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01-05-2019 | Tremor | Neurology and Preclinical Neurological Studies - Original Article

Abnormal hippocampal subfields are associated with cognitive impairment in Essential Tremor

Authors: Shweta Prasad, Apurva Shah, Ketaki Swapnil Bhalsing, Keshav J. Kumar, Jitender Saini, Madhura Ingalhalikar, Pramod Kumar Pal

Published in: Journal of Neural Transmission | Issue 5/2019

Abstract

Multi-domain cognitive impairment (CI) has been frequently described in patients with essential tremor (ET). However, the exact neuroanatomical basis for this impairment is uncertain. This study aims to ascertain the role of the hippocampal formation in cognitive impairment in ET. Forty patients with ET and 40 age, gender and education matched healthy controls (HC) were enrolled. Cognition was assessed using a structured neuropsychological battery and patients were categorized as ET with CI (ETCI) and ET without CI (ETNCI). Automatic segmentation of hippocampal subfields was performed using FreeSurfer 6.0. The obtained volumes were correlated with scores of neuropsychological tests. Significant atrophy of the left subiculum, CA4, granule-cell layer of dentate gyrus, right molecular layer, and hypertrophy of bilateral parasubiculum, right hippocampus-amygdala-transition-area, bilateral hippocampal tail (HT) and widening of right hippocampal fissure was observed in ET. Trends toward atrophy of right subiculum, and widening of left HF was also observed. Comparison of HC and ETCI revealed atrophy of right subiculum, hypertrophy of bilateral parasubiculum, HT, and widening of left HF. ETCI showed a trend toward widening of right HF. ETNCI had isolated left parasubicular hypertrophy and in comparison, to ETNCI the ETCI subgroup had atrophy of bilateral fimbria. Significant correlations were observed between the volumes of HT, HF, fimbria and scores of tests for executive function, working and verbal memory. Patients with ET have significant volumetric abnormalities of several hippocampal subfields and these abnormalities may be important contributors for some forms of cognitive impairment observed in ET.

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Title: Abnormal hippocampal subfields are associated with cognitive impairment in Essential Tremor
Authors: Shweta Prasad
Apurva Shah
Ketaki Swapnil Bhalsing
Keshav J. Kumar
Jitender Saini
Madhura Ingalhalikar
Pramod Kumar Pal
Publication date: 01-05-2019
Publisher: Springer Vienna
Keyword: Tremor
Published in: Journal of Neural Transmission / Issue 5/2019
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-019-01992-3

ACC 2024 Congress

Springer Medicine

Abnormal hippocampal subfields are associated with cognitive impairment in Essential Tremor

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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