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01-08-2012 | Original Article

In situ remineralization of white-spot enamel lesions by 500 and 1,100 ppm F dentifrices

Authors: Poornima K. Mensinkai, Renzo A. Ccahuana-Vasquez, Irene Chedjieu, Bennett T. Amaechi, Allen C. Mackey, Trenton J. Walker, Douglas D. Blanken, Robert L. Karlinsey

Published in: Clinical Oral Investigations | Issue 4/2012

Abstract

The aim of this study was to evaluate the remineralization potential of three silica-containing NaF dentifrice systems in an intraoral model. Subjects (N = 30) in this randomized, three-phase, 28-day, crossover study served as their own control. Each participant wore a customized orthodontic appliance attached to a mandibular molar and contained one tooth block with caries-like lesion. For each phase, participants engaged in twice-daily brushing for 2 min with one of the following dentifrices: 500 ppm F, 500 ppm F plus functionalized β-tricalcium phosphate (fTCP), and a clinically proven 1,100 ppm F. After each phase, appliances were removed, and specimens were analyzed using surface microhardness (SMH), transverse microradiography (TMR), and cross-sectional microhardness (CSMH). Statistically significant (p < 0.05) remineralization of white-spot lesions relative to baseline occurred for each dentifrice as determined with SMH and TMR. No significant differences (p > 0.05) in SMH were found among the three groups, but trending revealed the 500 ppm F plus fTCP produced 26% and 27% greater SMH recovery relative to 500 and 1,100 ppm F, respectively. Similarly, no significant differences (p > 0.05) in TMR were found among the groups. However, the 500 ppm F plus fTCP dentifrice produced 10% and 38% greater mineral recovery relative to 500 and 1,100 ppm F, respectively, while reducing the lesion depth 30% and 52%, respectively. Significant differences (p < 0.05) in CSMH existed among the three dentifice groups at different enamel depths, but statistical differences (p < 0.05) in relative lesion size were only found between 500 ppm F plus fTCP and 500 ppm F. The combination of fTCP and fluoride in a single-compartment, water-based dentifrice can cooperate with fluoride to produce significant remineralization. These results suggest that the combination of 500 ppm F with fTCP may provide comparable anticaries benefits relative to a 1,100 ppm F dentifrice.

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Title: In situ remineralization of white-spot enamel lesions by 500 and 1,100 ppm F dentifrices
Authors: Poornima K. Mensinkai
Renzo A. Ccahuana-Vasquez
Irene Chedjieu
Bennett T. Amaechi
Allen C. Mackey
Trenton J. Walker
Douglas D. Blanken
Robert L. Karlinsey
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 4/2012
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-011-0591-2

At a glance: The STEP trials

Springer Medicine

In situ remineralization of white-spot enamel lesions by 500 and 1,100 ppm F dentifrices

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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