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01-08-2014 | Neurology and Preclinical Neurological Studies - Review Article

The role of glutamate and its receptors in multiple sclerosis

Authors: Ivana R. Stojanovic, Milos Kostic, Srdjan Ljubisavljevic

Published in: Journal of Neural Transmission | Issue 8/2014

Abstract

Glutamate is an excitatory neurotransmitter of the central nervous system, which has a central role in a complex communication network established between neurons, astrocytes, oligodendrocytes, and microglia. Multiple abnormal triggers such as energy deficiency, oxidative stress, mitochondrial dysfunction, and calcium overload can lead to abnormalities in glutamate signaling. Thus, the disturbance of glutamate homeostasis could affect practically all physiological functions and interactions of brain cells, leading to excitotoxicity. Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by glutamate. Although neuron degeneration and death are the ultimate consequences of multiple sclerosis (MS), it is now widely accepted that alterations in the function of surrounding glial cells are key features in the progression of the disease. The present knowledge raise the possibility that the modulation of glutamate release and transport, as well as receptors blockade or glutamate metabolism modulation, might be relevant targets for the development of future therapeutic interventions in MS.

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Title: The role of glutamate and its receptors in multiple sclerosis
Authors: Ivana R. Stojanovic
Milos Kostic
Srdjan Ljubisavljevic
Publication date: 01-08-2014
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 8/2014
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-014-1188-0

At a glance: The STEP trials

Springer Medicine

The role of glutamate and its receptors in multiple sclerosis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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