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Published in: Journal of Neural Transmission 12/2018

01-12-2018 | Neurology and Preclinical Neurological Studies - Review Article

Correlation between MCP-1-2518A/G polymorphism and the risk of Alzheimer’s disease

Authors: Yan Wang, Siyi Huang, Xiaoling Wu, Yong Wang, Deqi Jiang

Published in: Journal of Neural Transmission | Issue 12/2018

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Abstract

The -2518A/G polymorphism in monocyte chemotactic protein-1 (MCP-1) has been extensively investigated for association with Alzheimer’s disease (AD); however, the results from different studies are inconsistent. The aim of this study was to draw an accurate conclusion of the association. All eligible case–control studies were searched in PubMed, Embase, Chinese National Knowledge Infrastructure, China Biological Medicine Databases, and Wanfang Databases. Eight case–control studies with a total of 2370 cases and 2413 controls were eligible to be included in this meta-analysis. The association was evaluated by calculating the odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Overall, there was no significant association between MCP-1-2518A/G polymorphism and AD risk in all genetic models (the allele model G vs. A: OR = 1.15, 95% CI 0.92–1.45, p = 0.22; the co-dominant model GG vs. AA: OR = 1.38, 95% CI 0.80–2.36, p = 0.25; the dominant model AG + GG vs. AA: OR = 1.14, 95% CI 0.89–1.46, p = 0.31; the recessive model GG vs. AG + AA: OR = 1.35, 95% CI 0.87–2.09, p = 0.18). In subgroup analysis by ethnicity, a significant difference was not detected in both Caucasians and Asians. In allele model (G vs. A), the required sample size of 31858 was calculated by applying trial sequential analysis. Cumulative z curve is always below the trial sequential monitoring boundary and is nominally statistically significant (Z = 1.96). A consistent result was obtained in other genetic models. In summary, the present meta-analysis suggests that MCP-1-2518A/G polymorphism may not be associated with genetic susceptibility of AD in general population, but the association remains indeterminate due to the insufficient evidence.
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Literature
go back to reference Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM et al (2000) Inflammation and Alzheimer’s disease. Neurobiol Aging 21(3):383–421CrossRef Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM et al (2000) Inflammation and Alzheimer’s disease. Neurobiol Aging 21(3):383–421CrossRef
go back to reference Banisadr G, Gosselin RD, Mechighel P, Rostene W, Kitabgi P, Melik PS (2005) Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. J Comp Neurol 492(2):178–192CrossRef Banisadr G, Gosselin RD, Mechighel P, Rostene W, Kitabgi P, Melik PS (2005) Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. J Comp Neurol 492(2):178–192CrossRef
go back to reference Britschgi M, Wyss-Coray T (2007) Systemic and acquired immune responses in Alzheimer’s disease. Int Rev Neurobiol 82:205–233CrossRef Britschgi M, Wyss-Coray T (2007) Systemic and acquired immune responses in Alzheimer’s disease. Int Rev Neurobiol 82:205–233CrossRef
go back to reference Combarros O, Infante J, Llorca J, Berciano J (2004) No evidence for association of the monocyte chemoattractant protein-1 (-2518) gene polymorphism and Alzheimer’s disease. Neurosci Lett 360(1–2):25–28CrossRef Combarros O, Infante J, Llorca J, Berciano J (2004) No evidence for association of the monocyte chemoattractant protein-1 (-2518) gene polymorphism and Alzheimer’s disease. Neurosci Lett 360(1–2):25–28CrossRef
go back to reference Conductier G, Blondeau N, Guyon A, Nahon JL, Rovere C (2010) The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. J Neuroimmunol 224(1–2):93–100CrossRef Conductier G, Blondeau N, Guyon A, Nahon JL, Rovere C (2010) The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. J Neuroimmunol 224(1–2):93–100CrossRef
go back to reference Deshmane SL, Kremlev S, Amini S, Sawaya BE (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res 29(6):313–326CrossRef Deshmane SL, Kremlev S, Amini S, Sawaya BE (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res 29(6):313–326CrossRef
go back to reference Di Bona D, Plaia A, Vasto S, Cavallone L, Lescai F, Franceschi C et al (2008) Association between the interleukin-1beta polymorphisms and Alzheimer’s disease: a systematic review and meta-analysis. Brain Res Rev 59(1):155–163CrossRef Di Bona D, Plaia A, Vasto S, Cavallone L, Lescai F, Franceschi C et al (2008) Association between the interleukin-1beta polymorphisms and Alzheimer’s disease: a systematic review and meta-analysis. Brain Res Rev 59(1):155–163CrossRef
go back to reference Di Bona D, Candore G, Franceschi C, Licastro F, Colonna-Romano G, Camma C et al (2009) Systematic review by meta-analyses on the possible role of TNF-alpha polymorphisms in association with Alzheimer’s disease. Brain Res Rev 61(2):60–68CrossRef Di Bona D, Candore G, Franceschi C, Licastro F, Colonna-Romano G, Camma C et al (2009) Systematic review by meta-analyses on the possible role of TNF-alpha polymorphisms in association with Alzheimer’s disease. Brain Res Rev 61(2):60–68CrossRef
go back to reference Fenoglio C, Galimberti D, Lovati C, Guidi I, Gatti A, Fogliarino S et al (2004) MCP-1 in Alzheimer’s disease patients: A-2518G polymorphism and serum levels. Neurobiol Aging 25(9):1169–1173CrossRef Fenoglio C, Galimberti D, Lovati C, Guidi I, Gatti A, Fogliarino S et al (2004) MCP-1 in Alzheimer’s disease patients: A-2518G polymorphism and serum levels. Neurobiol Aging 25(9):1169–1173CrossRef
