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Open Access 28-02-2024 | Parkinson's Disease | Neurology and Preclinical Neurological Studies - Original Article

Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes

Authors: Radim Krupička, Christiane Malá, Slávka Neťuková, Tereza Hubená, Filip Havlík, Ondrej Bezdicek, Petr Dušek, Evžen Růžička

Published in: Journal of Neural Transmission

Abstract

In Parkinson’s disease (PD), impaired gait and cognition affect daily activities, particularly in the more advanced stages of the disease. This study investigated the relationship between gait parameters, cognitive performance, and brain morphology in patients with early untreated PD. 64 drug-naive PD patients and 47 healthy controls (HC) participated in the study. Single- and dual-task gait (counting task) were examined using an expanded Timed Up & Go Test measured on a GaitRite walkway. Measurements included gait speed, stride length, and cadence. A brain morphometry analysis was performed on T1-weighted magnetic resonance (MR) images. In PD patients compared to HC, gait analysis revealed reduced speed (p < 0.001) and stride length (p < 0.001) in single-task gait, as well as greater dual-task cost (DTC) for speed (p = 0.007), stride length (p = 0.014) and cadence (p = 0.029). Based on the DTC measures in HC, PD patients were further divided into two subgroups with normal DTC (PD-nDTC) and abnormally increased DTC (PD-iDTC). For PD-nDTC, voxel-based morphometric correlation analysis revealed a positive correlation between a cluster in the left primary motor cortex and stride-length DTC (r = 0.57, p = 0.027). For PD-iDTC, a negative correlation was found between a cluster in the right lingual gyrus and the DTC for gait cadence (r=-0.35, p_FWE = 0.018). No significant correlations were found in HC. The associations found between brain morphometry and gait performance with a concurrent cognitive task may represent the substrate for gait and cognitive impairment occurring since the early stages of PD.

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Title: Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes
Authors: Radim Krupička
Christiane Malá
Slávka Neťuková
Tereza Hubená
Filip Havlík
Ondrej Bezdicek
Petr Dušek
Evžen Růžička
Publication date: 28-02-2024
Publisher: Springer Vienna
Keyword: Parkinson's Disease
Published in: Journal of Neural Transmission
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-024-02758-2

At a glance: The STEP trials

Springer Medicine

Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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