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Published in:

01-02-2012 | Original Article

C-reactive protein in relation to early atherosclerosis and periodontitis

Authors: Maha Yakob, Jukka H. Meurman, Tomas Jogestrand, Jacek Nowak, Per-Östen Söder, Birgitta Söder

Published in: Clinical Oral Investigations | Issue 1/2012

Abstract

Periodontitis may affect atherosclerosis via the chronic inflammation. We investigated high-sensitivity C-reactive protein (hsCRP) in relation to early vascular atherosclerotic changes in non-symptomatic subjects with and without long-term periodontitis. Carotid ultrasonography with calculation of common carotid artery intima-media area (cIMA) was performed, and hsCRP and atherosclerosis risk factors were analysed in randomly chosen 93 patients with periodontitis and 41 controls. The relationship between hsCRP, cIMA and atherosclerosis risk factors was evaluated with multiple logistic regression analysis. Women displayed lower hsCRP (p < 0.05) and higher serum HDL (p < 0.001) than men. In all patients with periodontitis, cIMA values were higher than in controls. Periodontitis appeared to be a major predictor for increased cIMA (odds ratio, 3.82; 95% confidence interval, 1.19–12.26). Neither of these factors was significantly associated with hsCRP which thus appeared not sensitive enough to be a marker for periodontitis or atherosclerosis. Hence, irrespective of low hsCRP levels, periodontitis appeared to increase the risk for atherosclerosis.

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Title: C-reactive protein in relation to early atherosclerosis and periodontitis
Authors: Maha Yakob
Jukka H. Meurman
Tomas Jogestrand
Jacek Nowak
Per-Östen Söder
Birgitta Söder
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 1/2012
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-010-0487-6

At a glance: The STEP trials

Springer Medicine

C-reactive protein in relation to early atherosclerosis and periodontitis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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