go back to reference Flex A, Giovannini S, Biscetti F, Liperoti R, Spalletta G, Straface G et al (2014) Effect of proinflammatory gene polymorphisms on the risk of Alzheimer’s disease. Neurodegener Dis 13(4):230–236PubMed Flex A, Giovannini S, Biscetti F, Liperoti R, Spalletta G, Straface G et al (2014) Effect of proinflammatory gene polymorphisms on the risk of Alzheimer’s disease. Neurodegener Dis 13(4):230–236PubMed
go back to reference Galimberti D, Fenoglio C, Lovati C, Venturelli E, Guidi I, Corra B et al (2006) Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease. Neurobiol Aging 27(12):1763–1768CrossRef Galimberti D, Fenoglio C, Lovati C, Venturelli E, Guidi I, Corra B et al (2006) Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease. Neurobiol Aging 27(12):1763–1768CrossRef
go back to reference Hanisch UK (2002) Microglia as a source and target of cytokines. Glia 40(2):140–155CrossRef Hanisch UK (2002) Microglia as a source and target of cytokines. Glia 40(2):140–155CrossRef
go back to reference Huerta C, Alvarez V, Mata IF, Coto E, Ribacoba R, Martinez C et al (2004) Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer’s and Parkinson’s disease. Neurosci Lett 370(2–3):151–154CrossRef Huerta C, Alvarez V, Mata IF, Coto E, Ribacoba R, Martinez C et al (2004) Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer’s and Parkinson’s disease. Neurosci Lett 370(2–3):151–154CrossRef
go back to reference Jibiki T, Terai M, Shima M, Ogawa A, Hamada H, Kanazawa M et al (2001) Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease. Arthritis Rheum 44(9):2211–2212CrossRef Jibiki T, Terai M, Shima M, Ogawa A, Hamada H, Kanazawa M et al (2001) Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease. Arthritis Rheum 44(9):2211–2212CrossRef
go back to reference Lee WJ, Liao YC, Wang YF, Lin IF, Wang SJ, Fuh JL (2018) Plasma MCP-1 and cognitive decline in patients with Alzheimer’s disease and mild cognitive impairment: a two-year follow-up study. Sci Rep 8(1):1280CrossRef Lee WJ, Liao YC, Wang YF, Lin IF, Wang SJ, Fuh JL (2018) Plasma MCP-1 and cognitive decline in patients with Alzheimer’s disease and mild cognitive impairment: a two-year follow-up study. Sci Rep 8(1):1280CrossRef
go back to reference Luster AD (1998) Chemokines–chemotactic cytokines that mediate inflammation. N Engl J Med 338(7):436–445CrossRef Luster AD (1998) Chemokines–chemotactic cytokines that mediate inflammation. N Engl J Med 338(7):436–445CrossRef
go back to reference Nishimura M, Kuno S, Mizuta I, Ohta M, Maruyama H, Kaji R et al (2003) Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson’s disease. Mov Disord 18(8):953–955CrossRef Nishimura M, Kuno S, Mizuta I, Ohta M, Maruyama H, Kaji R et al (2003) Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson’s disease. Mov Disord 18(8):953–955CrossRef
go back to reference Pola R, Flex A, Gaetani E, Proia AS, Papaleo P, Di Giorgio A et al (2004) Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer’s disease in Italians. Exp Gerontol 39(8):1249–1252CrossRef Pola R, Flex A, Gaetani E, Proia AS, Papaleo P, Di Giorgio A et al (2004) Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer’s disease in Italians. Exp Gerontol 39(8):1249–1252CrossRef
go back to reference Porcellini E, Ianni M, Carbone I, Franceschi M, Licastro F (2013) Monocyte chemoattractant protein-1 promoter polymorphism and plasma levels in alzheimer’s disease. Immun Ageing 10(1):6CrossRef Porcellini E, Ianni M, Carbone I, Franceschi M, Licastro F (2013) Monocyte chemoattractant protein-1 promoter polymorphism and plasma levels in alzheimer’s disease. Immun Ageing 10(1):6CrossRef
go back to reference Rovin BH, Lu L, Saxena R (1999) A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Commun 259(2):344–348CrossRef Rovin BH, Lu L, Saxena R (1999) A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Commun 259(2):344–348CrossRef
go back to reference Sozzani S, Zhou D, Locati M, Rieppi M, Proost P, Magazin M et al (1994) Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. J Immunol 152(7):3615–3622PubMed Sozzani S, Zhou D, Locati M, Rieppi M, Proost P, Magazin M et al (1994) Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. J Immunol 152(7):3615–3622PubMed
go back to reference Wang M, Jia J (2010) The interleukin-6 gene—572C/G promoter polymorphism modifies Alzheimer’s risk in APOE epsilon 4 carriers. Neurosci Lett 482(3):260–263CrossRef Wang M, Jia J (2010) The interleukin-6 gene—572C/G promoter polymorphism modifies Alzheimer’s risk in APOE epsilon 4 carriers. Neurosci Lett 482(3):260–263CrossRef
go back to reference Wenk GL (2003) Neuropathologic changes in Alzheimer’s disease. J Clin Psychiatry 64(Suppl 9):7–10PubMed Wenk GL (2003) Neuropathologic changes in Alzheimer’s disease. J Clin Psychiatry 64(Suppl 9):7–10PubMed
go back to reference Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease—a double-edged sword. Neuron 35(3):419–432CrossRef Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease—a double-edged sword. Neuron 35(3):419–432CrossRef
Metadata
Title
Correlation between MCP-1-2518A/G polymorphism and the risk of Alzheimer’s disease
Authors
Yan Wang
Siyi Huang
Xiaoling Wu
Yong Wang
Deqi Jiang
Publication date
01-12-2018
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 12/2018
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-018-1936-7

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