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Journal of Neural Transmission
Published in: Journal of Neural Transmission 5/2018

01-05-2018 | Neurology and Preclinical Neurological Studies - Review Article

The IL-1β phenomena in neuroinflammatory diseases

Authors: Andrew S. Mendiola, Astrid E. Cardona

Published in: Journal of Neural Transmission | Issue 5/2018

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Abstract

It is becoming increasingly clear that neuroinflammation has a causal role in the pathogenesis of central nervous system (CNS)-related diseases, and therefore therapeutic strategies targeting the regulation or availability of inflammatory mediators can be used to prevent or mitigate pathology. Interestingly, the proinflammatory cytokine, interleukin-1 beta (IL-1β), has been implicated in perpetuating immune responses and contributing to disease severity in a variety of CNS diseases ranging from multiple sclerosis, neurodegenerative diseases, traumatic brain injury, and diabetic retinopathy. Moreover, pharmacological blockade of IL-1 signaling has shown to be beneficial in some autoimmune and autoinflammatory diseases, making IL-1β a promising therapeutic target in neuroinflammatory conditions. This review highlights recent advances of our understanding on the multifaceted roles of IL-1β in neuroinflammatory diseases.
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Metadata
Title
The IL-1β phenomena in neuroinflammatory diseases
Authors
Andrew S. Mendiola
Astrid E. Cardona
Publication date
01-05-2018
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 5/2018
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-017-1732-9

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