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Journal of Neural Transmission
Published in: Journal of Neural Transmission 4/2017

01-04-2017 | High Impact Review in Neuroscience, Neurology or Psychiatry - Review Article

Deep brain stimulation for dystonia: a novel perspective on the value of genetic testing

Authors: H. A. Jinnah, Ron Alterman, Christine Klein, Joachim K. Krauss, Elena Moro, Marie Vidailhet, Robert Raike

Published in: Journal of Neural Transmission | Issue 4/2017

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Abstract

The dystonias are a group of disorders characterized by excessive muscle contractions leading to abnormal movements and postures. There are many different clinical manifestations and underlying causes. Deep brain stimulation (DBS) provides an effect treatment, but outcomes can vary considerably among the different subtypes of dystonia. Several variables are thought to contribute to this variation including age of onset and duration of dystonia, specific characteristics of the dystonic movements, location of stimulation and stimulator settings, and others. The potential contributions of genetic factors have received little attention. In this review, we summarize evidence that some of the variation in DBS outcomes for dystonia is due to genetic factors. The evidence suggests that more methodical genetic testing may provide useful information in the assessment of potential surgical candidates, and in advancing our understanding of the biological mechanisms that influence DBS outcomes.
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Metadata
Title
Deep brain stimulation for dystonia: a novel perspective on the value of genetic testing
Authors
H. A. Jinnah
Ron Alterman
Christine Klein
Joachim K. Krauss
Elena Moro
Marie Vidailhet
Robert Raike
Publication date
01-04-2017
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 4/2017
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-016-1656-9

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The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection

Neurology and Preclinical Neurological Studies - Original Article

Age-dependent alpha-synuclein accumulation is correlated with elevation of mitochondrial TRPC3 in the brains of monkeys and mice

Neurology and Preclinical Neurological Studies - Original Article

Comparative analysis of speech impairment and upper limb motor dysfunction in Parkinson’s disease