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01-12-2016 | Psychiatry and Preclinical Psychiatric Studies - Original Article

Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome

Authors: Yael Midbari Kufert, Ariela Nachmani, Einat Nativ, Abraham Weizman, Doron Gothelf

Published in: Journal of Neural Transmission | Issue 12/2016

Abstract

In this study, we report the developmental, physical and psychiatric manifestations of 22q11.2 deletion syndrome (22q11.2DS) in a large Israeli cohort, and search for a possible association between preterm birth and the risk for psychotic disorders. The study population consisted of 128 individuals with 22q11.2DS (77 male, 51 female), aged 1–55 years (mean ± SD 12.9 ± 11.0). All subjects underwent a comprehensive medical evaluation. All subjects older than 5 years (n = 104) were also evaluated psychiatrically. Overall, we found rates of physical manifestations similar to those previously reported in the literature. Psychiatric disorders were very common among our study population, with psychotic disorders occurring in 16.3 % of the psychiatrically evaluated population. We found an association between the presence of psychotic disorders and preterm birth. Our results replicate and extend the findings of a previous work and suggest that the evolution of psychosis in 22q11.2DS is a neurodevelopmental process with early obstetric and medical precursors.

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Title: Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome
Authors: Yael Midbari Kufert
Ariela Nachmani
Einat Nativ
Abraham Weizman
Doron Gothelf
Publication date: 01-12-2016
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 12/2016
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-016-1607-5

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Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome

Abstract

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Springer Medicine

Abstract

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