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Clinical Oral Investigations

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01-12-2012 | Original Article

Eosinophils may predict occult lymph node metastasis in early oral cancer

Authors: D. T. Oliveira, T. P. Biassi, S. E. S. Faustino, A. L. Carvalho, G. Landman, L. P. Kowalski

Published in: Clinical Oral Investigations | Issue 6/2012

Abstract

Objective

The aim of this study was to investigate whether tumor-associated tissue eosinophilia (TATE) in early oral squamous cell carcinoma (OSCC) would aid in predicting occult lymph node metastasis.

Patients and methods

Seventy-one patients undergoing elective neck dissection for T1 and T2 OSCC were evaluated for clinical features, prognosis, and TATE. The degree of TATE in OSCC was statistically analyzed in relation to the clinicopathological features, tumor invasion, occult lymph node metastasis, and survival using χ ² test and Kaplan–Meier method.

Results

Statistical analysis revealed that intense TATE was a significant feature (p = 0.004) to predict occult lymph node metastasis in patients with early OSCC. All regional recurrences of the OSCC occurred in patients showing intense TATE.

Conclusions

These results suggest that intense TATE can be clinically used as a predictive factor for occult lymph node metastasis.

Clinical relevance

The presence of intense TATE is an adjunctive histopathological marker to reinforce the indication of elective neck dissection of the patients with early OSCC.

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Title: Eosinophils may predict occult lymph node metastasis in early oral cancer
Authors: D. T. Oliveira
T. P. Biassi
S. E. S. Faustino
A. L. Carvalho
G. Landman
L. P. Kowalski
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 6/2012
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-011-0651-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Eosinophils may predict occult lymph node metastasis in early oral cancer

Abstract

Objective

Patients and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Patients and methods

Results

Conclusions

Clinical relevance

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