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Open Access 01-05-2017 | Translational Neurosciences - Short communication

Psychomotor effect differences between l-methamphetamine and d-methamphetamine are independent of murine plasma and brain pharmacokinetics profiles

Authors: Tetsuya Nishimura, Kazue Takahata, Yuri Kosugi, Takaaki Tanabe, Shizuko Muraoka

Published in: Journal of Neural Transmission | Issue 5/2017

Abstract

l-Methamphetamine has been occasionally referred to as a stimulant similar to d-methamphetamine, probably owing to insufficient comparative studies. Here, we directly compared psychomotor efficacies and pharmacokinetics of methamphetamine enantiomers in mice. Only d-methamphetamine, but not l-methamphetamine, induced stereotypy and sensitization at 1–10 mg/kg. However, plasma pharmacokinetic parameters of 10 mg/kg l-methamphetamine were ≥tenfold those of 1 mg/kg d-methamphetamine. These results clearly indicate that differential psychomotor efficacies of methamphetamine enantiomers are independent of their pharmacokinetic profiles.

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Title: Psychomotor effect differences between l-methamphetamine and d-methamphetamine are independent of murine plasma and brain pharmacokinetics profiles
Authors: Tetsuya Nishimura
Kazue Takahata
Yuri Kosugi
Takaaki Tanabe
Shizuko Muraoka
Publication date: 01-05-2017
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 5/2017
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-017-1694-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Psychomotor effect differences between l-methamphetamine and d-methamphetamine are independent of murine plasma and brain pharmacokinetics profiles

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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