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01-05-2020 | Repetitive Transcranial Magnetic Stimulation | Neurology and Preclinical Neurological Studies - Review Article

Non-pharmacological management of cognitive impairment in Parkinson’s disease

Authors: Monika Pupíková, Irena Rektorová

Published in: Journal of Neural Transmission | Issue 5/2020

Abstract

We evaluated the therapeutic effects of non-pharmacological interventions (cognitive training, physical activity, and non-invasive brain stimulation) on cognitive symptoms in Parkinson’s disease. A comprehensive literature search for non-pharmacological intervention randomized controlled trials was performed and effect sizes were calculated for each suitable study intervention approach and cognitive domain. Despite the heterogeneity of the study results, we report level B evidence for the probable efficacy of cognitive training in improving or maintaining attention/working memory and memory domains. Level C (possible efficacy) evidence was found for specific physical training types with respect to enhancing executive functions. Non-invasive brain stimulation techniques and combinatorial approaches show preliminary but promising results. Prediction markers evaluating distinct treatment responses should be identified that would help to choose the best candidates for specific treatment strategies and cognitive symptoms. Future directions and recommendations are discussed.

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Title: Non-pharmacological management of cognitive impairment in Parkinson’s disease
Authors: Monika Pupíková
Irena Rektorová
Publication date: 01-05-2020
Publisher: Springer Vienna
Keywords: Repetitive Transcranial Magnetic Stimulation
Physical Therapy
Parkinson's Disease
Published in: Journal of Neural Transmission / Issue 5/2020
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-019-02113-w

At a glance: The STEP trials

Springer Medicine

Non-pharmacological management of cognitive impairment in Parkinson’s disease

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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