Oral Implantol. doi:10.​1563/​AAID-JOI-D-13-00025
Metadata
Title
Clinical results of implant placement in resorbed ridges using simultaneous guided bone regeneration: a multicenter case series
Authors
Ioannis Konstantinidis
Tarun Kumar
Udatta Kher
Panagiotis D. Stanitsas
James E. Hinrichs
Georgios A. Kotsakis
Publication date
01-03-2015
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 2/2015
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-014-1268-4

Other articles of this Issue 2/2015

Clinical Oral Investigations 2/2015 Go to the issue