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Clinical Oral Investigations
Published in: Clinical Oral Investigations 3/2006

Open Access 01-09-2006 | Original Article

Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs

Authors: Jürgen Becker, Axel Kirsch, Frank Schwarz, Maria Chatzinikolaidou, Daniel Rothamel, Vojislav Lekovic, Herbert Peter Jennissen

Published in: Clinical Oral Investigations | Issue 3/2006

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Abstract

The aim of the present study was to investigate bone formation to recombinant human bone morphogenetic protein-2 (rhBMP-2)-biocoated and rhBMP-2-nonbiocoated titanium implants after implantation in dogs. Implantation of sand-blasted and acid-etched (C), chromosulfuric acid surface-enhanced (CSA), and rhBMP-2-biocoated CSA [BMP-A: noncovalently immobilized rhBMP-2 (596 ng/cm2), BMP-B: covalently immobilized rhBMP-2 (819 ng/cm2)] implants was performed in both the mandible and tibia of dogs. After 4 weeks of healing, the percentage of direct bone to implant contact (BIC) and the induced bone density (BD) at a distance of less than and greater than 1 mm adjacent to each implant was assessed. Histomorphometric analysis of implants inserted in the mandible and tibia revealed that BIC values appeared to be highest in the BMP-B group, followed by BMP-A, CSA, and C. BD as measured at a distance of <1 mm revealed obvious differences between groups: BMP-B>BMP-A>CSA>C. However, no differences between groups were observed at a distance of >1 mm. Within the limits of the present study, it may be concluded that rhBMP-2 immobilized by covalent and noncovalent methods on CSA-treated implant surfaces seemed to be stable and promoted direct bone apposition in a concentration-dependant manner.
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Metadata
Title
Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs
Authors
Jürgen Becker
Axel Kirsch
Frank Schwarz
Maria Chatzinikolaidou
Daniel Rothamel
Vojislav Lekovic
Herbert Peter Jennissen
Publication date
01-09-2006
Publisher
Springer-Verlag
Published in
Clinical Oral Investigations / Issue 3/2006
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-006-0049-0

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